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Akademický článek

Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry

Autor: G. Rouby, N. T. Tran, Y. Leblanc, M. Taverna, N. Bihoreau

Publikováno v: mAbs, Vol 12, Iss 1 (2020)

Therapeutic monoclonal antibodies (mAbs) are highly complex proteins that must be exhaustively characterized according to the regulatory authorities' recommendations. MAbs display micro-heterogeneity mainly due to their post-translational modificatio

Externí odkaz: https://doaj.org/article/dbd6707f7d604439a51f703590da1b35

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Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry

Autor: N Bihoreau, Nguyet Thuy Tran, G Rouby, Myriam Taverna, Y Leblanc

Publikováno v: mAbs
article-version (VoR) Version of Record

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee90acde2c464a8c4d4707b22ee10f
https://doi.org/10.1080/19420862.2020.1781743

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Differential investigations from plasma-derived and recombinant Factor IX revealed major differences in post-translational modifications of activation peptides

Autor: G, Chevreux, V, Faid, M-H, Andre, Z, Tellier, N, Bihoreau

Publikováno v: Vox sanguinis. 104(2)

Post-translational modifications (PTMs) located on the activation peptide (AP) of recombinant FIX (rFIX, BeneFIX(®) ) and plasma-derived FIX (pdFIX, Betafact(®) ) have been investigated by mass spectrometry to review the structural differences betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25cee91ee995bde60c2efeb3a092509c
https://pubmed.ncbi.nlm.nih.gov/22958127

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Evidence that a secondary binding and protecting site for factor VIII on von Willebrand factor is highly unlikely

Autor: Jean-Pierre Girma, E Peynaud-Debayle, Bernadette Obert, S Layet, N Bihoreau, Dominique Meyer

Publikováno v: Biochemical Journal. 282:129-137

A binding domain for Factor VIII (F.VIII) has been previously identified on the N-terminal portion of human von Willebrand Factor (vWF) subunit [amino acids (AA) 1-272]. In order to characterize other possible structures of vWF involved in its capaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9433eb55733744cd4adf4e79dd6ec5c9
https://doi.org/10.1042/bj2820129

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Combination of capillary electrophoresis and matrix-assisted laser desorption ionization mass spectrometry for glycosylation analysis of a human monoclonal anti-Rhesus(D) antibody

Autor: N. Bihoreau, J.M. Schmitter, M. Lazard, C. Ramon

Publikováno v: Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 1997, 697 (41306), pp.123. ⟨10.1016/S0378-4347(97)00305-8⟩

International audience; Characterization of a human anti-Rhesus(D) monoclonal antibody, developed for the treatment of Rh(D) haemolytic disease of the newborn, was performed, Capillary electrophoresis (CE) has been employed for peptide mapping of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1baa40dd1dc3a3ebf295948fbf5912
https://hal-polytechnique.archives-ouvertes.fr/hal-00788519

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Metal identification in human anti-hemophilia A factor (factor VIII)

Autor: N, Bihoreau, S, Pin, A M, de Kersabiec, F, Vidot, M P, Fontaine-Aupart

Publikováno v: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 316(5)

Anti-hemophilia A factor (FVIII) consists in different heterodimers of heavy and light chains associated by a metallic ion. The integrity of this complex is indispensable for procoagulant activity. Atomic absorption spectrometry with Zeeman effect ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3622806b099253d8528dec23b67afabe
https://pubmed.ncbi.nlm.nih.gov/8221239

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PRODUCTION AND CHARACTERIZATION OF A RECOMBINANT FACTOR VIII EXPRESSED BY CHO CELLS CULTURED IN SERUM SUPPLEMENTED OR IN SERUM FREE MEDIA

Autor: P. Paolantonacci, J.L. Romet-Lemonne, V. Toully, G. Mignot, A. Sauger, N. Bihoreau

A variant of factor VIII, FVIII-δII (Meulien et al. , 1988) is a new candidate for the treatment of hemophilia A. It is produced by CHO cells with a better yield of expression than complete FVIII and exhibits in vitro and in vivo coagulant activitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d629aeb6734f9066755734fa48a9465
https://doi.org/10.1016/b978-0-7506-0421-5.50044-1

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A solvent/detergent-treated and 15-nm filtered factor VIII: a new safety standard for plasma-derived coagulation factor concentrates

Autor: S. Chtourou, S. Raut, E. Cheesman, P. Porte, N. Bihoreau, Bruno Samor, M. Nogré, A. Sauger, Claudine Mazurier

Publikováno v: Vox Sanguinis. :070315094549001

Background Since the early 1990s the Committee for Proprietary Medicinal Products has set the mandatory requirement that all manufacturing processes for blood products include two virus removal/inactivation steps that are complementary in their actio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7681fb21274f5b4673d12eb00102b2e4
https://doi.org/10.1111/j.1423-0410.2007.00892.x

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Akademický článek

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