Zobrazeno 1 - 10
of 124
pro vyhledávání: '"N, Pommery"'
Publikováno v:
Natural Product Research. 20:909-916
From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified. This is the first report of these compounds in this spec
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 73:411-417
The arachidonic acid metabolizing enzymes, the cyclooxygenases (COXs) and lipoxygenases (LOXs), have been implicated in the development of a variety of cancers and numerous new therapeutic inhibitors are currently under investigation. However, given
Autor:
N. Pommery, J.-P. Hénichart
Publikováno v:
Annales Pharmaceutiques Françaises. 63:69-75
Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified. Acqu
Autor:
Caroline Charlier, Laurence Goossens, François Durant, Aurelie Telliez, Jean-François Goossens, Jean Pommery, R. Houssin, N Pommery, Thierry Taverne, Jean-Pierre Henichart
Publikováno v:
Journal of Medicinal Chemistry. 47:6195-6206
The arachidonic acid metabolizing enzymes cyclooxygenase-2 (COX-2) and lipoxygenases (LOXs) have been found to be implicated in a variety of cancers, including prostate cancer. To develop new therapeutic treatments, it therefore seemed interesting to
Antioxidant defence capacity modulation of two human cell lines by amiodarone and desethylamiodarone
Publikováno v:
Toxicology in Vitro. 11:209-216
Although the role of oxidative stress has recently been the subject of increased discussion in relation to the pathogenesis of amiodarone (AMIO) toxicity, the cellular mechanisms underlying the hepatic and pulmonary disorders remain unknown. In order
Autor:
N, Pommery, J-P, Hénichart
Publikováno v:
Annales pharmaceutiques francaises. 63(1)
Because of the unavailability of effective therapies to block or reverse the progression of androgen-independent prostate cancer, it seems obvious to target growth signaling pathways for which frequently recurring mutations have been identified. Acqu
Publikováno v:
Anti-cancer drug design. 13(8)
The mitogenic action of EGF is mediated by ligand-induced autophosphorylation of the EGF receptor (EGF-R), which is commonly overexpressed in numerous human cancers. Inhibitors of receptor tyrosine kinase (RTK) activity could therefore be considered
Publikováno v:
Anti-cancer drug design. 12(6)
A combilexin molecule containing two netropsin moieties attached to the aminoalkyl side chains of mitoxantrone has been synthesized and evaluated for cytotoxic activity towards murine L1210 leukaemia and human MCF7 carcinoma cells in vitro. It is mar
Publikováno v:
Journal of chromatography. B, Biomedical applications. 657(1)
The efficiency of ion-pair reversed-phase HPLC on a Vydac C 18 column with 50 m M ammonium acetate (pH 4.75)—methanol—acetonitrile (88:9:3, v/v/v) as the mobile phase with isocratic separation and fluorescence detection for the determination of c
Autor:
N, Mestdagh, N, Pommery, J M, Saucier, B, Hecquet, C, Fournier, C, Slomianny, E, Teissier, J P, Hénichart
Publikováno v:
Anticancer research. 14(3A)
Resistance to antineoplastic drugs has often been associated with P-glycoprotein overexpression, this certainly being not the sole mechanism. In order to characterize resistance to doxorubicin and cisplatin, we have analysed P-glycoprotein expression