Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Myunggon, Ko"'
Publikováno v:
Materials Today Bio, Vol 27, Iss , Pp 101123- (2024)
Ten-eleven translocation (TET) proteins orchestrate deoxyribonucleic acid (DNA) methylation-demethylation dynamics by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and are frequently inactivated in various cancers. Due to the significa
Externí odkaz:
https://doaj.org/article/41a66c9bbcb5455c82e326a70dfd5644
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 654 (2023)
Epigenetic modifications are crucial regulators of gene expression that critically impact cell lineage differentiation, survival, and proliferation, and dysregulations are commonly observed in various cancers. The aberrantly modified epigenome confer
Externí odkaz:
https://doaj.org/article/dc5a314507c8470a9b39a80fa354c28c
Autor:
Sara Montagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccolo, Susan Togher, Myunggon Ko, Anjana Rao, Gioacchino Natoli, Silvia Monticelli
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1566-1579 (2016)
Summary: Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation. In the abse
Externí odkaz:
https://doaj.org/article/40b26c13096e42519aa36b21a13ac9d2
Autor:
Jinguk Jeong, Inkyung Jung, Ji-Hoon Kim, Shin Jeon, Do Young Hyeon, Hyungyu Min, Byeonggeun Kang, Jinwoo Nah, Daehee Hwang, Soo-Jong Um, Myunggon Ko, Rho Hyun Seong
Publikováno v:
Cell Death & Differentiation. 29:2151-2162
Hematopoiesis occurs within a unique bone marrow (BM) microenvironment, which consists of various niche cells, cytokines, growth factors, and extracellular matrix components. These multiple components directly or indirectly regulate the maintenance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfb16185798549057e94c0a235230ae
https://doi.org/10.1038/s41418-022-01006-y
https://doi.org/10.1038/s41418-022-01006-y
Autor:
Hiroshi Yuita, Isaac F. López-Moyado, Hyeongmin Jeong, Arthur Xiuyuan Cheng, James Scott-Browne, Jungeun An, Toshinori Nakayama, Atsushi Onodera, Myunggon Ko, Anjana Rao
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of DNA demethylation. To define the in vivo consequences of complete TET defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92cdf558994544c06a8156f7f4b806ab
https://doi.org/10.1073/pnas.2214824120
https://doi.org/10.1073/pnas.2214824120
Autor:
Habibulla Imran, Jungeun An, Kyumin Jang, Asrar Alam, Venkataraman Dharuman, Myunggon Ko, Sooman Lim
Publikováno v:
Journal of Alloys and Compounds. 948:169715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::233672ab7689b432af930188a5681774
https://doi.org/10.1016/j.jallcom.2023.169715
https://doi.org/10.1016/j.jallcom.2023.169715
Autor:
Seongjun Byun, Chan Hyeong Lee, Hyeongmin Jeong, Hyejin Kim, Hyug Moo Kwon, Sungho Park, Kyungjae Myung, Jungeun An, Myunggon Ko
Publikováno v:
Proceedings of the National Academy of Sciences. 119
β-adrenergic receptor (β-AR) signaling plays predominant roles in modulating energy expenditure by triggering lipolysis and thermogenesis in adipose tissue, thereby conferring obesity resistance. Obesity is associated with diminished β3-adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d16a4788c72a10f45fcb4e9ace78117
https://doi.org/10.1073/pnas.2205626119
https://doi.org/10.1073/pnas.2205626119
Publikováno v:
Talanta. 244
5-hydroxymethylcytosine (5hmC) is a key epigenetic mark in the mammalian genome that has been proposed as a promising cancer biomarker with diagnostic and prognostic potentials. A new type of two-dimensional (2D) material called MXene includes transi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db0b3d28925bf455d90e14fcff375efc
https://pubmed.ncbi.nlm.nih.gov/35397322
https://pubmed.ncbi.nlm.nih.gov/35397322
Autor:
Jungeun An, Myunggon Ko
Publikováno v:
International Journal of Molecular Sciences. 24:1727
The mammalian DNA methylation landscape is established and maintained by the combined activities of the two key epigenetic modifiers, DNA methyltransferases (DNMT) and Ten-eleven-translocation (TET) enzymes. Once DNMTs produce 5-methylcytosine (5mC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d36f1421dfb71635e97d9ff37746cc4c
https://doi.org/10.3390/ijms24021727
https://doi.org/10.3390/ijms24021727
Autor:
Sara Montagner, Cristina Leoni, Stefan Emming, Giulia Della Chiara, Chiara Balestrieri, Iros Barozzi, Viviana Piccolo, Susan Togher, Myunggon Ko, Anjana Rao, Gioacchino Natoli, Silvia Monticelli
Publikováno v:
Cell Reports, Vol 20, Iss 7, p 1744 (2017)
Externí odkaz:
https://doaj.org/article/facce51c002d4c5c9b88a837aba8c205