Výsledky vyhledávání - "Néstor M. Carballeira"

Akademický článek

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

Autor: Rosa M. Reguera, Christopher F. Prada, Raquel Alvarez-Velilla, Nashbly Montano, Néstor M. Carballeira, Rafael Balaña-Fouce

Publikováno v: Marine Drugs, Vol 11, Iss 10, Pp 3661-3675 (2013)

Sponges biosynthesize α-methoxylated fatty acids with unusual biophysical and biological properties and in some cases they display enhanced anticancer activities. However, the antiprotozoal properties of the α-methoxylated fatty acids have been les

Externí odkaz: https://doaj.org/article/89e8fe68cd524f64a75a256f575b00d7

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Akademický článek

Synthetic Fatty Acids Prevent Plasmid-Mediated Horizontal Gene Transfer

Autor: María Getino, David J. Sanabria-Ríos, Raúl Fernández-López, Javier Campos-Gómez, José M. Sánchez-López, Antonio Fernández, Néstor M. Carballeira, Fernando de la Cruz

Publikováno v: mBio, Vol 6, Iss 5 (2015)

ABSTRACT Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination of antibiotic resistance genes among human pathogens. Antibiotic resistance spread could be halted or diminished by molecules that interfere w

Externí odkaz: https://doaj.org/article/b9ca3b153caf48bea5b2697388ee788d

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Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug‐Resistant Staphylococcus aureus

Autor: Néstor M. Carballeira, David J. Sanabria-Ríos, Ashley Rivera‐Román, Joseph Mooney, Tomás Pereles‐De‐León, Solymar Medina, Damarith Díaz, Christian Morales-Guzman, Carlimar Ocasio-Malavé, Nataliya E. Chorna

Publikováno v: Lipids

In the present study, the structural characteristics that impart antibacterial activity to C16 alkynoic fatty acids (aFA) were further investigated. The syntheses of hexadecynoic acids (HDA) containing triple bonds at C-3, C-6, C-8, C-9, C-10, and C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8e9060ce76dacdb2296771d99e81e9
https://doi.org/10.1002/lipd.12213

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Synthesis of a novel brominated vinylic fatty acid with antileishmanial activity that effectively inhibits the Leishmania topoisomerase IB enzyme mediated by halogen bond formation

Autor: Victorio Jauregui Matos, Adriano D. Andricopulo, Néstor M. Carballeira, Rafael Balaña-Fouce, Leonardo L. G. Ferreira, Leilani M. Lotti Diaz, Denisse Alequín, Rosa M. Reguera, Yolanda Pérez-Pertejo, Mikhail Y. Golovko

Publikováno v: Pure and Applied Chemistry. 91:1405-1416

Many marine derived fatty acids, mainly from sponges, possess vinylic halogenated moieties (bromine or iodine) but their assessment as antileishmanial candidates remains elusive. In this work, we undertook the first total synthesis of a novel series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6f5a55eeb146bec507bcbdd82d57883
https://doi.org/10.1515/pac-2018-1113

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Antibacterial fatty acids: An update of possible mechanisms of action and implications in the development of the next-generation of antibacterial agents

Autor: David J. Sanabria-Ríos, Giancarlo Casillas-Vargas, Carlimar Ocasio-Malavé, Christian Morales-Guzman, Néstor M. Carballeira, Solymar Medina, René García Del Valle

Publikováno v: Progress in lipid research

The antibacterial activity of fatty acids (FA) is well known in the literature and represents a promising option for developing the next-generation of antibacterial agents to treat a broad spectrum of bacterial infections. FA are highly involved in l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9c1ba84b8c1bede8f1f371f0f972ea
https://pubmed.ncbi.nlm.nih.gov/33577909

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