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EXACERBATED AGE-RELATED OBESITY IS TEMPERED BY RENIN ANGIOTENSIN SYSTEM

Autor: P.J. Scarpace, H.Z. Toklu, D. Morgan, Erin Bruce, N. Tumer, Y. Sakarya, Christy S. Carter

Diet-induced obesity is exacerbated in senescent compared with young rats in terms of both high-fat (HF) induced weight gain and increased food consumption resulting in metabolic abnormalities, contributing to multiple age-related diseases (diabetes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa472c216b0a4a266fed1f0eae54cee0
https://europepmc.org/articles/PMC6246413/

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High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function

Autor: H Z, Toklu, J, Muller-Delp, Y, Sakaraya, S, Oktay, N, Kirichenko, M, Matheny, C S, Carter, D, Morgan, K Y E, Strehler, N, Tumer, P J, Scarpace

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 67(2)

The objective of the study was to determine the effects of a high fat (HF) diet alone or with high fructose (HF/F) on functional and structural changes in the basilar arteries and cardiovascular health parameters in rats. Male Sprague Dawley rats wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10ab575f11d84943724ff8cff0a3d790
https://pubmed.ncbi.nlm.nih.gov/27226180

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Human CCS gene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS)

Autor: Silahtaroglu, AN Brondum-Nielsen, K Gredal, O Werdelin, L and Panas, M Petersen, MB Tommerup, N Tumer, Z

Background: Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2% of sporadic cases the disease is due to a defect in the gene encoding th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::477e701b5892f81330a0535369f7efec
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3081726

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The effects of exercise duration on adrenal HSP72/73 induction in rats

Autor: H A, Demirel, S K, Powers, H, Naito, N, Tumer

Publikováno v: Acta physiologica Scandinavica. 167(3)

This study investigated the effects of varying durations of exercise training on heat shock proteins 72 and 73 (HSP72/73) induction in the rat adrenal gland. Female Sprague-Dawley rats (120 days old) were assigned to either a sedentary control group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf1968c2227575295d5563524d7be9d3
https://pubmed.ncbi.nlm.nih.gov/10606824

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In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin

Autor: B, Waurzyniak, E A, Schneider, N, Tumer, Y, Yanishevski, R, Gunther, L M, Chelstrom, H, Wendorf, D E, Myers, J D, Irvin, Y, Messinger, O, Ek, T, Zeren, M C, Langlie, W E, Evans, F M, Uckun

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6)

We evaluated the TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunotoxin in both murine and nonhuman primate models. TXU-PAP caused dose-limiting cardiac toxicity in BALB/c mice. In a SCID mouse model of invariably fatal human T-lineage acute lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2eef8cf4a3af580fb043ac6e2518be51
https://pubmed.ncbi.nlm.nih.gov/9815763

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Pharmacokinetic features, immunogenicity, and toxicity of B43(anti-CD19)-pokeweed antiviral protein immunotoxin in cynomolgus monkeys

Autor: F M, Uckun, Y, Yanishevski, N, Tumer, B, Waurzyniak, Y, Messinger, L M, Chelstrom, E A, Lisowski, O, Ek, T, Zeren, H, Wendorf, M C, Langlie, J D, Irvin, D E, Myers, G B, Fuller, W, Evans, R, Gunther

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(3)

We studied the pharmacokinetic features, immunogenicity, and toxicity of B43-pokeweed antiviral protein (PAP) immunotoxin in 13 cynomolgus monkeys. The disposition of B43-PAP in two monkeys, when administered as a single i.v. bolus dose, was characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::901687f39f9f57c042b554c797d0e3a7
https://pubmed.ncbi.nlm.nih.gov/9815689

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Fructose-induced leptin resistance involves impaired AMPK but intact STAT3 signaling

Autor: Kevin Y.E. Strehler, Alexandra Shapiro, N. Tumer, P.J. Scarpace, D. Ryder

Publikováno v: Appetite. 57:S40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6537deed64b7482170cbfef3389627c4
https://doi.org/10.1016/j.appet.2011.05.269

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Hypozincemia in nephrotic syndrome

Autor: N, Tumer, S, Baskan, A, Arcasoy, A O, Cavdar, M, Ekin

Publikováno v: Clinical nephrology. 35(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2ff8b3df79e5f01f24ec9c1ea42079e
https://pubmed.ncbi.nlm.nih.gov/2032400

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Role of calcium in adrenergic neurochemical transmission in the aging heart

Autor: J, Roberts, M L, Mortimer, P J, Ryan, M D, Johnson, N, Tumer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 253(3)

The effect of modification of extracellular Ca2+ concentration ([Ca2+]0), the administration of the neuronal Ca2+ channel blocker, omega-conotoxin, and the calcium (Ca2+) ionophore, ionomycin, were examined in the isolated heart of male Fisher-344 ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31f24d139baccd8d5b30095f5ee30793
https://pubmed.ncbi.nlm.nih.gov/2359031

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