Výsledky vyhledávání - "N, van den Hout"

Akademický článek

Split Pool Ligation-based Single-cell Transcriptome sequencing (SPLiT-seq) data processing pipeline comparison

Autor: Lucas Kuijpers, Bastian Hornung, Mirjam C. G. N. van den Hout - van Vroonhoven, Wilfred F. J. van IJcken, Frank Grosveld, Eskeatnaf Mulugeta

Publikováno v: BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)

Abstract Background Single-cell sequencing techniques are revolutionizing every field of biology by providing the ability to measure the abundance of biological molecules at a single-cell resolution. Although single-cell sequencing approaches have be

Externí odkaz: https://doaj.org/article/2529024ff6db4061927e54fffe6e9d30

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Akademický článek

Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells.

Autor: Danny Noack, Mirjam C G N van den Hout, Carmen W E Embregts, Wilfred F J van IJcken, Marion P G Koopmans, Barry Rockx

Publikováno v: PLoS Neglected Tropical Diseases, Vol 18, Iss 3, p e0012074 (2024)

Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome (HFRS) in humans worldwide. In rats, SEOV predominantly exists as a p

Externí odkaz: https://doaj.org/article/c2da13375a5a4271b74dbeaa044b9570

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Akademický článek

Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

Autor: Ashley van der Spek, Sophie C. Warner, Linda Broer, Christopher P. Nelson, Dina Vojinovic, Shahzad Ahmad, Pascal P. Arp, Rutger W. W. Brouwer, Matthew Denniff, Mirjam C. G. N. van den Hout, Jeroen G. J. van Rooij, Robert Kraaij, Wilfred F. J. van IJcken, Nilesh J. Samani, M. Arfan Ikram, André G. Uitterlinden, Veryan Codd, Najaf Amin, Cornelia M. van Duijn

Publikováno v: Frontiers in Genetics, Vol 11 (2020)

Telomeres are important for maintaining genomic stability. Telomere length has been associated with aging, disease, and mortality and is highly heritable (∼82%). In this study, we aimed to identify rare genetic variants associated with telomere len

Externí odkaz: https://doaj.org/article/c77eae33646043f3bedc794e8a9da48a

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Akademický článek

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Akademický článek

Whole-Genome Linkage Scan Combined With Exome Sequencing Identifies Novel Candidate Genes for Carotid Intima-Media Thickness

Autor: Dina Vojinovic, Maryam Kavousi, Mohsen Ghanbari, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Wilfred F. J. van Ijcken, Andre G. Uitterlinden, Cornelia M. van Duijn, Najaf Amin

Publikováno v: Frontiers in Genetics, Vol 9 (2018)

Carotid intima-media thickness (cIMT) is an established heritable marker for subclinical atherosclerosis. In this study, we aim to identify rare variants with large effects driving differences in cIMT by performing genome-wide linkage analysis of ind

Externí odkaz: https://doaj.org/article/f622826fe6314b3f85e9b57be02f4cb0

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Akademický článek

Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element.

Autor: Jessica Zuin, Valentina Casa, Jelena Pozojevic, Petros Kolovos, Mirjam C G N van den Hout, Wilfred F J van Ijcken, Ilaria Parenti, Diana Braunholz, Yorann Baron, Erwan Watrin, Frank J Kaiser, Kerstin S Wendt

Publikováno v: PLoS Genetics, Vol 13, Iss 12, p e1007137 (2017)

Cohesin is crucial for genome stability, cell division, transcription and chromatin organization. Its functions critically depend on NIPBL, the cohesin-loader protein that is found to be mutated in >60% of the cases of Cornelia de Lange syndrome (CdL

Externí odkaz: https://doaj.org/article/9a8bee23bdc14e87a2cfaf32a9732803

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CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells

Publikováno v: Dev Cell
Nature Cell Biology, 23(8), 881-893. Nature Publishing Group

The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous CTCF in mouse embryonic stem cells with green-fluorescen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dfc5062424a1bb8d40df0bdfc26739
https://doi.org/10.1038/s41556-021-00722-w

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Akademický článek

Exome-Wide Meta-Analysis Identifies Rare 3′-UTR Variant in ERCC1/CD3EAP Associated with Symptoms of Sleep Apnea

Autor: Ashley van der Spek, Annemarie I. Luik, Desana Kocevska, Chunyu Liu, Rutger W. W. Brouwer, Jeroen G. J. van Rooij, Mirjam C. G. N. van den Hout, Robert Kraaij, Albert Hofman, André G. Uitterlinden, Wilfred F. J. van IJcken, Daniel J. Gottlieb, Henning Tiemeier, Cornelia M. van Duijn, Najaf Amin

Publikováno v: Frontiers in Genetics, Vol 8 (2017)

Obstructive sleep apnea (OSA) is a common sleep breathing disorder associated with an increased risk of cardiovascular and cerebrovascular diseases and mortality. Although OSA is fairly heritable (~40%), there have been only few studies looking into

Externí odkaz: https://doaj.org/article/1e16562df169475887bc3121dd3732eb

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Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome

Autor: Judith C. Birkhoff, Anne L. Korporaal, Rutger W. W. Brouwer, Karol Nowosad, Claudia Milazzo, Lidia Mouratidou, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Danny Huylebroeck, Andrea Conidi

Publikováno v: Genes
Volume 14
Issue 3
Pages: 629

Perturbation and mechanistic studies have shown that the DNA-binding transcription factor Zeb2 controls cell fate decision, differentiation and/or maturation in multiple cell lineages in embryos and after birth. In cultured embryonic stem cells (ESCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c04ed20f884b4e7c40d20607ddae14
https://doi.org/10.3390/genes14030629

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Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency

Autor: Wilfred F. J. van IJcken, Marja W. Wessels, Zakia Azmani, Steven Coyne, Sjaak Philipsen, Nynke Gillemans, Rutger W W Brouwer, Stella A. de Man, Kirsten van Lom, Ryo Kurita, Mirjam C G N van den Hout, Daniel E. Bauer, Marjon H. Cnossen, Divya S. Vinjamur, Thamar B. van Dijk, Yukio Nakamura, Rolph Pfundt, K L Juliëtte Schmidt

Publikováno v: Blood Advances, 5, 9, pp. 2339-2349
Blood Adv
Blood Advances, 5, 2339-2349
Blood advances, 5(9), 2339-2349. American Society of Hematology

The BCL11A gene encodes a transcriptional repressor with essential functions in multiple tissues during human development. Haploinsufficiency for BCL11A causes Dias-Logan syndrome (OMIM 617101), an intellectual developmental disorder with hereditary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2a63d43b032e913ad9abb5c17e571f
https://repository.ubn.ru.nl/handle/2066/233970

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