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Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation

Autor: W S May, M P Carroll, Moira A. McMahon, Jerry L. Spivak, N Weich, U R Rapp

Publikováno v: Journal of Biological Chemistry. 266:14964-14969

Erythropoietin mediates the rapid phosphorylation of Raf-1 in the murine cell lines HCD-57 and FDC-P1/ER, which proliferate in response to this cytokine. Phosphorylation occurs at both serine and tyrosine residues and as such is similar to the Raf-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b39c4e74f3b8633d984e74d3ef03dbd
https://doi.org/10.1016/s0021-9258(18)98572-8

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The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites

Autor: N Weich, C Lindenthal, Volker Heussler, M Q Klinkert, Y S Chia

Publikováno v: Lindenthal, C; Weich, N; Chia, Y S; Heussler, Volker; Klinkert, M Q (2005). The proteasome inhibitor MLN-273 blocks exoerythrocytic and erythrocytic development of Plasmodium parasites. Parasitology, 131(Pt 1), pp. 37-44. Cambridge University Press 10.1017/S003118200500747X

Protein degradation is regulated during the cell cycle of all eukaryotic cells and is mediated by the ubiquitin-proteasome pathway. Potent and specific peptide-derived inhibitors of the 20S proteasome have been developed recently as anti-cancer agent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73c7a1897bbb493584505427b4426f5

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Molecular cloning and characterization of murine interleukin-11

Autor: J C, Morris, S, Neben, F, Bennett, H, Finnerty, A, Long, D R, Beier, S, Kovacic, J M, McCoy, E, DiBlasio-Smith, E R, La Vallie, A, Caruso, J, Calvetti, G, Morris, N, Weich, S R, Paul, P S, Crosier, K J, Turner, C R, Wood

Publikováno v: Experimental hematology. 24(12)

Human interleukin-11 (IL-11) has been shown to have pleiotropic action on hematopoietic, hepatic, stromal, epithelial, neural, and osteoclast cells. In the present work, the murine IL-11 cDNA has been isolated from a fetal thymic cell line, and its s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b23a057f0c82ab49b1788cb80cebb9ed
https://pubmed.ncbi.nlm.nih.gov/8913282

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Influence in vitro of IL-3/Epo fusion proteins compared with the combination of IL-3 plus Epo in enhancing the proliferation of single isolated erythroid and multipotential progenitor cells from human umbilical cord blood and adult bone marrow

Autor: L, Lu, M, Xiao, Z H, Li, L K, Jolliffe, S, Jones, H E, Broxmeyer, N, Weich

Publikováno v: Experimental hematology. 23(10)

Human interleukin-3/erythropoietin (IL-3/Epo) fusion protein have been constructed, expressed, and tested for biological activity. These fusion proteins were previously shown to be active on erythroid progenitors (BFU-E) from unseparated human bone m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e571b08a078bf383a1638642bac25a0f
https://pubmed.ncbi.nlm.nih.gov/7656932

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Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation

Autor: M P, Carroll, J L, Spivak, M, McMahon, N, Weich, U R, Rapp, W S, May

Publikováno v: The Journal of biological chemistry. 266(23)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ec97c0f06ce36b605800ef18058c2ba
https://pubmed.ncbi.nlm.nih.gov/1869534

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Relationship between globin mRNA accumulation and commitment to terminal cell differentiation in inducer sensitive and resistant erythroleukemia variants

Autor: N Weich, PA Marks, RA Rifkind

Publikováno v: Blood. 76(2)

The relationship between the kinetics of commitment to terminal cell differentiation and the rates of accumulation of globin mRNA has been examined during the induction of erythroid differentiation by polar/apolar chemical inducers in murine erythrol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0814a7015b57d0779b3db044e5cfae
https://pubmed.ncbi.nlm.nih.gov/2369636

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