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Autor:
F. Marquis, C. Gueremy, Christian Renault, G. Le Fur, Marie-Christine Dubroeucq, F. Imbault, N. Mitrani, Andre Uzan
Publikováno v:
Neuropharmacology. 23:169-173
Summary Two epimer quinoline derivatives, PK 5078 and PK 7059, have been shown to be potent at releasing 5-HT from blood platelets. Moreover PK 5078 was also a potent and selective inhibitor of the uptake of 5-HT, being about 20 times as active as cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3cc8e124f10d3ac08e8e850241e0ba
https://doi.org/10.1016/s0028-3908(84)80010-6
https://doi.org/10.1016/s0028-3908(84)80010-6
Publikováno v:
Biochemical Pharmacology. 26:505-509
4-(3-Indolyl-alkyl)piperidine derivatives (LM 5005, LM 5008 and LM 5015), like clomipramine, had no or little effects on brain 5-HT but reduced brain 5-HIAA levels and 5-HT turnover, after single or chronic treatment. Brain tryptophan levels remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362ef1f15198dd92a1370988e43310f5
https://doi.org/10.1016/0006-2952(77)90325-2
https://doi.org/10.1016/0006-2952(77)90325-2
Autor:
Eduardo N. Mitrani, W. S. Bullough
Publikováno v:
British Journal of Dermatology. 99:603-610
In normal epidermis mitosis usually occurs in a plane horizontal to the dermo-epidermal junction, both daughter cells then remaining basal while an adjacent non-mitotic cell is detached from the baseline and forced distally. The evidence now indicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf19003fb57aa00df062ff23def439e
https://doi.org/10.1111/j.1365-2133.1978.tb07053.x
https://doi.org/10.1111/j.1365-2133.1978.tb07053.x
Publikováno v:
Life Sciences. 23:261-273
Mezilamine (2-methylamino-4-N-methylpiperazino-5-methylthio-6-chloropyrimidine) inhibits dopamine-sensitive adenylate cyclase in rat nucleus accumbens and striatum both in vitro and in vivo. After parenteral administration, mezilamine produces a dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f470c73d097cb47979d0ffb8f8396e0
https://doi.org/10.1016/0024-3205(78)90314-4
https://doi.org/10.1016/0024-3205(78)90314-4
Publikováno v:
Life Sciences. 23:1317-1324
When 5-HT platelet uptake was inhibited in rats by single or repeated oral administration of 4-[2-(3-indolyl)ethyl]piperidine (LM 5008), 5-hydroxy-indole-acetic acid (5-HIAA) and 5-HT platelet concentration decreased. An oral administration of LM 500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb9d3293e673e8b3ffc018fcb734a7
https://doi.org/10.1016/0024-3205(78)90389-2
https://doi.org/10.1016/0024-3205(78)90389-2
Autor:
F. Marquis, G. Le Fur, T. Phan, Andre Uzan, Marie-Claude Burgevin, A. Flamier, N. Mitrani, C. Jozefczak
Publikováno v:
Life Sciences. 32:2321-2328
A subacute treatment, 500 mg/kg I.P. twice daily during 5 days, by L-methionine provoked an increase in the Bmax of [3H]-spiperone binding in the striatum of the rat. This increase was associated to a decrease in membrane microviscosity. However in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0d08da6cb1accbaeb0355829251e63
https://doi.org/10.1016/0024-3205(83)90761-0
https://doi.org/10.1016/0024-3205(83)90761-0
Autor:
G, Le Fur, F, Imbault, N, Mitrani, F, Marquis, C, Renault, M C, Dubroeucq, C, Gueremy, A, Uzan
Publikováno v:
Neuropharmacology. 23(2A)
Two epimer quinoline derivatives, PK 5078 and PK 7059, have been shown to be potent at releasing 5-HT from blood platelets. Moreover PK 5078 was also a potent and selective inhibitor of the uptake of 5-HT, being about 20 times as active as clomiprami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee6b0a4d1ec2e3d03f0ca62e456afd0c
https://pubmed.ncbi.nlm.nih.gov/6717757
https://pubmed.ncbi.nlm.nih.gov/6717757
Publikováno v:
Acta psychiatrica Scandinavica. 75(5)
Platelet MAO activity was measured in 75 hospitalized depressed patients and in 31 healthy subjects. Plasmas post dexamethasone cortisol levels were examined in 73 patients. Results indicate that higher platelet MAO activity does not occur in all, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bf858e80e59a411c07418d14998d1c
https://pubmed.ncbi.nlm.nih.gov/3604729
https://pubmed.ncbi.nlm.nih.gov/3604729
Publikováno v:
L'Encephale. 11(3)
The association between changes in platelet MAO activity and Major Depressive Episode have been demonstrated. Cyclical changes in sex hormones serum levels had never been related with changes of MAO activity in depressed patients. Platelet MAO activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebb01f3f600cd92d479d6e1bb5738e11
https://pubmed.ncbi.nlm.nih.gov/4029076
https://pubmed.ncbi.nlm.nih.gov/4029076