Zobrazeno 1 - 10
of 75
pro vyhledávání: '"N, Bernad"'
Autor:
B. G. M. Burgaud, Jean Martinez, N. Bernad, David Christopher Horwell, R. A. Lewthwaite, Martyn Clive Pritchard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1245-1248
The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the str
Publikováno v:
Tetrahedron: Asymmetry. 6:1081-1084
The asymmetric synthesis, CCK receptor binding affinities and CCK-A agonist properties of a novel series of non-peptide CCK-A receptor selective ligands is reported.
Publikováno v:
ChemInform. 26
The asymmetric synthesis, CCK receptor binding affinities and CCK-A agonist properties of a novel series of non-peptide CCK-A receptor selective ligands is reported.
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 226:35-41
Preliminary studies on CCK receptors in the central nervous system were carried out on guinea pig cerebral cortical synaptoneurosome preparations. In binding assays, the range of affinity of CCK-8, Boc-[Nle28, Nle31]CCK-7, a potent CCK analog, Boc-[L
Autor:
Jean Martinez, André Aumelas, Marc Rodriguez, M F Lignon, N Bernad, Jeanine Laur, Marie-Christine Galas
Publikováno v:
European Journal of Medicinal Chemistry. 26:245-253
Acetyl derivatives of ethyl esters of 3-(1-naphthyl)- d,l -alanine and 3-(2-naphthyl)- d,l -alanine were synthesized through a malonic condensation. Resolution of these derivatives by subtilisin Carlsberg followed by acid hydrolysis afforded the 2 op
Autor:
B. G. M. Burgaud, Martyn Clive Pritchard, R. A. Lewthwaite, Jean Martinez, N. Bernad, David Christopher Horwell
Publikováno v:
ChemInform. 31
The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the str
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 5(4)
Bombesin pseudo-peptide analogues containing a hydroxamide function on the C-terminal part of the molecule, e.g. H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOBzl 1 and H-D-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-NHOH 2 were synthesized. These compounds were tested
Autor:
M, Llinares, C, Devin, O, Chaloin, J, Azay, A M, Noel-Artis, N, Bernad, J A, Fehrentz, J, Martinez
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 53(3)
Bombesin receptor antagonists are potential therapeutic agents due to their ability to act as inhibitors of cellular proliferation. On the basis of our hypothesis concerning the mechanism of action of gastrin associating an activating enzyme to the r
Autor:
Patrick Eldin, M F Lignon, Catherine Oiry, Gilbert Bergé, D. Gagne, Martine Le Cunff, Éric Cottin, Jean Martinez, N Bernad, J. C. Galleyrand, Pascal Clerc, Daniel Fourmy, Jean J. Leger
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1997, 52 (2), pp.292-299. ⟨10.1124/mol.52.2.292⟩
ResearcherID
Scopus-Elsevier
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 1997, 52 (2), pp.292-299. ⟨10.1124/mol.52.2.292⟩
ResearcherID
Scopus-Elsevier
The aim of this study was to analyze the role of cholecystokinin (CCK(B)) receptor in human lymphoblastic Jurkat T cells. We investigated the trophic effect resulting from activation of such a receptor by using the reporter gene strategy. For this pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0464e1be619d08075c2a7d210366f34
https://hal.archives-ouvertes.fr/hal-02438927
https://hal.archives-ouvertes.fr/hal-02438927
Publikováno v:
Biopolymers. 36(4)
The sequence of a cholecystokinin (CCK) related peptide was modified to obtain analogues, which interact selectively either with CCK-B, or with delta-opioid receptors. Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cycl