Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mzwanele Ngubo"'
Publikováno v:
Genes, Vol 14, Iss 10, p 1879 (2023)
The Polycomb repressive complex 2 (PRC2) is a conserved chromatin-remodelling complex that catalyses the trimethylation of histone H3 lysine 27 (H3K27me3), a mark associated with gene silencing. PRC2 regulates chromatin structure and gene expression
Externí odkaz:
https://doaj.org/article/963f00c487324f4d8eabeca444115251
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268760 (2022)
We have performed a comprehensive analysis of the involvement of histone H3 and H4 residues in the regulation of chronological lifespan in yeast and identify four structural groups in the nucleosome that influence lifespan. We also identify residues
Externí odkaz:
https://doaj.org/article/fea4c60c8ab0425f9c387da5f10506e1
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
INO80 chromatin remodeler plays important roles in transcription, DNA repair, recombination, and heterochromatin maintenance. Here the authors characterise the functional interplay between the actin-related proteins (Arps) in INO80, showing that Arp8
Externí odkaz:
https://doaj.org/article/e00fc131e6374772ad0cb36e70283b47
Autor:
Mzwanele Ngubo
Publikováno v:
The Nucleus. 64:277-284
During aging, cells are continuously exposed to a range of environmental and endogenous conditions causing DNA damage, genomic instability and cellular stresses. At the DNA damage sites, essential biological processes such as transcription and replic
Publikováno v:
PloS one. 17(5)
We have performed a comprehensive analysis of the involvement of histone H3 and H4 residues in the regulation of chronological lifespan in yeast and identify four structural groups in the nucleosome that influence lifespan. We also identify residues
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
Nuclear actin and actin-related proteins (Arps) are key components of chromatin remodeling and modifying complexes. Although Arps are essential for the functions of chromatin remodelers, their specific roles and mechanisms are unclear. Here we define
Publikováno v:
BMC Biochemistry
BMC Biochemistry, Vol 12, Iss 1, p 34 (2011)
BMC Biochemistry, Vol 12, Iss 1, p 34 (2011)
Background The involvement of histone acetylation in facilitating gene expression is well-established, particularly in the case of histones H3 and H4. It was previously shown in Saccharomyces cerevisiae that gene expression was significantly down-reg