Zobrazeno 1 - 10
of 360
pro vyhledávání: '"N, Macintyre"'
Autor:
Kieran C. Broder, Vera Y. Matrosova, Rok Tkavc, Elena K. Gaidamakova, Lam Thuy Vi Tran Ho, Andrew N. Macintyre, Anthony Soc, Aissata Diallo, Stephen C. Darnell, Sarah Bash, Michael J. Daly, Ann E. Jerse, George W. Liechti
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Chlamydia trachomatis infections are the most common bacterial STIs globally and can lead to serious morbidity if untreated. Development of a killed, whole-cell vaccine has been stymied by coincident epitope destruction during inactivation.
Externí odkaz:
https://doaj.org/article/22af534df9104a818f3712b548f15c5d
Autor:
Rebecca A. Leonard, Kaitlyn N. Burke, Rachel L. Spreng, Andrew N. Macintyre, Ying Tam, Mohamad-Gabriel Alameh, Drew Weissman, Nicholas S. Heaton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Influenza viruses cause substantial morbidity and mortality every year despite seasonal vaccination. mRNA-based vaccines have the potential to elicit more protective immune responses, but for maximal breadth and durability, it is desirable t
Externí odkaz:
https://doaj.org/article/f45c2481b42140e7a45c7cc1e869732c
Autor:
Tulika Singh, Andrew N. Macintyre, Thomas W. Burke, Jack Anderson, Elizabeth Petzold, Erica L. Stover, Matthew J. French, Thomas H. Oguin, Todd Demarco, Micah T. McClain, Emily R. Ko, Lawrence P. Park, Thomas Denny, Gregory D. Sempowski, Christopher W. Woods
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDysregulated host cytokine responses to SARS-CoV-2 infection are a primary cause of progression to severe disease, whereas early neutralizing antibody responses are considered protective. However, there are gaps in understanding the early
Externí odkaz:
https://doaj.org/article/9ffe9ce7cc8c4cf79e7c953067047211
Publikováno v:
SLAS Technology, Vol 28, Iss 5, Pp 361-368 (2023)
The potential immunogenicity of therapeutic human and humanized monoclonal antibodies (mAb) is a significant concern, and so preclinical testing of therapeutic mAbs routinely includes assessment of anti-drug antibody (ADA) induction. Here, we report
Externí odkaz:
https://doaj.org/article/52507ca073f64c848e02f76e94ea1a2e
Autor:
Bhavna Hora, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, Andrew N. Macintyre, Aria Arus-Altuz, Shuyi Wang, Ajay Singh, Chengyan Zhao, Nicole De Naeyer, Todd DeMarco, Cindy Kuykendall, Thaddeus Gurley, Kevin O. Saunders, Thomas Denny, M. Anthony Moody, John Misamore, Mark G. Lewis, Kevin Wiehe, Derek W. Cain, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)
Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t
Externí odkaz:
https://doaj.org/article/7dce7418af584710aa80977788fdbcd6
Autor:
Susan Tuddenham, Christina A. Stennett, Richard A. Cone, Jacques Ravel, Andrew N. Macintyre, Khalil G. Ghanem, Xin He, Rebecca M. Brotman
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Limited data suggest that personal lubricants may damage the vaginal mucosal epithelium, alter the vaginal microbiota, and increase inflammation. We compared vaginal cytokine profiles and microbiota before and after vaginal lubric
Externí odkaz:
https://doaj.org/article/4b4d917686e44c2cad4cca00c17d7a1b
Autor:
Angela Lovett, Arlene C. Seña, Andrew N. Macintyre, Gregory D. Sempowski, Joseph A. Duncan, Andreea Waltmann
Publikováno v:
Frontiers in Microbiology, Vol 12 (2022)
Neisseria gonorrhoeae infection of the female lower genital tract can present with a spectrum of phenotypes ranging from asymptomatic carriage to symptomatic cervical inflammation, or cervicitis. The factors that contribute to the development of asym
Externí odkaz:
https://doaj.org/article/43198d7e13b64835b994e5bf76aef5e6
Autor:
Ying Huang, Yujing Zou, Yiqun Jiao, Peijie Shi, Xiaoli Nie, Wei Huang, Chuanfeng Xiong, Michael Choi, Charles Huang, Andrew N. Macintyre, Amanda Nichols, Fang Li, Chuan-Yuan Li, Nancie J. MacIver, Diana M. Cardona, Todd V. Brennan, Zhiguo Li, Nelson J. Chao, Jeffrey C. Rathmell, Benny J. Chen
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen encounter. It is generally thought that glycolysis, which promotes T cell growth and clonal expansio
Externí odkaz:
https://doaj.org/article/f4704c5674ee445191424cee8c3df48c
Autor:
Dana N. Thornlow, Andrew N. Macintyre, Thomas H. Oguin, Amelia B. Karlsson, Erica L. Stover, Heather E. Lynch, Gregory D. Sempowski, Aaron G. Schmidt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Influenza virus alters glycosylation patterns on its surface exposed glycoproteins to evade host adaptive immune responses. The viral hemagglutinin (HA), in particular the H3 subtype, has increased its overall surface glycosylation since its introduc
Externí odkaz:
https://doaj.org/article/1d4b5aa96ea545c7a412bb252d295dee
Autor:
Andrew N. Macintyre, PhD, Matthew J. French, BS, Brittany R. Sanders, MS, Kristina J. Riebe, BSA, Ivo D. Shterev, PhD, Kevin Wiehe, PhD, Bhavna Hora, PhD, Tyler Evangelous, BS, Greg Dugan, DVM, J. Daniel Bourland, PhD, J. Mark Cline, DVM, PhD, DACVP, Gregory D. Sempowski, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 6, Iss 5, Pp 100677- (2021)
Purpose: Ionizing radiation causes acute damage to hematopoietic and immune cells, but the long-term immunologic consequences of irradiation are poorly understood. We therefore performed a prospective study of the delayed immune effects of radiation
Externí odkaz:
https://doaj.org/article/cf7a2c6396ce41df9f74b983fd76248e