Zobrazeno 1 - 10
of 2 113
pro vyhledávání: '"N, Houk"'
Autor:
Sara Gutkin, Omri Shelef, Zuzana Babjaková, Laura Anna Tomanová, Matej Babjak, Tal Kopp, Qingyang Zhou, Pengchen Ma, Micha Fridman, Urs Spitz, Kendall N. Houk, Doron Shabat
Publikováno v:
JACS Au, Vol 4, Iss 9, Pp 3558-3566 (2024)
Externí odkaz:
https://doaj.org/article/8a383f951d4e41ddb8f45a28a6991b71
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Radical substitution is a useful method to functionalize heterocycles, as in the venerable Minisci reaction. Empirically observed regiochemistries indicate that the CF2H radical has a nucleophilic character similar to alkyl radicals, but the
Externí odkaz:
https://doaj.org/article/56af02b631f7408ca2251b2243d98d92
Autor:
Zexian Li, Minyan Wang, Youqing Yang, Yong Liang, Xiangyang Chen, Yue Zhao, K. N. Houk, Zhuangzhi Shi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Prized for their ability to generate chemical complexity rapidly, catalytic carbon–hydrogen (C–H) activation and functionalization reactions have enabled a paradigm shift in the standard logic of synthetic chemistry. Directing group stra
Externí odkaz:
https://doaj.org/article/644b178939ef4fd5870c2fe9079fa16a
Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp3)–H Amination
Autor:
Zi-Yang Qin, Shilong Gao, Yike Zou, Zhen Liu, James B. Wang, Kendall N. Houk, Frances H. Arnold
Publikováno v:
ACS Central Science, Vol 9, Iss 12, Pp 2333-2338 (2023)
Externí odkaz:
https://doaj.org/article/41d2f109ca4742e6878bc49881c33e10
Autor:
Rozan Tannous, Omri Shelef, Sara Gutkin, Maya David, Thomas Leirikh, Liang Ge, Qais Jaber, Qingyang Zhou, Pengchen Ma, Micha Fridman, Urs Spitz, Kendall N. Houk, Doron Shabat
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 28-42 (2023)
Externí odkaz:
https://doaj.org/article/0da49c01daf94da592702c2d9518ee08
Autor:
Sangmin Kim, Joseph W. Treacy, Yessica A. Nelson, Jordan A. M. Gonzalez, Milan Gembicky, K. N. Houk, Alexander M. Spokoyny
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Electrophilic borylation of sterically hindered arenes is a challenging transformation. Here, authors report a metal-free electrophilic C–H borylation of hindered arenes using a boron cluster reagent producing valuable aryl boronic esters.
Externí odkaz:
https://doaj.org/article/20db6fc58f9041f78d960fd9cf9b6f43
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Ligands alter the regioselectivity of Rh(I)- catalyzed cycloisomerizations of bicyclobutanes. Here, mechanistic studies performed by the authors pinpoint a concerted C−C bond cleavage and carbenoid formation responsible for the divergence.
Externí odkaz:
https://doaj.org/article/b2e7ccab14b54cda93fddef8e6875b38
Autor:
Xin Yang, Sophie Hui Min Lim, Jiachen Lin, Jie Wu, Haidi Tang, Fengyue Zhao, Fang Liu, Chenghua Sun, Xiangcheng Shi, Yulong Kuang, Joanne Yi Hui Toy, Ke Du, Yuannian Zhang, Xiang Wang, Mingtai Sun, Zhixuan Song, Tian Wang, Ji’en Wu, K. N. Houk, Dejian Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Catalysed oxidative C-C bond formation reactions are important in the synthesis of natural products, but poorly tolerated by polyphenolic flavones. Here the authors report the reactivity of molecular oxygen in alkaline water without added catalyst fo
Externí odkaz:
https://doaj.org/article/3301a34d2e2d42a28dca474d9561374a
Autor:
Lei Zhang, Chen Yang, Chenxi Lu, Xingxing Li, Yilin Guo, Jianning Zhang, Jinglong Lin, Zhizhou Li, Chuancheng Jia, Jinlong Yang, K. N. Houk, Fanyang Mo, Xuefeng Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Guiding chemical reactions in a predictable and controllable manner is an ultimate goal of chemistry. Here, the authors show tuning of the single-molecule Mizoroki-Heck catalytic cycle through electrical gating and direct in-situ detection.
Externí odkaz:
https://doaj.org/article/8e9e6b424dd4416eaea22045399bd582
Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization
Autor:
Peng Ji, Cassondra C. Davies, Feng Gao, Jing Chen, Xiang Meng, Kendall N. Houk, Shuming Chen, Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The synthesis of polycyclic structures bearing partially saturated (hetero)arenes is important as many of these structures have biological relevance. Here the authors develop a one-step method for selective dearomative functionalization of feedstock
Externí odkaz:
https://doaj.org/article/28baf2a45afa456eb5f9b2bd561f0d5d