Zobrazeno 1 - 10
of 149
pro vyhledávání: '"N, Antonescu"'
Autor:
Timothy J Walker, Eduardo Reyes-Alvarez, Brandy D Hyndman, Michael G Sugiyama, Larissa CB Oliveira, Aisha N Rekab, Mathieu JF Crupi, Rebecca Cabral-Dias, Qianjin Guo, Patricia LM Dahia, Douglas S Richardson, Costin N Antonescu, Lois M Mulligan
Publikováno v:
eLife, Vol 12 (2024)
Internalization from the cell membrane and endosomal trafficking of receptor tyrosine kinases (RTKs) are important regulators of signaling in normal cells that can frequently be disrupted in cancer. The adrenal tumor pheochromocytoma (PCC) can be cau
Externí odkaz:
https://doaj.org/article/56671c5952a34e068944e75893122071
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105883- (2023)
Summary: Ultrasound-stimulated microbubble (USMB) treatment is a promising strategy for cancer therapy. USMB promotes drug delivery by sonoporation and enhanced endocytosis, and also impairs cell viability. However, USMB elicits heterogeneous effects
Externí odkaz:
https://doaj.org/article/99b6f6c8cfa5494fbaea15f56939ff51
Autor:
Michael G. Sugiyama, Haotian Cui, Dar’ya S. Redka, Mehran Karimzadeh, Edurne Rujas, Hassaan Maan, Sikander Hayat, Kyle Cheung, Rahul Misra, Joseph B. McPhee, Russell D. Viirre, Andrew Haller, Roberto J. Botelho, Raffi Karshafian, Sarah A. Sabatinos, Gregory D. Fairn, Seyed Ali Madani Tonekaboni, Andreas Windemuth, Jean-Philippe Julien, Vijay Shahani, Stephen S. MacKinnon, Bo Wang, Costin N. Antonescu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The COVID-19 pandemic has highlighted the urgent need for the identification of new antiviral drug therapies for a variety of diseases. COVID-19 is caused by infection with the human coronavirus SARS-CoV-2, while other related human coronavi
Externí odkaz:
https://doaj.org/article/6fc7b459daf94a499be2325b0bbff79f
Publikováno v:
Energies, Vol 15, Iss 24, p 9373 (2022)
Following the international trend of using hydrogen as combustible in many industry branches, this paper investigates the impact of mixing methane gas with 23% hydrogen (G222) on condensing boilers’ operation. After modeling and testing several boi
Externí odkaz:
https://doaj.org/article/faa6112f576d4965b9881d35189ac1cf
Autor:
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic pain has been widely recognized as a major public health problem that impacts multiple aspects of patient quality of life. Unfortunately, chronic pain is often resistant to conventional analgesics, which are further limited by their various s
Externí odkaz:
https://doaj.org/article/30cb61b8aa824cab8b21e0995f05f8e9
Autor:
Oana N Antonescu, Andreas Rasmussen, Nicole A M Damm, Ditte F Heidemann, Roman Popov, Alexander Nesterov-Mueller, Kristoffer E Johansson, Jakob R Winther
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0241461 (2021)
Split fluorescent proteins have wide applicability as biosensors for protein-protein interactions, genetically encoded tags for protein detection and localization, as well as fusion partners in super-resolution microscopy. We have here established an
Externí odkaz:
https://doaj.org/article/84725b04e0e34171a4a96c9d7a797c06
Publikováno v:
Applied Sciences, Vol 12, Iss 8, p 3831 (2022)
Considering the imperative reduction in CO2 emissions, both from household heating and hot water producing facilities, one of the mainstream directions is to reduce hydrocarbons in combustibles by replacing them with hydrogen. The authors analyze con
Externí odkaz:
https://doaj.org/article/6b94427fb34a45abb5905aba565f4e49
Autor:
Costin N. Antonescu, Allen P. Liu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Externí odkaz:
https://doaj.org/article/e7cac4c6435440a2b9cb2402695e6260
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions, including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine kinases are critical regulators of Akt, as a result of activation of p
Externí odkaz:
https://doaj.org/article/400e9b3690f542debc34246351069bce