Zobrazeno 1 - 10
of 210
pro vyhledávání: '"N, Patwardhan"'
Autor:
Jared S. Ginsberg, M. Mehdi Jadidi, Jin Zhang, Cecilia Y. Chen, Nicolas Tancogne-Dejean, Sang Hoon Chae, Gauri N. Patwardhan, Lede Xian, Kenji Watanabe, Takashi Taniguchi, James Hone, Angel Rubio, Alexander L. Gaeta
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Polar crystals can be driven into collective oscillations by optical fields tuned to precise resonance frequencies. As the amplitude of the excited phonon modes increases, novel processes scaling non-linearly with the applied fields begin to
Externí odkaz:
https://doaj.org/article/dc3871072ba54096af2e6b550311add6
Autor:
Jesse Davila-Calderon, Neeraj N. Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa R. Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda E. Hargrove, Blanton S. Tolbert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabiliz
Externí odkaz:
https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef7
Akademický článek
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Publikováno v:
Annals of the Royal College of Surgeons of England.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f836232eeeeda880dd1a3335dbb01c0d
https://pubmed.ncbi.nlm.nih.gov/36476044
https://pubmed.ncbi.nlm.nih.gov/36476044
Autor:
A. Kale, M. Aggarwal, S. Sundaram, S. Giri, N. Patwardhan, L. Garg, M. Kuruthukulangara, M. Satai, A. Shukla
Publikováno v:
ESGE Days 2022.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::192e4b065b5174028fd8ee8e30d6abf0
https://doi.org/10.1055/s-0042-1744689
https://doi.org/10.1055/s-0042-1744689
Publikováno v:
RSC Med Chem
RNA molecules are becoming an important target class in drug discovery. However, the principles for designing RNA-binding small molecules are yet to be fully uncovered. In this study, we examined the Protein Data Bank (PDB) to highlight privileged in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f3f6dbfd7daa91d5a740e6d36319a0
https://doi.org/10.1039/d0md00167h
https://doi.org/10.1039/d0md00167h
Autor:
Qi Zhang, Amanda E. Hargrove, Bo Zhao, Neeraj N. Patwardhan, Christopher S. Eubanks, Rhese D. Thompson
Publikováno v:
Journal of the American Chemical Society. 141:5692-5698
Conformational changes in RNA play vital roles in the regulation of many biological systems, yet these changes can be challenging to visualize. Previously, we demonstrated that Pattern Recognition of RNA by Small Molecules (PRRSM) can unbiasedly clus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72df843c20b4c8faf014f67bd4a35f6
https://doi.org/10.1021/jacs.8b09665
https://doi.org/10.1021/jacs.8b09665
Publikováno v:
Org Biomol Chem
Noncoding RNAs are increasingly promising drug targets yet ligand design is hindered by a paucity of methods that reveal driving factors in selective small molecule : RNA interactions, particularly given the difficulties of high-resolution structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2264a0f6fe69010be1c03b70640003
https://doi.org/10.1039/c9ob01702j
https://doi.org/10.1039/c9ob01702j
Publikováno v:
Organic & Biomolecular Chemistry. 17:1778-1786
A prominent hurdle in developing small molecule probes against RNA is the relative scarcity of general screening methods. In this study, we demonstrate the application of a fluorescent peptide displacement assay to screen small molecule probes agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886fea76896b3be86bb4630295a23cd2
https://doi.org/10.1039/c8ob02467g
https://doi.org/10.1039/c8ob02467g
Autor:
Andrew Sugarman, Amanda E. Hargrove, Gary Brewer, Jesse Davila-Calderon, Zhengguo Cai, Mei Ling Li, Penutmutchu, Liang-Yuan Chiu, Neeraj N. Patwardhan, Blanton S. Tolbert
We herein report an RNA-targeting antiviral small molecule that reduces replication of the human enterovirus 71 (EV71) via stabilization of an inhibitory small molecule-RNA-protein ternary complex. The EV71 virus poses serious threats to human health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd336bdf8991ba2ba769c5c3fe47812
