Evaluating Molecular Mechanism of Viral Inhibition of Aerosolized Smart Nano-Enabled Antiviral Therapeutic (SNAT) on SARS-CoV-2-Infected Hamsters

Autor: Anais N. Bauer, John F. Williams, Lok R. Pokhrel, Selena Garcia, Niska Majumdar, Jeffrey B. Eells, Paul P. Cook, Shaw M. Akula

Publikováno v: Toxics, Vol 12, Iss 7, p 495 (2024)

Smart Nano-enabled Antiviral Therapeutic (SNAT) is a promising nanodrug that previously demonstrated efficacy in preclinical studies to alleviate SARS-CoV-2 pathology in hamsters. SNAT comprises taxoid (Tx)-decorated amino (NH2)-functionalized near-a

Externí odkaz: https://doaj.org/article/c47b1d18a2a84e449a24de4c0ccf75b1

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling

Autor: Jason A. Hackney, Haridha Shivram, Jason Vander Heiden, Chris Overall, Luz Orozco, Xia Gao, Eugene Kim, Nathan West, Aditi Qamra, Diana Chang, Arindam Chakrabarti, David F. Choy, Alexis J. Combes, Tristan Courau, Gabriela K. Fragiadakis, Arjun Arkal Rao, Arja Ray, Jessica Tsui, Kenneth Hu, Nicholas F. Kuhn, Matthew F. Krummel, David J. Erle, Kirsten Kangelaris, Aartik Sarma, Zoe Lyon, Carolyn S. Calfee, Prescott G. Woodruff, Rajani Ghale, Eran Mick, Ashley Byrne, Beth Shoshana Zha, Charles Langelier, Carolyn M. Hendrickson, Monique G.P. van der Wijst, George C. Hartoularos, Tianna Grant, Raymund Bueno, David S. Lee, John R. Greenland, Yang Sun, Richard Perez, Anton Ogorodnikov, Alyssa Ward, Chun Jimmie Ye, Thiru Ramalingam, Jacqueline M. McBride, Fang Cai, Anastasia Teterina, Min Bao, Larry Tsai, Ivan O. Rosas, Aviv Regev, Sharookh B. Kapadia, Rebecca N. Bauer, Carrie M. Rosenberger, Yumiko Abe-Jones, Michael Adkisson, K. Mark Ansel, Saurabh Asthana, Alexander Beagle, Sharvari Bhide, Cathy Cai, Saharai Caldera, Maria Calvo, Sidney A. Carrillo, Suzanna Chak, Stephanie Christenson, Zachary Collins, Spyros Darmanis, Angela Detweiler, Catherine DeVoe, Walter Eckalbar, Jeremy Giberson, Ana Gonzalez, Gracie Gordon, Paula Hayakawa Serpa, Alejandra Jauregui, Chayse Jones, Serena Ke, Divya Kushnoor, Tasha Lea, Deanna Lee, Aleksandra Leligdowicz, Yale Liu, Salman Mahboob, Lenka Maliskova, Michael Matthay, Elizabeth McCarthy, Priscila Muñoz-Sandoval, Norma Neff, Viet Nguyen, Nishita Nigam, Randy Parada, Maira Phelps, Logan Pierce, Priya Prasad, Sadeed Rashid, Gabriella Reeder, Nicklaus Rodriguez, Bushra Samad, Andrew Schroeder, Cole Shaw, Alan Shen, Austin Sigman, Pratik Sinha, Matthew Spitzer, Sara Sunshine, Kevin Tang, Luz Torres Altamirano, Alexandra Tsitsiklis, Erden Tumurbaatar, Vaibhav Upadhyay, Alexander Whatley, Andrew Willmore, Michael Wilson, Juliane Winkler, Kristine Wong, Kimberly Yee, Michelle Yu, Mingyue Zhou, Wandi S. Zhu

Publikováno v: iScience, Vol 26, Iss 10, Pp 107813- (2023)

Summary: Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes across

Externí odkaz: https://doaj.org/article/9fcf76e7c2d9439cbd17b0a0b7fa8d89

Integrated systems modeling of severe asthma: Exploration of IL‐33/ST2 antagonism

Autor: Kapil Gadkar, Justin Feigelman, Siddharth Sukumaran, Manoj C. Rodrigo, Tracy Staton, Fang Cai, Rebecca N. Bauer, David F. Choy, Cynthia L. Stokes, Heleen Scheerens, Saroja Ramanujan

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1268-1277 (2022)

Abstract Asthma is a complex, heterogeneous disease with a high unmet medical need, despite therapies targeting a multitude of pathways. The ability to quantitatively integrate preclinical and clinical data on these pathways could aid in the developm

Externí odkaz: https://doaj.org/article/d4c73fd7fc9c4dc591d8ab594626b323

REMIND2.1: transformation and innovation dynamics of the energy-economic system within climate and sustainability limits

Autor: L. Baumstark, N. Bauer, F. Benke, C. Bertram, S. Bi, C. C. Gong, J. P. Dietrich, A. Dirnaichner, A. Giannousakis, J. Hilaire, D. Klein, J. Koch, M. Leimbach, A. Levesque, S. Madeddu, A. Malik, A. Merfort, L. Merfort, A. Odenweller, M. Pehl, R. C. Pietzcker, F. Piontek, S. Rauner, R. Rodrigues, M. Rottoli, F. Schreyer, A. Schultes, B. Soergel, D. Soergel, J. Strefler, F. Ueckerdt, E. Kriegler, G. Luderer

Publikováno v: Geoscientific Model Development, Vol 14, Pp 6571-6603 (2021)

This paper presents the new and now open-source version 2.1 of the REgional Model of INvestments and Development (REMIND). REMIND, as an integrated assessment model (IAM), provides an integrated view of the global energy–economy–emissions system

Externí odkaz: https://doaj.org/article/873cfed5be1442eb88cbb294386d10d3

Tocilizumab in patients hospitalised with COVID-19 pneumonia: Efficacy, safety, viral clearance, and antibody response from a randomised controlled trial (COVACTA)

Autor: Ivan O. Rosas, Norbert Bräu, Michael Waters, Ronaldo C. Go, Atul Malhotra, Bradley D. Hunter, Sanjay Bhagani, Daniel Skiest, Sinisa Savic, Ivor S. Douglas, Julia Garcia-Diaz, Mariam S. Aziz, Nichola Cooper, Taryn Youngstein, Lorenzo Del Sorbo, David J. De La Zerda, Andrew Ustianowski, Antonio Cubillo Gracian, Kevin G. Blyth, Jordi Carratalà, Bruno François, Thomas Benfield, Derrick Haslem, Paolo Bonfanti, Cor H. van der Leest, Nidhi Rohatgi, Lothar Wiese, Charles Edouard Luyt, Rebecca N. Bauer, Fang Cai, Ivan T. Lee, Balpreet Matharu, Louis Metcalf, Steffen Wildum, Emily Graham, Larry Tsai, Min Bao

Publikováno v: EClinicalMedicine, Vol 47, Iss , Pp 101409- (2022)

Summary: Background: In COVACTA, a randomised, placebo-controlled trial in patients hospitalised with coronavirus disease-19 (COVID-19), tocilizumab did not improve 28-day mortality, but shortened hospital and intensive care unit stay. Longer-term ef

Externí odkaz: https://doaj.org/article/0cce1eb2d409455cafdb2877f5cbfad7