Molecular insights into intra-complex signal transmission during stressosome activation

Autor: Algirdas Miksys, Lifei Fu, M. Gregor Madej, Duarte N. Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J. Lewis, Conor O’Byrne, Jan Pané-Farré, Christine Ziegler

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

Cryo-EM structures of the stress-sensing complex in Listeria innocua reveal conformational changes that initiate the signaling response to environmental stress.

Externí odkaz: https://doaj.org/article/faa9afa773db4d11bf6a756c291707a8

The σB-Mediated General Stress Response of Listeria monocytogenes: Life and Death Decision Making in a Pathogen

Autor: Duarte N. Guerreiro, Talia Arcari, Conor P. O’Byrne

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Sensing and responding to environmental cues is critical for the adaptability and success of the food-borne bacterial pathogen Listeria monocytogenes. A supramolecular multi-protein complex known as the stressosome, which acts as a stress sensing hub

Externí odkaz: https://doaj.org/article/ef22922c6bbe4f90879b3f06e32be334

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In Vitro Evolution of Listeria monocytogenes Reveals Selective Pressure for Loss of SigB and AgrA Function at Different Incubation Temperatures

Autor: Duarte N. Guerreiro, Jialun Wu, Emma McDermott, Dominique Garmyn, Peter Dockery, Aoife Boyd, Pascal Piveteau, Conor P. O’Byrne

Publikováno v: Applied and Environmental Microbiology
Applied and Environmental Microbiology, 2022, 88 (11), 17p. ⟨10.1128/aem.00330-22⟩
Appl Environ Microbiol

The alternative sigma factor B (σ(B)) contributes to the stress tolerance of the foodborne pathogen Listeria monocytogenes by upregulating the general stress response. We previously showed that σ(B) loss-of-function mutations arise frequently in st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eabe0d028a859b883418c16d762bc9a
https://doi.org/10.1128/aem.00330-22

Listeria monocytogenes requires the RsbX protein to prevent SigB-activation under non-stressed conditions

Autor: Hasan Tükenmez, Ana H. Oliveira, Duarte N. Guerreiro, Francisco García-del Portillo, Jörgen Johansson, Charlotte Dessaux, Teresa Tiensuu, Conor P. O'Byrne

Publikováno v: Journal of Bacteriology

The survival of microbial cells under changing environmental conditions requires an efficient reprogramming of transcription, often mediated by alternative sigma factors. The Gram-positive human pathogen Listeria monocytogenes senses and responds to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc13fd181373e6da5e8679ea407e575b
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190844