Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Nélio, Gonçalves"'
Autor:
Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, Joana M. Marques
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. T
Externí odkaz:
https://doaj.org/article/eb8f8fcddb564941b72eac2840610363
Autor:
Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 157, Iss , Pp 105441- (2021)
Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A
Externí odkaz:
https://doaj.org/article/218cea5ef5a84400aaea77837c4e90ac
Autor:
Liliana Dias, Daniela Pochmann, Cristina Lemos, Henrique B. Silva, Joana I. Real, Francisco Q. Gonçalves, Daniel Rial, Nélio Gonçalves, Ana Patrícia Simões, Samira G. Ferreira, Paula Agostinho, Rodrigo A. Cunha, Angelo R. Tomé
Publikováno v:
ACS Chemical Neuroscience. 14:1299-1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f4301063c748fa6d021ef96fe577a3
https://doi.org/10.1021/acschemneuro.2c00810
https://doi.org/10.1021/acschemneuro.2c00810
Autor:
Francisco Q. Gonçalves, Filipe C. Matheus, Henrique B. Silva, Joana I. Real, Daniel Rial, Ricardo J. Rodrigues, Jean-Pierre Oses, António C. Silva, Nélio Gonçalves, Rui D. Prediger, Ângelo R. Tomé, Rodrigo A. Cunha
Publikováno v:
Molecular Neurobiology. 60:1659-1674
Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in Parkinson’s disease (PD) is unclear and was now investigated. ATP was particularly released at high stimulation intensities from purified striatal nerve termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af30f240f48859a31ff1f9ecd3db373
https://doi.org/10.1007/s12035-022-03162-1
https://doi.org/10.1007/s12035-022-03162-1
Autor:
Francisco Q. Gonçalves, João P. Lopes, Henrique B. Silva, Cristina Lemos, António C. Silva, Nélio Gonçalves, Ângelo R. Tomé, Samira G. Ferreira, Paula M. Canas, Daniel Rial, Paula Agostinho, Rodrigo A. Cunha
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Adenosine A2A receptors (A2AR) overfunction causes synaptic and memory dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ1-42)-based model of early AD, we now unraveled that this involves an increased synaptic release of ATP coupled
Externí odkaz:
https://doaj.org/article/5afe45d9cdb74873aa61a2ff27b5edf9
Autor:
Douglas T. Leffa, Pablo Pandolfo, Nélio Gonçalves, Nuno J. Machado, Carolina M. de Souza, Joana I. Real, António C. Silva, Henrique B. Silva, Attila Köfalvi, Rodrigo A. Cunha, Samira G. Ferreira
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Adenosine A2A receptors (A2ARs) were recently described to control synaptic plasticity and network activity in the prefrontal cortex (PFC). We now probed the role of these PFC A2AR by evaluating the behavioral performance (locomotor activity, anxiety
Externí odkaz:
https://doaj.org/article/7f828bbc6a6b4a82be3384e5d9ff7c7c
Publikováno v:
Pharmaceuticals, Vol 14, Iss 1, p 60 (2021)
Cancer, one of the most mortal diseases worldwide, is characterized by the gain of specific features and cellular heterogeneity. Clonal evolution is an established theory to explain heterogeneity, but the discovery of cancer stem cells expanded the c
Externí odkaz:
https://doaj.org/article/6a5efe0a5bb1430abdd1dc3bb3f6f401
Autor:
Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha, Christophe Mulle
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memo
Externí odkaz:
https://doaj.org/article/1ea75979789f4071b6f94deca86c19df
Autor:
Xinli, Xu, Rui O, Beleza, Francisco Q, Gonçalves, Sergio, Valbuena, Sofia, Alçada-Morais, Nélio, Gonçalves, Joana, Magalhães, João M M, Rocha, Sofia, Ferreira, Ana S G, Figueira, Juan, Lerma, Rodrigo A, Cunha, Ricardo J, Rodrigues, Joana M, Marques
Publikováno v:
Scientific reports. 12(1)
The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. The molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79617717669f17148ade6d711e903b68
https://pubmed.ncbi.nlm.nih.gov/36038626
https://pubmed.ncbi.nlm.nih.gov/36038626
Autor:
Ângela Valério-Fernandes, Nuno A. Fonseca, Nélio Gonçalves, Ana F. Cruz, Marta I. Pereira, Ana C. Gregório, Vera Moura, Ana F. Ladeirinha, Ana Alarcão, Joana Gonçalves, Antero Abrunhosa, Joana B. Melo, Lina Carvalho, Sérgio Simões, João N. Moreira
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2217
Notwithstanding the advances in the treatment of lung cancer with immune checkpoint inhibitors, the high percentage of non-responders supports the development of novel anticancer treatments. Herein, the expression of the onco-target nucleolin in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b94fbb5367248e7a9645a793bf1171
https://pubmed.ncbi.nlm.nih.gov/35565346
https://pubmed.ncbi.nlm.nih.gov/35565346