Zobrazeno 1 - 10
of 649
pro vyhledávání: '"N, van Leeuwen"'
IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia
Autor:
Britt M. T. Vervoort, Miriam Butler, Kari J.T. Grünewald, Dorette S. van Ingen Schenau, Trisha M. Tee, Luc Lucas, Alwin D. R. Huitema, Judith M. Boer, Beat C. Bornhauser, Jean-Pierre Bourquin, Peter M. Hoogerbrugge, Vincent H.J. van der Velden, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
IKZF1-deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1-loss on sensitivity to drugs used in contemporary treatment protocols has remained under
Externí odkaz:
https://doaj.org/article/70f5749bff5943bb9814e9df3159f0f2
Autor:
Annelienke M. van Hulst, Jordy C.G. van der Zwet, Jessica G.C.A.M. Buijs-Gladdines, Willem K. Smits, Marta Fiocco, Rob Pieters, Frank N. van Leeuwen, Marry M. van den Heuvel-Eibrink, Erica L.T. van den Akker, Jules P.P. Meijerink
Publikováno v:
Haematologica, Vol 109, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/579ba24a9a684d72832907d8045d45c9
Autor:
Willem P.J. Cox, Nils Evander, Dorette S. van Ingen Schenau, Gawin R. Stoll, Nadia Anderson, Lieke de Groot, Kari J.T. Grünewald, Rico Hagelaar, Miriam Butler, Roland P. Kuiper, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
In pediatric acute lymphoblastic leukemia (ALL), mutations/deletions affecting the TP53 gene are rare at diagnosis. However, at relapse about 12% of patients show TP53 aberrations, which are predictive of a very poor outcome. Since p53-mediated apopt
Externí odkaz:
https://doaj.org/article/986ac4b3aae24d9999fc92fcd6366f17
Autor:
Anna Østergaard, Amir Enshaei, Rob Pieters, Ajay Vora, Martin A. Horstmann, Gabriele Escherich, Bertil Johansson, Mats Heyman, Kjeld Schmiegelow, Peter M. Hoogerbrugge, Monique L. den Boer, Roland P. Kuiper, Anthony V. Moorman, Judith M. Boer, Frank N. van Leeuwen
Publikováno v:
HemaSphere, Vol 7, Iss 5, p e875 (2023)
IKZF1 deletions are an established prognostic factor in childhood acute lymphoblastic leukemia (ALL). However, their relevance in patients with good risk genetics, namely ETV6::RUNX1 and high hyperdiploid (HeH), ALL remains unclear. We assessed the p
Externí odkaz:
https://doaj.org/article/5645c5c18f97430d84ab7aaaba94a6bf
Publikováno v:
BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Instrumental variable (IV) analysis holds the potential to estimate treatment effects from observational data. IV analysis potentially circumvents unmeasured confounding but makes a number of assumptions, such as that the IV share
Externí odkaz:
https://doaj.org/article/f90933d7d3c04b22aaec38902fb658bd
Autor:
Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment. We previously reported that leukemias harboring deletions or muta
Externí odkaz:
https://doaj.org/article/bd62010cd4ac4cb38d96197bfa9e66ae
Autor:
M. A. Serge, F. Mazier, R. Fyfe, M.-J. Gaillard, T. Klein, A. Lagnoux, D. Galop, E. Githumbi, M. Mindrescu, A. B. Nielsen, A.-K. Trondman, A. Poska, S. Sugita, J. Woodbridge, D. Abel-Schaad, C. Åkesson, T. Alenius, B. Ammann, S. T. Andersen, R. Scott Anderson, M. Andrič, L. Balakauskas, L. Barnekow, V. Batalova, J. Bergman, H. John B. Birks, L. Björkman, A. E. Bjune, O. Borisova, N. Broothaerts, J. Carrion, C. Caseldine, J. Christiansen, Q. Cui, A. Currás, S. Czerwiński, R. David, A. L. Davies, R. De Jong, F. Di Rita, B. Dietre, W. Dörfler, E. Doyen, K. J. Edwards, A. Ejarque, E. Endtmann, D. Etienne, E. Faure, I. Feeser, A. Feurdean, E. Fischer, W. Fletcher, F. Franco-Múgica, E. D. Fredh, C. Froyd, S. Garcés-Pastor, I. García-Moreiras, E. Gauthier, G. Gil-Romera, P. González-Sampériz, M. J. Grant, R. Grindean, J. N. Haas, G. Hannon, A.-J. Heather, M. Heikkilä, K. Hjelle, S. Jahns, N. Jasiunas, G. Jiménez-Moreno, I. Jouffroy-Bapicot, M. Kabailienė, I. M. Kamerling, M. Kangur, M. Karpińska-Kołaczek, A. Kasianova, P. Kołaczek, P. Lagerås, M. Latalowa, J. Lechterbeck, C. Leroyer, M. Leydet, M. Lindbladh, O. Lisitsyna, J.-A. López-Sáez, John Lowe, R. Luelmo-Lautenschlaeger, E. Lukanina, L. Macijauskaitė, D. Magri, D. Marguerie, L. Marquer, A. Martinez-Cortizas, I. Mehl, J. M. Mesa-Fernández, T. Mighall, A. Miola, Y. Miras, C. Morales-Molino, A. Mrotzek, C. Muñoz Sobrino, B. Odgaard, I. Ozola, S. Pérez-Díaz, R. P. Pérez-Obiol, C. Poggi, P. Ramil Rego, M. J. Ramos-Román, P. Rasmussen, M. Reille, M. Rösch, P. Ruffaldi, M. Sanchez Goni, N. Savukynienė, T. Schröder, M. Schult, U. Segerström, H. Seppä, G. Servera Vives, L. Shumilovskikh, H. W. Smettan, M. Stancikaite, A. C. Stevenson, N. Stivrins, I. Tantau, M. Theuerkauf, S. Tonkov, W. O. van der Knaap, J. F. N. van Leeuwen, E. Vecmane, G. Verstraeten, S. Veski, R. Voigt, H. Von Stedingk, M. P. Waller, J. Wiethold, K. J. Willis, S. Wolters, V. P. Zernitskaya
Publikováno v:
Land, Vol 12, Iss 5, p 986 (2023)
Reliable quantitative vegetation reconstructions for Europe during the Holocene are crucial to improving our understanding of landscape dynamics, making it possible to assess the past effects of environmental variables and land-use change on ecosyste
Externí odkaz:
https://doaj.org/article/df11e3375ea84fa1b270af3f74f6e9b8
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background There is a growing interest in assessment of the quality of hospital care, based on outcome measures. Many quality of care comparisons rely on binary outcomes, for example mortality rates. Due to low numbers, the observed differen
Externí odkaz:
https://doaj.org/article/cc07db256f5e48feaee1d32359a9b3ee
Autor:
Axel Rosendahl Huber, Anaïs J.C. N. van Leeuwen, Flavia Peci, Jurrian K. de Kanter, Eline J.M. Bertrums, Ruben van Boxtel
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101361- (2022)
Summary: Mutational signatures have been identified in cancer genomes, providing information about the causes of cancer and treatment vulnerabilities. This protocol describes an assay to determine the genotoxic mechanisms underlying these signatures
Externí odkaz:
https://doaj.org/article/d05aa286286b467aa5b08f7de37027c0
Autor:
Arnout Jan de Beaufort, Belinda WC Ommering, Friedo W Dekker, Charlotte R den Bakker, Thed N van Leeuwen
Publikováno v:
BMJ Open, Vol 12, Iss 4 (2022)
Objectives The medical field is facing a clinician-scientist shortage. Medical schools could foster the clinician-scientist workforce by offering students research opportunities. Most medical schools offer elective research programmes. Subsequently,
Externí odkaz:
https://doaj.org/article/2f346a40a8874ae0886fffcc662e2652