Zobrazeno 1 - 10
of 780
pro vyhledávání: '"N, Bodor"'
Publikováno v:
Bulletin of Pharmaceutical Sciences. Assiut. 21:41-54
Certain new monoamine oxidase inhibitors (MAOIs) containing a pyridinium moiety as an integral part of their structures (Q) were designed. The quaternaries, their corresponding 1,4-dihydroxypyridine derivatives (CDS) and their parent pyridine compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78014aaa6df6fe9f76a53df113b6fb3f
https://doi.org/10.21608/bfsa.1998.67834
https://doi.org/10.21608/bfsa.1998.67834
Autor:
Alistair I. Webb, E. Pop, M. E. Brewster, Hartmut Derendorf, D Moreno, L M Pablo, D Meinsma, W. R. Anderson, N Bodor
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:122-128
AIDS encephalopathy is an insidious complication of human immunodeficiency virus infection which is difficult to treat because of the poor uptake of many potentially useful antiretroviral drugs through the blood-brain barrier. A chemical delivery sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8becdf9663508e9748ebf2cf5f4b0d
https://doi.org/10.1128/aac.41.1.122
https://doi.org/10.1128/aac.41.1.122
Publikováno v:
Pharmaceutical research. 1(3)
The "inactive metabolite approach" was used to design β-blockers. The acidic inactive metabolite of metoprolol [4-(2-hydroxy-3-isopropylamino) propoxyphenylacetic acid] was used as the lead compound. Its esters (alkyl and cycloalkyl) were found acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b005935176579fe1e1d3364a3f72f5b5
https://pubmed.ncbi.nlm.nih.gov/24277248
https://pubmed.ncbi.nlm.nih.gov/24277248
Publikováno v:
Pharmaceutical research. 1(4)
O,O-Di(ethylsuccinyl) adrenalone was synthesized and studied as a potential short-acting mydriatic agent. This unsymmetrical tetraester has a very short hydrolytic half-life in biological fluids (approximately 1 minute). The hydrolysis produces the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14edfb16c64941783155acc19df2d9b5
https://pubmed.ncbi.nlm.nih.gov/24277286
https://pubmed.ncbi.nlm.nih.gov/24277286
Publikováno v:
Pharmaceutical research. 3(5)
Dihydropyridine ⇄ pyridinium salt-based brain-selective delivery systems were synthesized for the progestins, ethisterone, norethindrone, and norgestrel. After initial lipophilicity and in vitro studies indicated the feasibility of applying these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55ce4ef52db086e895caae8febf37576
https://pubmed.ncbi.nlm.nih.gov/24271710
https://pubmed.ncbi.nlm.nih.gov/24271710
Publikováno v:
Die Pharmazie. 67(5)
The effect of delta1-cortienic acid (delta1-CA) on human skin blanching activity of the soft corticosteroid, loteprednol etabonate (LE), has been studied. Ten volunteers had applied to their forearms a dose of LE ranging from 0.1 to 1 mM, or LE from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf107cf0a28d19623ede90093594ade3
https://pubmed.ncbi.nlm.nih.gov/22764572
https://pubmed.ncbi.nlm.nih.gov/22764572
Publikováno v:
Advanced Drug Delivery Reviews. 14:167-175
While estrogens readily penetrate the blood-brain barrier and exert significant CNS effects, they are not retained by this organ, obligating constant dosing to achieve sustained and pharmacologically relevant brain concentrations. Such a regimen also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d462f1731d02d687487536a09ccbc3
https://doi.org/10.1016/0169-409x(94)90037-x
https://doi.org/10.1016/0169-409x(94)90037-x
Autor:
M.E. Brewster, N. Bodor
Publikováno v:
Advanced Drug Delivery Reviews. 14:177-197
The inability to effectively deliver antiviral agents to the brain and central nervous system can be overcome via drug latentiation and, specifically, via a redox chemical delivery system. This approach has been successfully applied to a variety of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb94f634967b925f917e607078bf628
https://doi.org/10.1016/0169-409x(94)90038-8
https://doi.org/10.1016/0169-409x(94)90038-8
Autor:
N. Bodor
Publikováno v:
Advanced Drug Delivery Reviews. 14:157-166
Traditional methods for drug design have relied on optimization of drug activity with little regard for drug safety. Such manipulation often produces highly potent derivatives with equally elevated toxicities giving rise to no or disadvantageous chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83c441f18fb6d27b3f7bb680cf0f0b8b
https://doi.org/10.1016/0169-409x(94)90036-1
https://doi.org/10.1016/0169-409x(94)90036-1
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:817-823
Enhanced delivery of ganciclovir to the brain was demonstrated by a redox-based chemical delivery system. A ganciclovir monoester in which a 1-methyl-1,4-dihydronicotinate was covalently attached to one of the hydroxymethyl functions was prepared. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8409252f3deb487bd2971e3f3e95e7d
https://doi.org/10.1128/aac.38.4.817
https://doi.org/10.1128/aac.38.4.817