Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

Autor: Saija Haapa-Paananen, Karin Mühlbacher, Anna M. Katschnig, Søren Brunak, David Westergaard, Branka Radic-Sarikas, Maximilian Kauer, Dave N. T. Aryee, Cornelia N. Mutz, Raphaela Schwentner, Kristiina Iljin, Vidal Fey, Giulio Superti-Furga, Jeffrey A. Toretsky, Heinrich Kovar, Kalliopi Tsafou

Publikováno v: Tsafou, K, Katschnig, A M, Radic-Sarikas, B, Mutz, C N, Iljin, K, Schwentner, R, Kauer, M O, Mühlbacher, K, Aryee, D N T, Westergaard, D, Haapa-Paananen, S, Fey, V, Superti-Furga, G, Toretsky, J, Brunak, S & Kovar, H 2018, ' Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers ', OncoTarget, vol. 9, no. 57, pp. 31018-31031 . https://doi.org/10.18632/oncotarget.25760
Oncotarget
Tsafou, K, Katschnig, A M, Radic-Sarikas, B, Mutz, C N, Iljin, K, Schwentner, R, Kauer, M O, Mühlbacher, K, Aryee, D N T, Westergaard, D, Haapa-Paananen, S, Fey, V, Superti-Furga, G, Toretsky, J, Brunak, S & Kovar, H 2018, ' Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers ', Oncotarget, vol. 9, no. 57, pp. 31018-31031 . https://doi.org/10.18632/oncotarget.25760

Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the genetic hallm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426ed599ed36ac1102d09f9c7fed00f6
https://doi.org/10.18632/oncotarget.25760

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities

Autor: Theodore Papamarkou, Heinrich Kovar, Kalliopi Tsafou, Keiryn L. Bennett, Kilian Huber, Giulio Superti-Furga, Branka Radic-Sarikas, Jesper V. Olsen, Kristina B. Emdal, Søren Brunak, Jeffrey A. Toretsky, Cornelia N. Mutz

Publikováno v: Radic-Sarikas, B, Tsafou, K P, Emdal, K B, Papamarkou, T, Huber, K V M, Mutz, C, Toretsky, J A, Bennett, K L, Olsen, J V, Brunak, S, Kovar, H & Superti-Furga, G 2017, ' Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities ', Molecular Cancer Therapeutics, vol. 16, no. 1, pp. 88-101 . https://doi.org/10.1158/1535-7163.MCT-16-0235

Improvements in survival for Ewing sarcoma pediatric and adolescent patients have been modest over the past 20 years. Combinations of anticancer agents endure as an option to overcome resistance to single treatments caused by compensatory pathways. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d295e77a65b282272ea221429691aed4
https://pubmed.ncbi.nlm.nih.gov/28062706

Carnitine and Lung Lavage Dipalmitoyl Phosphatidylcholine in War-Gas Injured Patients

Autor: H. Benzer, G. Pauser, A. Lohninger, E. Kaiser, N. Mutz, L. Linhart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b17a3287c69e1493b07ce0b68982af0d
https://doi.org/10.1159/000413725

Abstract 3508: EWS-FLI1 represses Rho-actin signaling via MRTFB/YAP-1/TEAD perturbation in Ewing Sarcoma

Autor: Dave N. T. Aryee, Anna M. Katschnig, Markus Linder, Cornelia N. Mutz, Heinrich Kovar, Maximilian Kauer, Javier Alonso, Raphaela Schwentner, Eleni M. Tomazou

Publikováno v: Cancer Research. 77:3508-3508

Ewing Sarcoma (EwS) is an aggressive pediatric bone tumor driven by the aberrant fusion-oncogene EWS-FLI1, which deregulates hundreds of genes by either activation (EWS-FLI1-correlated genes) or repression (EWS-FLI1-anticorrelated genes). Several EWS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc41ea7e5dd8d9f61461fd500ad1ae7c
https://doi.org/10.1158/1538-7445.am2017-3508

Shock II

Autor: G. J. Wolbink, J. W. Baars, J. Wagstaff, A. Eerenberg, C. E. Hack, R. W. Faint, M. Mythen, I. J. Mackie, S. J. Machin, C. Routsi, S. Zakynthinos, B. Haviaras, A. Mavromatis, A. Armaganidis, B. Kadas, Ch. Roussos, D. Annane, M. C. Jars-Guincestre, F. Paraire, J. C. Raphaël, L. Lind, J. Mälstam, G. Skoog, J. -L. Teboul, J. Depret, N. Leger, D. Douguet, M. Zelter, A. Mercat, Ch. Richard, F. Saulnier, A. Durocher, G. Cadelis, F. Herengt, F. Wattel, B. Kugler, K. Träger, M. Holland, Th. Schricker, M. Georgieff, R. G. J. Westendorp, A. N. Roos, R. Simons, M. Frölich, A. E. Meinders, M. Lichtwarck-Aschoff, J. Aschenbrenner, G. Zimmermann, R. Senekowitsch, U. J. Pfeiffer, G. Blümel, A. T. Lovell, G. C. Hanson, P. J. Jensen, P. K. Andersen, C. Thøgersen, J. I. Poelaert, J. A. Everaert, D. P. Vogelaers, J. M. Decruyenaere, F. A. Colardyn, A. C. Timmins, M. Giles, C. J. Hinds, N. Maynard, D. Bihari, R. Mason, G. Baldock, I. McColl, D. Mathieu, R. Neviere, M. Fleyfel, J. Zaknun, L. Fridrich, D. Heute, S. Dyrk, A. Stoeger, M. Seyr, N. Mutz, G. Riccabona, J. Y. Lefrant, G. Aya, J. E. de la Coussaye, B. Bassoul, J. P. Auffray, J. J. Eledjam, S. Leucht, H. W. Kisch, R. Goller, J. P. Belot, B. Valtier, D. Mottin, D. Payen, A. Rubini, Del Monte, I. Attar, E. Catena, G. Rattazzi, G. L. Alati, P. Polisca, F. Turani, M. D. Pierri, L. Sommariva, Peppo A. de Penta, D. F. Colella, E. Zupancich, P. A. Gioffrè, L. Chiariello, A. Descorps-Declère, J. Hollande, M. Beaussier, O. Mimoz, J. Duranteau, A. Edouard, K. Samii, J. N. Drault, P. Marzollo, P. Sebastiano, M. Mariotti, P. Burnier, R. Chioléro, J. -J. Goy, Y. Schütz, H. Gombotz, H. Metzler, J. Plaza, J. Berger, W. F. List, D. C. Angus, N. M. Lidsky, L. M. Dotterweich, M. R. Pinsky, P. Evrard, B. de Ruyter, A. Dive, M. Gonzalez, L. Jacquet, E. Installé

Publikováno v: Intensive Care Medicine. 18:S173-S180

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca1b800503c7b84e65e23154ff7dd2c7
https://doi.org/10.1007/bf03216361