Zobrazeno 1 - 10
of 387
pro vyhledávání: '"N, Sarvetnick"'
Publikováno v:
The Journal of Immunology. 159:4620-4627
The nonobese diabetic (NOD) mouse spontaneously develops T cell-dependent autoimmune diabetes. Here, we investigate the role of CD40 ligand (CD40L)-CD40 costimulation in the initiation and progression of this disease. Anti-CD40L mAb treatment of 3- t
Publikováno v:
The Journal of Immunology. 159:1599-1603
Cell-mediated tissue destruction, such as that occurring in allograft rejection, is thought to be mediated by Th1 cells and cytokines. We have recently shown that transgenic expression of the Th2 cytokine IL-4 by pancreatic beta cells completely prot
Publikováno v:
Diabetes. 44:1161-1164
Autor:
K Geiger, N Sarvetnick
Publikováno v:
The Journal of Immunology. 153:5239-5246
The eye represents an immunologically privileged site with specific properties mediated by immunosuppressive constituents of the intraocular fluids. This system, termed ACAID (anterior chamber-associated immune deviation), was originally attributed t
Induction of vascular addressins and adhesion molecules in the pancreas of IFN-gamma transgenic mice
Autor:
M S Lee, N Sarvetnick
Publikováno v:
The Journal of Immunology. 152:4597-4603
"Vascular addressins" play an important role in lymphocyte homing to chronic inflammatory areas. However, it is not yet known which cytokines induce vascular addressins and other adhesion molecules in vivo. Because IFN-gamma induces adhesion molecule
Publikováno v:
Scandinavian journal of immunology. 55(5)
Autoimmune diseases are chronic conditions resulting from a loss of immunological tolerance to self-antigens. Recent observations have supported an ever-broader role for innate immune responses in directing and regulating adaptive immunity, including
Autor:
A, La Cava, N, Sarvetnick
Publikováno v:
Current directions in autoimmunity. 1
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(3)
When immunological tolerance breaks down, autoimmune destruction of insulin-producing beta cells in the pancreas can cause insulin-dependent diabetes mellitus. We previously showed that transgenic nonobese diabetic (NOD) mice expressing IL-4 in the p
Publikováno v:
Transplantation. 67(12)
The role of the cytokine, interleukin (IL)-4, in allograft rejection and protection is not clear. We have previously shown that IL-4 transgenically expressed in a pancreas allograft does not protect the allograft from rejection. Here, we analyze the
Autor:
L M, Bradley, V C, Asensio, L K, Schioetz, J, Harbertson, T, Krahl, G, Patstone, N, Woolf, I L, Campbell, N, Sarvetnick
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(5)
Migration of CD4 cells into the pancreas represents a hallmark event in the development of insulin-dependent diabetes mellitus. Th1, but not Th2, cells are associated with pathogenesis leading to destruction of islet beta-cells and disease onset. Lym