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Fluorimetric detection after liquid chromatographic separation of benzophenanthridine alkaloids obtained from cultured cells

Autor: N Chauret, J Archambault

Publikováno v: Analytica Chimica Acta. 249:231-234

The detection by fluorimetry after liquid chromatographic (LC) separation of benzophenanthridine alkaloids extracted from Papaveraceae sp. cell culture samples was characterized and optimized. Maximum fluorescence was observed at 225 nm excitation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2002de711289ec8f985a3e6bf3d91e81
https://doi.org/10.1016/0003-2670(91)87027-5

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The use of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes

Autor: N, Chauret, B, Dobbs, R L, Lackman, K, Bateman, D A, Nicoll-Griffith, D M, Stresser, J M, Ackermann, S D, Turner, V P, Miller, C L, Crespi

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(9)

Recently, a novel nonfluorescent probe 3-[2-(N,N-diethyl-N-methylammonium)-ethyl]-7-methoxy-4-methylcoumarin (AMMC), which produces a fluorescent metabolite AMHC (3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-hydroxy-4-methylcoumarin) was used with mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::774704df99b987261dcdbadd6bd67104
https://pubmed.ncbi.nlm.nih.gov/11502727

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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

Autor: J A, Yergey, L A, Trimble, J, Silva, N, Chauret, C, Li, M, Therien, E, Grimm, D A, Nicoll-Griffith

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(5)

The metabolic profile of DFU [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone], a potent and selective COX-2 inhibitor, was characterized using in vitro microsomal and hepatocyte incubations. A single product, corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae02be5946192129642e9eb96f499a7
https://pubmed.ncbi.nlm.nih.gov/11302928

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Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Autor: C, Li, N, Chauret, L A, Trimble, D A, Nicoll-Griffith, J M, Silva, D, MacDonald, H, Perrier, J A, Yergey, T, Parton, R P, Alexander, G J, Warrellow

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(3)

CDP-840 is a selective and potent phosphodiesterase type IV inhibitor, whose in vitro metabolism profile was first investigated using liver microsomes from different species. At least 10 phase I oxidative metabolites (M1-M10) were detected in the mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::458706185182beeba237821b1ff18b78
https://pubmed.ncbi.nlm.nih.gov/11181489

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Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor

Autor: D A, Nicoll-Griffith, J M, Silva, N, Chauret, S, Day, Y, Leblanc, P, Roy, J A, Yergey, R, Dixit, D, Patrick

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(2)

The drug candidate DFP [5,5-dimethyl-3-(2-isopropoxy)-4-(4-methanesulfonylphenyl)-2(5H)-furanone] is a selective cyclooxygenase-2 inhibitor under evaluation for analgesic and anti-inflammatory therapy. The in vitro metabolic pathways (rat microsomes)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a99b6f7881f73e5c08abc47b1d1b8acf
https://pubmed.ncbi.nlm.nih.gov/11159806

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