Zobrazeno 1 - 10
of 956
pro vyhledávání: '"N, Pavlakis"'
Leveraging long-acting IL-15 agonists for intratumoral delivery and enhanced antimetastatic activity
Autor:
John A. Hangasky, Rocío del Valle Fernández, Dimitris Stellas, Guillermo Hails, Sevasti Karaliota, Gary W. Ashley, Barbara K. Felber, George N. Pavlakis, Daniel V. Santi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionIL-15 agonists hold promise as immunotherapeutics due to their ability to induce the proliferation and expansion of cytotoxic immune cells including natural killer (NK) and CD8+ T cells. However, they generally have short half-lives that
Externí odkaz:
https://doaj.org/article/e43365ab5c1643469ee96abce7c5c45e
Autor:
Margherita Rosati, Evangelos Terpos, Philip Homan, Cristina Bergamaschi, Sevasti Karaliota, Ioannis Ntanasis-Stathopoulos, Santhi Devasundaram, Jenifer Bear, Robert Burns, Tina Bagratuni, Ioannis P. Trougakos, Meletios A. Dimopoulos, George N. Pavlakis, Barbara K. Felber
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCytokines and chemokines play an important role in shaping innate and adaptive immunity in response to infection and vaccination. Systems serology identified immunological parameters predictive of beneficial response to the BNT162b2 mRNA
Externí odkaz:
https://doaj.org/article/ff1d4f55bab147a9957e93a1589ed53e
Autor:
Kevin Conlon, Robert Wesolowski, Douglas G McNeel, John A Thompson, Rom Leidner, Andrea Wang-Gillam, Sumati Gupta, Nancy Lewis, George N Pavlakis, Lang Ho Lee, Monica Chaudhari, Nadia Hassounah, Jong Bong Lee, Jessica A O’Keeffe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Preclinically, interleukin-15 (IL-15) monotherapy promotes antitumor immune responses, which are enhanced when IL-15 is used in combination with immune checkpoint inhibitors (ICIs). This first-in-human study investigated NIZ985, a recombin
Externí odkaz:
https://doaj.org/article/2886323ab834455e8737872e76203efc
Autor:
Dimitris Stellas, Sevasti Karaliota, Vasiliki Stravokefalou, Matthew Angel, Bethany A. Nagy, Katherine C. Goldfarbmuren, Cristina Bergamaschi, Barbara K. Felber, George N. Pavlakis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112501- (2023)
Summary: Locoregional monotherapy with heterodimeric interleukin (IL)-15 (hetIL-15) in a triple-negative breast cancer (TNBC) orthotopic mouse model resulted in tumor eradication in 40% of treated mice, reduction of metastasis, and induction of immun
Externí odkaz:
https://doaj.org/article/9e387cab5379408199dc1ddc4d8c3d48
Autor:
Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, James I. Mullins, Hans-Peter Kiem, Deborah Heydenburg Fuller, Christopher W. Peterson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which facilitates viral escap
Externí odkaz:
https://doaj.org/article/23b8184a8d714211a8e14e49ff22762b
Autor:
Hrishikesh Pandit, Antonio Valentin, Matthew Angel, Claire Deleage, Cristina Bergamaschi, Jenifer Bear, Raymond Sowder, Barbara K. Felber, George N. Pavlakis
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105929- (2023)
Summary: We employed a dose-escalation regimen in rhesus macaques to deliver glycosylated IL-7, a cytokine critical for development and maintenance of T lymphocytes. IL-7 increased proliferation and survival of T cells and triggered several chemokine
Externí odkaz:
https://doaj.org/article/d3af30d85067445a9fb29a6876052178
Autor:
Vasiliki Stravokefalou, Dimitris Stellas, Sevasti Karaliota, Bethany A. Nagy, Antonio Valentin, Cristina Bergamaschi, Konstantinos Dimas, George N. Pavlakis
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Immunotherapy has emerged as a viable approach in cancer therapy, with cytokines being of great interest. Interleukin IL-15 (IL-15), a cytokine that supports cytotoxic immune cells, has been successfully tested as an anti-cancer and anti-metastatic a
Externí odkaz:
https://doaj.org/article/2b9cb05ca9884ddbbe501fcf04cf4111
Autor:
Antonio Valentin, Cristina Bergamaschi, Margherita Rosati, Matthew Angel, Robert Burns, Mahesh Agarwal, Janina Gergen, Benjamin Petsch, Lidia Oostvogels, Edde Loeliger, Kara W. Chew, Steven G. Deeks, James I. Mullins, George N. Pavlakis, Barbara K. Felber
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens develop
Externí odkaz:
https://doaj.org/article/b7a5928e7818420ea6f7a20ebbe0d915
Autor:
Ioannis P. Trougakos, Kimon Stamatelopoulos, Evangelos Terpos, Ourania E. Tsitsilonis, Evmorfia Aivalioti, Dimitrios Paraskevis, Efstathios Kastritis, George N. Pavlakis, Meletios A. Dimopoulos
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-18 (2021)
Abstract Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying pathobiology of COVID-19 will support the design of rational treatments targeting the life cycle of the virus and/or the adverse effects (e.g., multi-
Externí odkaz:
https://doaj.org/article/8cef7de791814f3eaae26fb8b50f8d78
Autor:
Cristina Bergamaschi, Maria Pagoni, Margherita Rosati, Matthew Angel, Ifigeneia Tzannou, Margarita Vlachou, Ismini Darmani, Amirah Ullah, Jenifer Bear, Santhi Devasundaram, Robert Burns, Ioannis Baltadakis, Stavros Gigantes, Meletios-Athanasios Dimopoulos, George N. Pavlakis, Evangelos Terpos, Barbara K. Felber
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunocompromised individuals including patients with hematological malignancies constitute a population at high risk of developing severe disease upon SARS-CoV-2 infection. Protection afforded by vaccination is frequently low and the biology leading
Externí odkaz:
https://doaj.org/article/829c9e52bad24897b4670efd3ea44bb5