Zobrazeno 1 - 10
of 2 324
pro vyhledávání: '"N, Ward"'
Autor:
K. A. Muller, P. Jiang, G. Hammond, T. Ahmadullah, H.-S. Song, R. Kukkadapu, N. Ward, M. Bowe, R. K. Chu, Q. Zhao, V. A. Garayburu-Caruso, A. Roebuck, X. Chen
Publikováno v:
Geoscientific Model Development, Vol 17, Pp 8955-8968 (2024)
Organic matter (OM) composition plays a central role in microbial respiration of dissolved organic matter and subsequent biogeochemical reactions. Here, a direct connection of organic matter chemistry and thermodynamics to reactive transport simulato
Externí odkaz:
https://doaj.org/article/b5780ff1572844a6ad552cf9aea45298
Publikováno v:
Applied Network Science, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Science is a collaborative endeavor. Yet, unlike co-authorship, interactions within and across teams are seldom reported in a structured way, making them hard to study at scale. We show that Large Language Models (LLMs) can solve this proble
Externí odkaz:
https://doaj.org/article/f059d0c67e204a60b4be314a0a6da5cc
Autor:
Emily H. Xiong, Xiang Zhang, Huijuan Yan, Henry N. Ward, Zhen-Yuan Lin, Cassandra J. Wong, Ci Fu, Anne-Claude Gingras, Suzanne M. Noble, Nicole Robbins, Chad L. Myers, Leah E. Cowen
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114601- (2024)
Summary: Fungal pathogens such as Candida albicans pose a significant threat to human health with limited treatment options available. One strategy to expand the therapeutic target space is to identify genes important for pathogen growth in host-rele
Externí odkaz:
https://doaj.org/article/7a90d14f55eb4540a12239260d52e408
Autor:
C. Lønborg, C. Carreira, G. Abril, S. Agustí, V. Amaral, A. Andersson, J. Arístegui, P. Bhadury, M. B. Bif, A. V. Borges, S. Bouillon, M. Ll. Calleja, L. C. Cotovicz Jr., S. Cozzi, M. Doval, C. M. Duarte, B. Eyre, C. G. Fichot, E. E. García-Martín, A. Garzon-Garcia, M. Giani, R. Gonçalves-Araujo, R. Gruber, D. A. Hansell, F. Hashihama, D. He, J. M. Holding, W. R. Hunter, J. S. P. Ibánhez, V. Ibello, S. Jiang, G. Kim, K. Klun, P. Kowalczuk, A. Kubo, C.-W. Lee, C. B. Lopes, F. Maggioni, P. Magni, C. Marrase, P. Martin, S. L. McCallister, R. McCallum, P. M. Medeiros, X. A. G. Morán, F. E. Muller-Karger, A. Myers-Pigg, M. Norli, J. M. Oakes, H. Osterholz, H. Park, M. Lund Paulsen, J. A. Rosentreter, J. D. Ross, D. Rueda-Roa, C. Santinelli, Y. Shen, E. Teira, T. Tinta, G. Uher, M. Wakita, N. Ward, K. Watanabe, Y. Xin, Y. Yamashita, L. Yang, J. Yeo, H. Yuan, Q. Zheng, X. A. Álvarez-Salgado
Publikováno v:
Earth System Science Data, Vol 16, Pp 1107-1119 (2024)
Measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) concentrations are used to characterize the dissolved organic matter (DOM) pool and are important components of biogeochemical cycling in the coastal ocean. Here, we
Externí odkaz:
https://doaj.org/article/383f2eb164ce4f6cb27c27043aa517c1
Autor:
Kevin Lin, Ya-Chu Chang, Maximilian Billmann, Henry N. Ward, Khoi Le, Arshia Z. Hassan, Urvi Bhojoo, Katherine Chan, Michael Costanzo, Jason Moffat, Charles Boone, Anja-Katrin Bielinsky, Chad L. Myers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Current approaches to define chemical-genetic interactions (CGIs) in human cell lines are resource-intensive. We designed a scalable chemical-genetic screening platform by generating a DNA damage response (DDR)-focused custom sgRNA library t
Externí odkaz:
https://doaj.org/article/3b9ce5f7b8554685b2e0afb2fc4f3cce
Autor:
Arshia Zernab Hassan, Henry N Ward, Mahfuzur Rahman, Maximilian Billmann, Yoonkyu Lee, Chad L Myers
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 11, Pp n/a-n/a (2023)
Abstract CRISPR‐Cas9 screens facilitate the discovery of gene functional relationships and phenotype‐specific dependencies. The Cancer Dependency Map (DepMap) is the largest compendium of whole‐genome CRISPR screens aimed at identifying cancer
Externí odkaz:
https://doaj.org/article/becc7c92c97a46618bd84cf4cd986a98
Autor:
Edward N. Ward, Lisa Hecker, Charles N. Christensen, Jacob R. Lamb, Meng Lu, Luca Mascheroni, Chyi Wei Chung, Anna Wang, Christopher J. Rowlands, Gabriele S. Kaminski Schierle, Clemens F. Kaminski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Structured Illumination Microscopy allows for the visualization of biological structures at resolutions below the diffraction limit, but this imaging modality is still hampered by high experimental complexity. Here, the authors present a combination
Externí odkaz:
https://doaj.org/article/66f1b12be34640339d1e4a7bd953ad1d
Autor:
Miriam Weckener, Laura S. Woodward, Bradley R. Clarke, Huanting Liu, Philip N. Ward, Audrey Le Bas, David Bhella, Chris Whitfield, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The enterobacterial common antigen (ECA) is a carbohydrate polymer that is associated with the cell envelope in the Enterobacteriaceae. ECA contains a repeating trisaccharide which is polymerized by WzyE, a member of the Wzy membrane protein polymera
Externí odkaz:
https://doaj.org/article/19c5542dd1c9491aa5e65f1ae1097f02
Autor:
Jiandong Huo, Halina Mikolajek, Audrey Le Bas, Jordan J. Clark, Parul Sharma, Anja Kipar, Joshua Dormon, Chelsea Norman, Miriam Weckener, Daniel K. Clare, Peter J. Harrison, Julia A. Tree, Karen R. Buttigieg, Francisco J. Salguero, Robert Watson, Daniel Knott, Oliver Carnell, Didier Ngabo, Michael J. Elmore, Susan Fotheringham, Adam Harding, Lucile Moynié, Philip N. Ward, Maud Dumoux, Tessa Prince, Yper Hall, Julian A. Hiscox, Andrew Owen, William James, Miles W. Carroll, James P. Stewart, James H. Naismith, Raymond J. Owens
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Neutralizing nanobodies (Nb) are of considerable interest as therapeutic agents for COVID-19 treatment. Here, the authors functionally and structurally characterize Nbs that bind with high affinity to the receptor binding domain of the SARS-CoV-2 spi
Externí odkaz:
https://doaj.org/article/d505e344aed84336a3d7f7d369c5238a
Autor:
Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James H. Naismith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc oct
Externí odkaz:
https://doaj.org/article/953375ccf8f24a0f97419d2d1888d0c0