Výsledky vyhledávání

Interrelationships between densitometric, geometric, and mechanical properties of rat femora: Inferences concerning mechanical regulation of bone modeling

Autor: Ricardo Francisco Capozza, José Luis Ferretti, Jose R. Zanchetta, N. Mondelo

Publikováno v: Journal of Bone and Mineral Research. 8:1389-1396

A compensation for differences in bone material quality by bone geometric properties in femora from two different strains of rats was previously shown by us. A feedback mechanism controlling the mechanical properties of the integrated bones was then

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74e2e53d36a0e547da43a036a4cff82
https://doi.org/10.1002/jbmr.5650081113

Zobrazit plný text záznamu

Mechanisms of Paraneoplastic Syndromes in Mice Bearing a Spontaneous Lung Adenocarcinoma

Autor: Clodoaldo Roldán García, Slobodanka Klein, M. Parma, Miriam J. Diament, N. Mondelo, E. Piccinni

Publikováno v: Tumor Biology. 20:304-311

Paraneoplastic syndromes are rarely described in animal models. It may be useful to have a suitable experimental model to study the mechanisms by which they are produced. In this study, we describe a murine lung adenocarcinoma, P07, which presents hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2448155a07168d6d79585a0683e152
https://doi.org/10.1159/000030094

Zobrazit plný text záznamu

Mineralization- and remodeling-unrelated improvement of the post-yield properties of rat cortical bone by high doses of olpadronate

Autor: R F, Capozza, N, Mondelo, P S, Reina, L, Nocciolino, M, Meta, E J, Roldan, J L, Ferretti, G R, Cointry

Publikováno v: Journal of musculoskeletalneuronal interactions. 13(2)

Some pharmacologic effects on bone modeling may not be evident in studies of remodeling skeletons. This study analyzes some effects of olpadronate on cortical bone modeling and post-yield properties in femurs diaphyses (virtually only-modeling bones)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::793424f07fc44f001538ac51f748cc4d
https://pubmed.ncbi.nlm.nih.gov/23728105

Zobrazit plný text záznamu

Effects of large doses of olpadronate (Dimethyl-pamidronate) on mineral density, cross-sectional architecture, and mechanical properties of rat femurs

Autor: N. Mondelo, Esteban Montuori, Gustavo Roberto Cointry, Ricardo Francisco Capozza, Jose R. Zanchetta, José Luis Ferretti

Publikováno v: Bone. 16:S285-S293

As part of a safety-assessment study, doses of 8, 40, and 200 mg/kg per day, 6 days per week, of sodium olpadronate (dimethyl-APD, Me2-APD) were given by gavage to 10-week-old male and female rats during 27 weeks. Only the 200 mg/kg per day dose prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aa5fc01491383da0c99f2545dbb1d44
https://doi.org/10.1016/s8756-3282(95)80145-6

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

[Experimental effects of olpadronate and pamidronate on bone mass]

Autor: N, Mondelo, M D, Parma, V A, Peluffo, J R, Zanchetta, E, Piccinni, E, Montuori

Publikováno v: Medicina. 57

Ovariectomy and immobilization in rats have demonstrated to be useful models for osteopenia and they are considered to mimic some aspects of human osteoporosis associated with a deficit of ovarian hormones and the absence of mechanical function (disu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d839b2a3a98ed057d80bf2698b261ec8
https://pubmed.ncbi.nlm.nih.gov/9567350

Zobrazit plný text záznamu

[Preclinical toxicology of bisphosphonates]

Autor: N, Mondelo, V A, Peluffo, M D, Parma, G R, Cointry, R F, Capozza, J L, Ferretti, E, Piccinni, E, Montuori

Publikováno v: Medicina. 57

Bisphosphonates regulate bone turnover by inhibiting osteoclastic bone resorption. Due to their pharmacodynamic and pharmacokinetic characteristics, bisphosphonates have a special pharmacotoxicological profile related to their high degree of specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48202ce7aabce32c5494d7ee7230a084
https://pubmed.ncbi.nlm.nih.gov/9567361

Zobrazit plný text záznamu

[Effects of bisphosphonates on the mechanical efficiency of normal and osteopenic bones]

Autor: J L, Ferretti, G R, Cointry, R F, Capozza, N, Mondelo, V, Peluffo, A, Chiappe, M, Meta, R M, Alippi

Publikováno v: Medicina. 57

Bone mechanical competence (stiffness, strength) at organ level is determined by mechanical quality (intrinsic stiffness) and spatial distribution (macro-architecture) of bone material in cortical tissue (in every bone) and trabecular network (in ver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e125f69fc2c136585225be6e5c82d47
https://pubmed.ncbi.nlm.nih.gov/9567360

Zobrazit plný text záznamu

Intravenous olpadronate restores ovariectomy-affected bone strength. A mechanical, densitometric and tomographic (pQCT) study

Autor: Jose R. Zanchetta, G.R. Cointry, N. Mondelo, E. Montuori, J.L. Ferretti

Publikováno v: Bone. 17

Female Wistar rats aged 3 months were ovariectomized (OX, n=27). Three months later they were given i.v. doses of 150 (6), 300 (7), or 600 (6) ug/kg 2/wk of olpadronate during 12 weeks or left as OX controls (OXc). Bending fracture load of femur diap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ee9213b1a8aa32c1947267365618b2
https://pubmed.ncbi.nlm.nih.gov/8579940

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání