Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.

Autor: Zheng T; School of Biological Sciences, Monash University, Clayton, Victoria, Australia.; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Juzenas S; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.; Institute of Biotechnology, Life Science Centre, Vilnius University, Vilnius, Lithuania., Cossais F; Institute of Anatomy, Christian-Albrechts-University of Kiel, Kiel, Germany., Burmeister G; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., Mayr G; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Jørgensen IF; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Teder-Laving M; Institute of Genomics, University of Tartu, Tartu, Estonia., Skogholt AH; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Chen S; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Strege PR; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Ito G; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.; Institute of Advanced Research, Tokyo Medical and Dental University, Tokyo, Japan., Banasik K; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Becker T; Department of General-, Visceral- Transplant-, Thoracic and Pediatric Surgery, Kiel University, Kiel, Germany., Bokelmann F; Medical Office for Surgery Preetz, Preetz, Germany., Brunak S; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Buch S; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany., Clausnitzer H; University Hospital Schleswig-Holstein, Institute of Clinical Chemistry, Thrombosis & Hemostasis Treatment Center, Campus Kiel & Lübeck, Kiel, Germany., Datz C; Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private Medical University of Salzburg, Oberndorf, Austria., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Doniec M; Medical office for Colo-Proctology Kiel, Kiel, Germany., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Forster M; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Frey N; Department of Internal Medicine III, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.; Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Kiel, Germany., Fritsche LG; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Gabrielsen ME; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Gräßle T; Epidemiology of highly pathogenic microorganisms, Robert Koch-Institute, Berlin, Germany.; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Gsur A; Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria., Gross J; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., Hampe J; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, Dresden, Germany., Hendricks A; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., Hinz S; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Jongen J; Department of Proctological Surgery Park Klinik Kiel, Kiel, Germany.; Proctological Office Kiel, Kiel, Germany., Junker R; University Hospital Schleswig-Holstein, Institute of Clinical Chemistry, Thrombosis & Hemostasis Treatment Center, Campus Kiel & Lübeck, Kiel, Germany., Karlsen TH; Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway., Hemmrich-Stanisak G; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Kruis W; Faculty of Medicine, University of Cologne, Cologne, Germany., Kupcinskas J; Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania., Laubert T; Department of Proctological Surgery Park Klinik Kiel, Kiel, Germany.; Proctological Office Kiel, Kiel, Germany.; University of Lübeck, Lübeck, Germany., Rosenstiel PC; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.; University Hospital of Schleswig-Holstein (UKSH), Kiel Campus, Kiel, Germany., Röcken C; Department of Pathology, University Medical Center Schleswig-Holstein, Kiel, Germany., Laudes M; Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine 1, University of Kiel, Kiel, Germany., Leendertz FH; Epidemiology of highly pathogenic microorganisms, Robert Koch-Institute, Berlin, Germany.; Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Lieb W; Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany., Limperger V; University Hospital Schleswig-Holstein, Institute of Clinical Chemistry, Thrombosis & Hemostasis Treatment Center, Campus Kiel & Lübeck, Kiel, Germany., Margetis N; University of Athens, Athens Euroclinic, Athens, Greece., Mätz-Rensing K; Pathology Unit, German Primate Center, Leibniz Institute for Primatology, Göttingen, Germany., Németh CG; Department of General-, Visceral- Transplant-, Thoracic and Pediatric Surgery, Kiel University, Kiel, Germany.; Department of Ophthalmology, Hospital Frankfurt Hoechst, Frankfurt, Germany., Ness-Jensen E; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway., Nowak-Göttl U; University Hospital Schleswig-Holstein, Institute of Clinical Chemistry, Thrombosis & Hemostasis Treatment Center, Campus Kiel & Lübeck, Kiel, Germany., Pandit A; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Pedersen OB; Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark., Peleikis HG; Department of Proctological Surgery Park Klinik Kiel, Kiel, Germany.; Proctological Office Kiel, Kiel, Germany., Peuker K; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, Dresden, Germany., Rodriguez CL; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rühlemann MC; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Schniewind B; General Hospital Lüneburg, Lüneburg, Germany., Schulzky M; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Skieceviciene J; Department of Gastroenterology, Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania., Tepel J; Department of General and Thoracic Surgery, Hospital Osnabrück, Osnabrück, Germany., Thomas L; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Laboratory Medicine, St.Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Uellendahl-Werth F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Ullum H; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Vogel I; Department of Surgery, Community Hospital Kiel, Kiel, Germany., Volzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., von Fersen L; Department Research & Conservation, Zoo Nuremberg, Nuremberg, Germany., von Schönfels W; Department of General-, Visceral- Transplant-, Thoracic and Pediatric Surgery, Kiel University, Kiel, Germany., Vanderwerff B; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Wilking J; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., Wittig M; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Zeissig S; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, Dresden, Germany., Zobel M; Department of Gastroenterology, Helios Hospital Weißeritztal, Freital, Germany., Zawistowski M; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Vacic V; 23andMe Inc, Sunnyvale, CA, USA., Sazonova O; 23andMe Inc, Sunnyvale, CA, USA., Noblin ES; 23andMe Inc, Sunnyvale, CA, USA., Farrugia G; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Beyder A; Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Wedel T; Institute of Anatomy, Christian-Albrechts-University of Kiel, Kiel, Germany., Kahlke V; Department of Proctological Surgery Park Klinik Kiel, Kiel, Germany.; Proctological Office Kiel, Kiel, Germany.; Christian-Albrechts-University of Kiel, Kiel, Germany., Schafmayer C; Department for General, Visceral, Vascular and Transplantation Surgery, University Medical Center Rostock, Rostock, Germany., D'Amato M; School of Biological Sciences, Monash University, Clayton, Victoria, Australia mdamato@cicbiogune.es a.franke@mucosa.de.; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany mdamato@cicbiogune.es a.franke@mucosa.de.; University Hospital of Schleswig-Holstein (UKSH), Kiel Campus, Kiel, Germany.

Publikováno v: Gut [Gut] 2021 Apr 22. Date of Electronic Publication: 2021 Apr 22.

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.

Autor: Kordowski F; Department of Dermatology and Allergology, University Hospital Schleswig-Holstein, University of Kiel, Rosalind-Franklin-Straße 7, 24105, Kiel, Germany., Kolarova J; Institute of Human Genetics, University of Kiel, Kiel, Germany.; Institute of Human Genetics, University of Ulm, Ulm, Germany., Schafmayer C; Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany., Buch S; Medical Department 1, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Goldmann T; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany., Marwitz S; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany., Kugler C; Thoracic Surgery, LungenClinic Grosshansdorf, Grosshansdorf, Germany., Scheufele S; Institute of Human Genetics, University of Kiel, Kiel, Germany., Gassling V; Department of Oral and Maxillofacial Surgery, University of Kiel, Kiel, Germany., Németh CG; Department of Oral and Maxillofacial Surgery, University of Kiel, Kiel, Germany., Brosch M; Medical Department 1, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Hampe J; Medical Department 1, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany., Lucius R; Anatomical Institute, University of Kiel, Kiel, Germany., Röder C; Institute for Experimental Cancer Research, University of Kiel, Kiel, Germany., Kalthoff H; Institute for Experimental Cancer Research, University of Kiel, Kiel, Germany., Siebert R; Institute of Human Genetics, University of Kiel, Kiel, Germany.; Institute of Human Genetics, University of Ulm, Ulm, Germany., Ammerpohl O; Institute of Human Genetics, University of Kiel, Kiel, Germany.; Institute of Human Genetics, University of Ulm, Ulm, Germany., Reiss K; Department of Dermatology and Allergology, University Hospital Schleswig-Holstein, University of Kiel, Rosalind-Franklin-Straße 7, 24105, Kiel, Germany. kreiss@dermatology.uni-kiel.de.

Publikováno v: BMC cancer [BMC Cancer] 2018 Aug 06; Vol. 18 (1), pp. 796. Date of Electronic Publication: 2018 Aug 06.