Zobrazeno 1 - 10
of 314
pro vyhledávání: '"N, Connor"'
Autor:
Zachary C. Rosenthal, Daniel M. Fass, N. Connor Payne, Angela She, Debasis Patnaik, Krista M. Hennig, Rachel Tesla, Gordon C. Werthmann, Charlotte Guhl, Surya A. Reis, Xiaoyu Wang, Yueting Chen, Michael Placzek, Noelle S. Williams, Jacob Hooker, Joachim Herz, Ralph Mazitschek, Stephen J. Haggarty
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-29 (2024)
Abstract Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN are one of the most common genetic causes of FTD, near ubiquitously resulting in pro
Externí odkaz:
https://doaj.org/article/0ce6be333ade4397a3f955c44b12062e
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103129- (2024)
Summary: Comprehensive characterization of small-molecule degraders, including binary and ternary complex formation and degradation efficiency, is critical for bifunctional ligand development and understanding structure-activity relationships. Here,
Externí odkaz:
https://doaj.org/article/df5f6971d2c24cb39eee5bdca89f796b
Autor:
Ichikawa, Saki, Payne, N. Connor, Xu, Wenqing, Chang, Chia-Fu, Vallavoju, Nandini, Frome, Spencer, Flaxman, Hope A., Mazitschek, Ralph, Woo, Christina M.
Publikováno v:
In Cell Chemical Biology 20 June 2024 31(6):1162-1175
Akademický článek
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Publikováno v:
In Free Radical Biology and Medicine 1 August 2023 204:215-225
Autor:
Keiji Kurata, Anna-James Bott, Mark A. Tye, Leona Yamamoto, Mehmet K. Samur, Yu-Tzu Tai, James Dunford, Catrine Johansson, Filiz Senbabaoglu, Martin Philpott, Charlotte Palmer, Karthik Ramasamy, Sarah Gooding, Mihaela Smilova, Giorgia Gaeta, Manman Guo, John C. Christianson, N. Connor Payne, Kritika Singh, Kubra Karagoz, Matthew E. Stokes, Maria Ortiz, Patrick Hagner, Anjan Thakurta, Adam Cribbs, Ralph Mazitschek, Teru Hideshima, Kenneth C. Anderson, Udo Oppermann
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition c
Externí odkaz:
https://doaj.org/article/9a68487f85794fbbb8d94c8c96041cdb
Autor:
Yue, Hong, Nowak, Radosław P., Overwijn, Daan, Payne, N. Connor, Fischinger, Stephanie, Atyeo, Caroline, Lam, Evan C., St. Denis, Kerri, Brais, Lauren K., Konishi, Yoshinobu, Sklavenitis-Pistofidis, Romanos, Baden, Lindsey R., Nilles, Eric J., Karlson, Elizabeth W., Yu, Xu G., Li, Jonathan Z., Woolley, Ann E., Ghobrial, Irene M., Meyerhardt, Jeffrey A., Balazs, Alejandro B., Alter, Galit, Mazitschek, Ralph, Fischer, Eric S.
Publikováno v:
In Cell Reports Methods February 2023
Autor:
Mark A. Tye, N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant, Kayla Sylvester, Madeline R. Luth, Sofia Marques, Malcolm Whitman, Maria M. Mota, Elizabeth A. Winzeler, Amanda K. Lukens, Emily R. Derbyshire, Udo Oppermann, Dyann F. Wirth, Ralph Mazitschek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and
Externí odkaz:
https://doaj.org/article/67e7e347e61b426e9ad816c4a19d8f56
Publikováno v:
In Cell Chemical Biology 18 August 2022 29(8):1333-1340
Autor:
Payne, N. Connor, Mazitschek, Ralph
Publikováno v:
In Cell Chemical Biology 21 July 2022 29(7):1140-1152