Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Myung Jin Son"'
Autor:
Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Jaeseo Lee, Hyun-Soo Cho, Dae-Soo Kim, Kyung-Sook Chung, Myung Jin Son
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Genetic liver disease modeling is difficult because it is challenging to access patient tissue samples and to develop practical and relevant model systems. Previously, we developed novel proliferative and functional liver organoids from plur
Externí odkaz:
https://doaj.org/article/642e2912486f4595a8dd329a309d912c
Autor:
Seo Yoon Choi, Tae Hee Kim, Min Jeong Kim, Seon Ju Mun, Tae Sung Kim, Ki Kyung Jung, Il Ung Oh, Jae Ho Oh, Myung Jin Son, Jin Hee Lee
Publikováno v:
Toxics, Vol 12, Iss 5, p 371 (2024)
“Organoids”, three-dimensional self-organized organ-like miniature tissues, are proposed as intermediary models that bridge the gap between animal and human studies in drug development. Despite recent advancements in organoid model development, s
Externí odkaz:
https://doaj.org/article/0b786a53de2f47699299e05026f37a13
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107675- (2023)
Summary: To gain deeper insights into transcriptomes and epigenomes of organoids, liver organoids from two states (expandable and more differentiated) were subjected to single-cell RNA-seq (scRNA-seq) and single-cell ATAC-seq (scATAC-seq) analyses. M
Externí odkaz:
https://doaj.org/article/2fd0660c7a624aacaca84486a2a77750
Autor:
Hyo-Suk Ahn, Jae-Sung Ryu, Jaeseo Lee, Seon Ju Mun, Yeon-Hwa Hong, Yongbo Shin, Kyung-Sook Chung, Myung Jin Son
Publikováno v:
Cell Journal, Vol 24, Iss 3, Pp 133-139 (2022)
Objective: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare type of primary liver cancer with characteristics of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). The pathogenesis of cHCCCC is poorly understood due to a
Externí odkaz:
https://doaj.org/article/00d53389845544ad870ed67297f606df
Publikováno v:
Organoid, Vol 2 (2022)
The liver is the most important metabolic organ in the body. Model systems that recapitulate the complex organ structure and cell composition of the human liver are insufficient to study liver biology and to test toxicity and efficacy during new drug
Externí odkaz:
https://doaj.org/article/e756ca695bdb409db960d4f6eed9862c
Publikováno v:
Organoid, Vol 2 (2022)
Drug safety issues continue to occur even with drugs that are approved after the completion of clinical studies. Drug-induced liver injury (DILI) is a major obstacle to drug development, because the liver is the primary site of drug metabolism, and i
Externí odkaz:
https://doaj.org/article/f0334943d30d48949cc09bcf767daa99
Publikováno v:
Organoid, Vol 2 (2022)
Background Mature liver organoids are potential cellular sources for research to understand the pathology of several liver-related conditions, including end-stage chronic liver disease. Although several methods exist for the differentiation of mature
Externí odkaz:
https://doaj.org/article/6db76bf32b5746d3b19e511673fd13e6
Autor:
Yongbo Shin, Seon Ju Mun, Jaeseo Lee, Kyung-Sook Chung, Misuk Kim, Chong Kun Cheon, Myung Jin Son
Publikováno v:
Stem Cell Research, Vol 57, Iss , Pp 102584- (2021)
Glycogen storage disease type IXa (GSD IXa) is a rare genetic disorder characterized by phosphorylase kinase (PhK) deficiency, which leads to excessive glycogen accumulation in the liver. Urinary cells (UCs) were isolated from a GSD IXa patient and r
Externí odkaz:
https://doaj.org/article/65004ed9fae84708a42b793961f434a6
Autor:
Jae-Sung Ryu, Minji Lee, Seon Ju Mun, Sin-Hyoung Hong, Ho-Joon Lee, Hyo-Suk Ahn, Kyung-Sook Chung, Gun-Hwa Kim, Myung Jin Son
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-14 (2019)
Abstract Background Non-alcoholic fatty liver disease (NAFLD) begins as simple hepatic steatosis, but further progress to chronic liver diseases results in severe liver damage and hepatic failure. However, therapeutic options are scarce due to the la
Externí odkaz:
https://doaj.org/article/3d58a831023f4eab8b34b3c9afbe2770
Autor:
Myung Jin Son, Jae Kap Jeong, Youjeong Kwon, Jae-Sung Ryu, Seon Ju Mun, Hye Jin Kim, Sung-wuk Kim, Sanghee Yoo, Jiae Kook, Hongbum Lee, Janghwan Kim, Kyung-Sook Chung
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-15 (2018)
Stem cells: A remedy to revitalize the roots A compound that establishes metabolic conditions favorable for sustaining stem cells may also offer a safe drug for promoting hair regrowth. Drugs that inhibit mitochondrial activity help lock stem cells i
Externí odkaz:
https://doaj.org/article/af78d44cff2940358f43e469203c4b43