Výsledky vyhledávání - "N, Polentarutti"

Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells

Autor: E, Faure, O, Equils, P A, Sieling, L, Thomas, F X, Zhang, C J, Kirschning, N, Polentarutti, M, Muzio, M, Arditi

Publikováno v: The Journal of biological chemistry. 275(15)

A missense mutation in the cytoplasmic domain of the Toll-like receptor-4 (TLR-4) has been identified as the defect responsible for lipopolysaccharide (LPS) hyporesponsiveness in C3H/HeJ mice. TLR-4 and TLR-2 have recently been implicated in LPS sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aaedb8a4a49d3e13d0a6e3e783716926
https://pubmed.ncbi.nlm.nih.gov/10753909

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A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1

Autor: M, Sironi, A, Guglielmotti, N, Polentarutti, F, Fioretti, C, Milanese, M, Romano, C, Vigini, I, Coletta, S, Sozzani, S, Bernasconi, A, Vecchi, M, Pinza, A, Mantovani

Publikováno v: European cytokine network. 10(3)

Blocking chemokine production or action is a major target for pharmacological intervention in different human diseases. Bindarit (2-methyl-2-[[1-(phenylmethyl)-1H-indazol-3yl]methoxy]propan oic acid) dose-dependently inhibited MCP-1 and TNF-alpha pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd44f6f55abbceb401b037c90717bbe1
https://pubmed.ncbi.nlm.nih.gov/10477401

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Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils

Autor: R, Bonecchi, N, Polentarutti, W, Luini, A, Borsatti, S, Bernasconi, M, Locati, C, Power, A, Proudfoot, T N, Wells, C, Mackay, A, Mantovani, S, Sozzani

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(1)

Human neutrophils (polymorphonuclear leukocytes; PMN) respond to some CXC chemokines but do not migrate to CC chemokines. Recent work has shown that chemokine receptors can be modulated by inflammatory cytokines. In this study, the effect of IFN-gamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9e91b93e1ba3037981538f76617d568
https://pubmed.ncbi.nlm.nih.gov/9886422

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Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-gamma

Autor: G, Penton-Rol, N, Polentarutti, W, Luini, A, Borsatti, R, Mancinelli, A, Sica, S, Sozzani, A, Mantovani

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(8)

IFN-gamma is a potent activator of mononuclear phagocyte function and promotes the development of Th1 responses. Moreover, it induces and modulates chemokine production in a variety of cell types, including mononuclear phagocytes. In the present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b8ba3b1bd1fcb30635e0c855938b50d2
https://pubmed.ncbi.nlm.nih.gov/9558092

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Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes

Autor: N, Polentarutti, G, Picardi, A, Basile, S, Cenzuales, A, Rivolta, C, Matteucci, G, Peri, A, Mantovani, M, Introna

Publikováno v: European journal of immunology. 28(2)

PTX3 is a prototypic long pentraxin expressed by various cell types, most prominently monocytes and endothelial cells, in response to interleukin-1 (IL-1), tumor necrosis factor (TNF) and bacterial products. In the present report, we show that interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d2dbb79a6ad85cf1951d227c4a582ad
https://pubmed.ncbi.nlm.nih.gov/9521058

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Expression of monocyte chemotactic protein-3 in human monocytes and endothelial cells

Autor: N, Polentarutti, M, Introna, S, Sozzani, R, Mancinelli, G, Mantovani, A, Mantovani

Publikováno v: European cytokine network. 8(3)

Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to investigate whether human endothelial cells (EC) and, by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1560db06d21db2ccf80e1df1043a072
https://pubmed.ncbi.nlm.nih.gov/9346360

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IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences

Autor: N, Polentarutti, P, Allavena, G, Bianchi, G, Giardina, A, Basile, S, Sozzani, A, Mantovani, M, Introna

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(6)

NK cells migrate in response to C-C chemokines, including monocyte chemotactic protein-1 (MCP-1) and MCP-3. Increased migration was observed in IL-2-activated NK cells. It was therefore of interest to define the expression in resting and activated NK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a4ca8135de447047cd85cc7162a40e8
https://pubmed.ncbi.nlm.nih.gov/9058802

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Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes

Autor: F, Colotta, A, Borré, J M, Wang, M, Tattanelli, F, Maddalena, N, Polentarutti, G, Peri, A, Mantovani

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 148(3)

The present study was designed to investigate the capacity of human mononuclear phagocytes to produce a cytokine chemotactic for monocytes (monocyte chemotactic protein (MCP), alternative acronyms JE, monocyte chemotactic and activating factor, MCP-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15ba9463d04db12e9dcc6413836b6646
https://pubmed.ncbi.nlm.nih.gov/1370516

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