Výsledky vyhledávání - "Néstor Prieto-Domínguez"

FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

Autor: Chloe Shay, Reid Loveless, Néstor Prieto-Domínguez, Liwei Lang, Yong Teng, Yuanping Xiong, Caleb Jensen

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)

Background There is no consensus about the effective dosages of melatonin in cancer management, thus, it is imperative to fully understand the dose-dependent responsiveness of cancer cells to melatonin and the underlying mechanisms. Methods Head and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26914ebb49618fa7191a15204249f07c
https://pubmed.ncbi.nlm.nih.gov/33691750

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La biotecnología en la salud humana: el hito de los anticuerpos monoclonales

Autor: Javier González Gallego, Néstor Prieto-Domínguez, José L. Mauriz, Raquel Ordóñez

Publikováno v: Ambiociencias. :12-33

La biotecnología está constituyéndose como una disciplina transversal con interés en diversas áreas como la salud humana y animal, el medioambiente, la agroalimentación, la industria o incluso los recursos marinos. La denominada biotecnología

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdb17131ae0bb118d17a7efd86b99a35
https://doi.org/10.18002/ambioc.v0i12.4944

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Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease

Autor: María Victoria García-Mediavilla, José L. Mauriz, Sonia Sánchez-Campos, Néstor Prieto-Domínguez, Javier González-Gallego

Publikováno v: Current Medicinal Chemistry. 25:814-838

Background Autophagy is a cellular pathway with the ability to maintain cell homeostasis through the elimination of damaged or useless cellular components, and its deregulation may initiate or aggravate different human diseases. Flavonoids, a group o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a45086818671a248ea3fbd0a44758d
https://doi.org/10.2174/0929867324666170918125155

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Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy

Autor: Flavia Fondevila, José L. Mauriz, Sara Carbajo-Pescador, Carolina Méndez-Blanco, Néstor Prieto-Domínguez, Javier González-Gallego, Andrés García-Palomo

Publikováno v: Oncotarget

// Nestor Prieto-Dominguez 1, 2, * , Carolina Mendez-Blanco 1, 2, * , Sara Carbajo-Pescador 1, 2 , Flavia Fondevila 1, 2 , Andres Garcia-Palomo 1, 3 , Javier Gonzalez-Gallego 1, 2, ** and Jose L. Mauriz 1, 2, ** 1 Institute of Biomedicine (IBIOMED),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6c9f12a34dd1a4f288ee6e84935bc2
https://doi.org/10.18632/oncotarget.20592

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Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges

Autor: Yong Teng, Christopher Parnell, Néstor Prieto-Domínguez

Publikováno v: Cells, Vol 8, Iss 3, p 255 (2019)
Cells

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP. Small GTPases regulate key cellular processes (e.g., cell differentiation, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49dce60a591d7d839cce5f3188c4f513
http://www.mdpi.com/2073-4409/8/3/255

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Modulation of selective and non-selective autophagy by melatonin in conditions of normoxia and hypoxia: potential interest in the treatment of hepatocarcinoma with sorafenib Autores: Néstor Prieto-Domínguez = Modulación de la autofagia selectiva y no selectiva por melatonina en condiciones de normoxia e hipoxia: potencial interés en el tratamiento del hepatocarcinoma con sorafenib

Autor: Néstor Prieto-Domínguez

308 p. El HCC (cáncer hepatocelular) es la quinta enfermedad maligna más prevalente globalmente, así como la segunda causa de muerte relacionada con el cáncer más frecuente en hombres. El pronóstico de esta enfermedad es muy pobre debido a la d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ec0e1293a171b89260a7489e87b6f3
http://hdl.handle.net/10612/9817

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Inhibition of matrix metalloproteinase-9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in HepG2 liver cancer cells

Autor: Néstor Prieto-Domínguez, Javier González-Gallego, Sara Carbajo-Pescador, Andrés García-Palomo, Raquel Ordóñez, José L. Mauriz

Publikováno v: Journal of Pineal Research. 56:20-30

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide because of its high incidence and its metastatic potential. Extracellular matrix degradation by matrix metalloproteinases (MMPs) has been connected with cancer cell inva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d20731881b6e71616acf473cfe900
https://doi.org/10.1111/jpi.12092

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Modulation of Autophagy by Sorafenib: Effects on Treatment Response

Autor: Raquel Ordóñez, Jordi Muntané, José L. Mauriz, Javier González-Gallego, Néstor Prieto-Domínguez, Andrés García-Palomo, Anna Fernández

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Frontiers in Pharmacology

The multikinase inhibitor sorafenib is, at present, the only drug approved for the treatment of hepatocellular carcinoma (HCC), one of the most lethal types of cancer worldwide. However, the increase in the number of sorafenib tumor resistant cells r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86245e98bf930b10eecd0f3bfd18da3
http://hdl.handle.net/10261/180655

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