Zobrazeno 1 - 10
of 267
pro vyhledávání: '"N, Leslie"'
Autor:
Mathew N. Leslie, Zara Sheikh, Dikaia Xenaki, Brian G. Oliver, Paul M. Young, Daniela Traini, Hui Xin Ong
Publikováno v:
Medicine in Drug Discovery, Vol 23, Iss , Pp 100194- (2024)
Emphysema is a respiratory disease that causes the progressive loss of lung extracellular matrix (ECM) organisation, subsequently undermining lung integrity and reducing lung function. Fibroblasts must constantly repair damage to the lungs to preserv
Externí odkaz:
https://doaj.org/article/d332cdbeb9d14043a60d7315344f7f8e
Autor:
Matthijs B. de Geus, Shannon N. Leslie, TuKiet Lam, Weiwei Wang, Florence Roux-Dalvai, Arnaud Droit, Pia Kivisakk, Angus C. Nairn, Steven E. Arnold, Becky C. Carlyle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a complex and heterogeneous neurodegenerative disorder with contributions from multiple pathophysiological pathways. One of the long-recognized and important features of AD is disrupted cerebral glucose metaboli
Externí odkaz:
https://doaj.org/article/3a59c8e75fa246d69d39653983e8997b
Autor:
Hadi Mahmodi, Christopher G Poulton, Mathew N Leslie, Glenn Oldham, Hui Xin Ong, Steven J Langford, Irina V Kabakova
Publikováno v:
JPhys Photonics, Vol 6, Iss 2, p 025009 (2024)
Brillouin microscopy has recently emerged as a new bio-imaging modality that provides information on the microscale mechanical properties of biological materials, cells and tissues. The data collected in a typical Brillouin microscopy experiment repr
Externí odkaz:
https://doaj.org/article/42d5e672c801489186a5e0d1f86222b3
Autor:
Holly H Black, Jessica L Hanson, Julia E Roberts, Shannon N Leslie, Will Campodonico, Christopher C Ebmeier, G Aaron Holling, Jian Wei Tay, Autumn M Matthews, Elizabeth Ung, Cristina I Lau, Alexandra M Whiteley
Publikováno v:
eLife, Vol 12 (2023)
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the mole
Externí odkaz:
https://doaj.org/article/496be42dc5534e3d8968e84acdbd3556
Autor:
Dibyadeep Datta, Shannon N. Leslie, Yury M. Morozov, Alvaro Duque, Pasko Rakic, Christopher H. van Dyck, Angus C. Nairn, Amy F. T. Arnsten
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III. Complement cascade signaling is critical in driving spine
Externí odkaz:
https://doaj.org/article/41ffea11f85e4da3bb94c0f905d4c13b
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 146 (2022)
A central characteristic of emphysematous progression is the continuous destruction of the lung extracellular matrix (ECM). Current treatments for emphysema have only addressed symptoms rather than preventing or reversing the loss of lung ECM. Nitrof
Externí odkaz:
https://doaj.org/article/160e01b14b234baeabaf3b57c7734999
Autor:
Dibyadeep Datta, Shannon N. Leslie, Elizabeth Woo, Nishita Amancharla, Ayah Elmansy, Miguel Lepe, Adam P. Mecca, Barbara S. Slusher, Angus C. Nairn, Amy F. T. Arnsten
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive dis
Externí odkaz:
https://doaj.org/article/c3772190e75c4cda940b9539cf4e6655
Autor:
Shannon N. Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S. Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T. Lam, Amy F. T. Arnsten, Angus C. Nairn
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Age is the most significant risk factor for Alzheimer’s disease (AD), and understanding its role in specific aspects of AD pathology will be critical for therapeutic development. Neurofibrillary tangles composed of hyperphosphorylated tau are a qui
Externí odkaz:
https://doaj.org/article/87564d357e044f14867f8f09be13ea2d
Autor:
Shannon N. Leslie, Dibyadeep Datta, Kyle R. Christensen, Christopher H. van Dyck, Amy F. T. Arnsten, Angus C. Nairn
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Age is the largest risk factor for Alzheimer’s disease (AD) and contributes to cognitive impairment in otherwise healthy individuals. Thus, it is critical that we better understand the risk aging presents to vulnerable regions of the brain and care
Externí odkaz:
https://doaj.org/article/79e9bc0a54fd40069af7bd4e5a5abb26
Publikováno v:
Bioengineering, Vol 8, Iss 8, p 110 (2021)
The emphysema death toll has steadily risen over recent decades, causing the disease to become the third most common cause of death worldwide in 2019. Emphysema is currently incurable and could be due to a genetic condition (Alpha-1 antitrypsin defic
Externí odkaz:
https://doaj.org/article/c1c94690286d4bb6b3af0514dba110ff