Zobrazeno 1 - 10
of 537
pro vyhledávání: '"N, Lemaitre"'
Autor:
Kristine F. Moseholm, Héléne T. Cronjé, Manja Koch, Annette L. Fitzpatrick, Oscar L. Lopez, Marcia C. de Oliveira Otto, W. T. Longstreth Jr., Andrew N. Hoofnagle, Kenneth J. Mukamal, Rozenn N. Lemaitre, Majken K. Jensen
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION Whether circulating levels of sphingolipids are prospectively associated with cognitive decline and dementia risk is uncertain. METHODS We measured 14 sphingolipid species in plasma samples from 4488 participants (mean age 76.2
Externí odkaz:
https://doaj.org/article/ebfe276994184a99bf0389a46a6ebb34
Autor:
Amanda M. Fretts, Paul N. Jensen, Colleen M. Sitlani, Andy Hoofnagle, Benjamin Lidgard, Jason G. Umans, David S. Siscovick, Irena B. King, Barbara V. Howard, Shelley A. Cole, Rozenn N. Lemaitre
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background A growing body of research indicates that associations of ceramides and sphingomyelins with mortality depend on the chain length of the fatty acid acylated to the backbone sphingoid base. We examined associations of 8 ceramide and sphingom
Externí odkaz:
https://doaj.org/article/ae8a9bcf773c4ab598ad1715e39a325f
Autor:
Kristine F. Moseholm, Jens W. Horn, Annette L. Fitzpatrick, Luc Djoussé, W. T. Longstreth, Oscar L. Lopez, Andrew N. Hoofnagle, Majken K. Jensen, Rozenn N. Lemaitre, Kenneth J. Mukamal
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundSphingolipids are implicated in neurodegeneration and neuroinflammation. We assessed the potential role of circulating ceramides and sphingomyelins in subclinical brain pathology by investigating their association with brain magnetic resona
Externí odkaz:
https://doaj.org/article/6e63ba6d2f89482193aa64e29f5ceb0d
Autor:
Chaojie Yang, Jenna Veenstra, Traci M. Bartz, Matthew C. Pahl, Brian Hallmark, Yii-Der Ida Chen, Jason Westra, Lyn M. Steffen, Christopher D. Brown, David Siscovick, Michael Y. Tsai, Alexis C. Wood, Stephen S. Rich, Caren E. Smith, Timothy D. O’Connor, Dariush Mozaffarian, Struan F. A. Grant, Floyd H. Chilton, Nathan L. Tintle, Rozenn N. Lemaitre, Ani Manichaikul
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented stron
Externí odkaz:
https://doaj.org/article/ddf869699ad642f1a57ef3ec28d71404
Autor:
Elena V. Feofanova, Michael R. Brown, Taryn Alkis, Astrid M. Manuel, Xihao Li, Usman A. Tahir, Zilin Li, Kevin M. Mendez, Rachel S. Kelly, Qibin Qi, Han Chen, Martin G. Larson, Rozenn N. Lemaitre, Alanna C. Morrison, Charles Grieser, Kari E. Wong, Robert E. Gerszten, Zhongming Zhao, Jessica Lasky-Su, NHLBI Trans-Omics for Precision Medicine (TOPMed), Bing Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of bo
Externí odkaz:
https://doaj.org/article/fd8c3eb176234d4c8fc8bb86a09934a5
Autor:
Benjamin Lidgard, Andrew N. Hoofnagle, Leila R. Zelnick, Ian H. de Boer, Amanda M. Fretts, Bryan R. Kestenbaum, Rozenn N. Lemaitre, Cassianne Robinson-Cohen, Nisha Bansal
Publikováno v:
Kidney Medicine, Vol 5, Iss 10, Pp 100708- (2023)
Rationale & Objective: Patients with chronic kidney disease (CKD) have dysfunctional high-density lipoprotein (HDL) particles that lack cardioprotective properties; altered lipid composition may be associated with these changes. To investigate HDL li
Externí odkaz:
https://doaj.org/article/3e636049ad10448eb6a8103f981495ef
Autor:
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew N. Hoofnagle, Amanda M. Fretts, William T. Longstreth, Jr., Michael G. Shlipak, David S. Siscovick, Jason G. Umans, Rozenn N. Lemaitre
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104765- (2023)
Summary: Background: Sphingolipids are a family of circulating lipids with regulatory and signaling roles that are strongly associated with both eGFR and cardiovascular disease. Patients with chronic kidney disease (CKD) are at high risk for cardiova
Externí odkaz:
https://doaj.org/article/c8863ab2b9c6472a93ed61fcec604af9
Autor:
Rozenn N. Lemaitre, Paul N. Jensen, Zeneng Wang, Amanda M. Fretts, Colleen M. Sitlani, Ina Nemet, Nona Sotoodehnia, Marcia C. de Oliveira Otto, Weifei Zhu, Matt Budoff, W. T. Longstreth, Bruce M. Psaty, David S. Siscovick, Stanley L. Hazen, Dariush Mozaffarian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 16 (2023)
Background The association of circulating trimethylamine‐N‐oxide (TMAO) with stroke has received limited attention. To address this gap, we examined the associations of serial measures of plasma TMAO with incident ischemic stroke. Methods and Res
Externí odkaz:
https://doaj.org/article/43e934b0c5ff4a778dac6634de13e4b3
Autor:
William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong, Luisa Foco, Farah Ahmed, Jennifer A. Brody, Reem Salman, Raymond Noordam, Jan-Walter Benjamins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Linda Repetto, Maria Pina Concas, Marten E. van den Berg, Stefan Weiss, Antoine R. Baldassari, Traci M. Bartz, James P. Cook, Daniel S. Evans, Rebecca Freudling, Oliver Hines, Jonas L. Isaksen, Honghuang Lin, Hao Mei, Arden Moscati, Martina Müller-Nurasyid, Casia Nursyifa, Yong Qian, Anne Richmond, Carolina Roselli, Kathleen A. Ryan, Eduardo Tarazona-Santos, Sébastien Thériault, Stefan van Duijvenboden, Helen R. Warren, Jie Yao, Dania Raza, Stefanie Aeschbacher, Gustav Ahlberg, Alvaro Alonso, Laura Andreasen, Joshua C. Bis, Eric Boerwinkle, Archie Campbell, Eulalia Catamo, Massimiliano Cocca, Michael J. Cutler, Dawood Darbar, Alessandro De Grandi, Antonio De Luca, Jun Ding, Christina Ellervik, Patrick T. Ellinor, Stephan B. Felix, Philippe Froguel, Christian Fuchsberger, Martin Gögele, Claus Graff, Mariaelisa Graff, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Paul L. Huang, Heikki V. Huikuri, Nina Hutri-Kähönen, M. Arfan Ikram, Rebecca D. Jackson, Juhani Junttila, Maryam Kavousi, Jan A. Kors, Thiago P. Leal, Rozenn N. Lemaitre, Henry J. Lin, Lars Lind, Allan Linneberg, Simin Liu, Peter W. MacFarlane, Massimo Mangino, Thomas Meitinger, Massimo Mezzavilla, Pashupati P. Mishra, Rebecca N. Mitchell, Nina Mononen, May E. Montasser, Alanna C. Morrison, Matthias Nauck, Victor Nauffal, Pau Navarro, Kjell Nikus, Guillaume Pare, Kristen K. Patton, Giulia Pelliccione, Alan Pittman, David J. Porteous, Peter P. Pramstaller, Michael H. Preuss, Olli T. Raitakari, Alexander P. Reiner, Antonio Luiz P. Ribeiro, Kenneth M. Rice, Lorenz Risch, David Schlessinger, Ulrich Schotten, Claudia Schurmann, Xia Shen, M. Benjamin Shoemaker, Gianfranco Sinagra, Moritz F. Sinner, Elsayed Z. Soliman, Monika Stoll, Konstantin Strauch, Kirill Tarasov, Kent D. Taylor, Andrew Tinker, Stella Trompet, André Uitterlinden, Uwe Völker, Henry Völzke, Melanie Waldenberger, Lu-Chen Weng, Eric A. Whitsel, James G. Wilson, Christy L. Avery, David Conen, Adolfo Correa, Francesco Cucca, Marcus Dörr, Sina A. Gharib, Giorgia Girotto, Niels Grarup, Caroline Hayward, Yalda Jamshidi, Marjo-Riitta Järvelin, J. Wouter Jukema, Stefan Kääb, Mika Kähönen, Jørgen K. Kanters, Charles Kooperberg, Terho Lehtimäki, Maria Fernanda Lima-Costa, Yongmei Liu, Ruth J. F. Loos, Steven A. Lubitz, Dennis O. Mook-Kanamori, Andrew P. Morris, Jeffrey R. O’Connell, Morten Salling Olesen, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Bruce M. Psaty, Jerome I. Rotter, Bruno Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James F. Wilson, Dan E. Arking, Julia Ramirez, Pier D. Lambiase, Nona Sotoodehnia, Borbala Mifsud, Christopher Newton-Cheh, Patricia B. Munroe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovasc
Externí odkaz:
https://doaj.org/article/a058778ed27d460880d80a0786a421f6
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD) outcomes. However, whether individual ceramide and sphingomyelin species
Externí odkaz:
https://doaj.org/article/54129391a2444a28a02c387c62d4d169