Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Myung Chang Lee"'
Autor:
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M.E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111990- (2023)
Summary: Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate r
Externí odkaz:
https://doaj.org/article/0a467d5273d64bf6976383eac519d5b0
Autor:
Alex Doan, Julia Arand, Diana Gong, Alexandros P. Drainas, Yan Ting Shue, Myung Chang Lee, Shuyuan Zhang, David M. Walter, Andrea C. Chaikovsky, David M. Feldser, Hannes Vogel, Lukas E. Dow, Jan M. Skotheim, Julien Sage
Publikováno v:
PLoS Genetics, Vol 17, Iss 12 (2021)
The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied, but its mechanisms of
Externí odkaz:
https://doaj.org/article/c1de44c222424f55b2ca3406c6f3a587
Autor:
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Small cell lung cancer (SCLC) is a highly lethal form of lung cancer. The high mutation burden in SCLC cells makes it challenging to predict key drivers of SCLC from genome sequencing data, thereby hindering the identification of possible therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a245b2d42e0fb8a95800389ec98308e0
https://doi.org/10.1101/2022.03.28.485708
https://doi.org/10.1101/2022.03.28.485708
Autor:
Cong Ran, David C. Qian, David W. Roberts, Chao Cheng, Brent T. Harris, Mark A. Israel, Damian A. Almiron Bonnin, Linton T. Evans, Keith D. Paulsen, Pablo A. Valdés, Matthew C. Havrda, Lia X. Harrington, Myung Chang Lee, Christopher I. Amos
Publikováno v:
Journal of Neurosurgery. 132:1706-1714
OBJECTIVE5-aminolevulinic acid (5-ALA)–induced protoporphyrin IX (PpIX) fluorescence is an effective surgical adjunct for the intraoperative identification of tumor tissue during resection of high-grade gliomas. The use of 5-ALA-induced PpIX fluore
Autor:
Alyssa Puno, Fangfei Qu, Angus Toland, Dian Yang, Anca M. Pasca, Wojciech Michno, Myung Chang Lee, Millie Das, Siqi Cao, Chioma J. Madubata, Christina S. Kong, Monte M. Winslow, Alexandros P. Drainas, Julien Sage
Brain metastasis is a major cause of morbidity and mortality in cancer patients. Here we investigated mechanisms allowing small-cell lung cancer (SCLC) cells to grow in the brain. We show that SCLC cells undergo a cell state transition towards neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c6e6ea68d898f0c54ea831773c5269
https://doi.org/10.1101/2021.08.10.455426
https://doi.org/10.1101/2021.08.10.455426
Autor:
Xavier Rovira-Clavé, Alexandros P. Drainas, Sizun Jiang, Yunhao Bai, Maya Baron, Bokai Zhu, Alec E. Dallas, Myung Chang Lee, Theresa P. Chu, Alessandra Holzem, Ramya Ayyagari, Debadrita Bhattacharya, Erin F. McCaffrey, Noah F. Greenwald, Maxim Markovic, Garry L. Coles, Michael Angelo, Michael C. Bassik, Julien Sage, Garry P. Nolan
Publikováno v:
Cancer cell. 40(11)
Intratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response to treatment. Current technologies are still largely unsuitable to accurately track phenotypes and clonal evolution within tumors, especial
Publikováno v:
Genes Dev
As one of the most common forms of cancer, lung cancers present as a collection of different histological subtypes. These subtypes are characterized by distinct sets of driver mutations and phenotypic appearance, and they often show varying degrees o
Autor:
Jaya Sangodkar, Nevan J. Krogan, Myung Chang Lee, Julia Arand, Janos Demeter, Christina S. Kong, Yeonjoo C. Hwang, Michael Ohlmeyer, Rebecca S. Levin, Julie H. Ko, Kevan M. Shokat, Garry L. Coles, John D. Gordan, James T. Webber, Julien Sage, Peter K. Jackson, Brandon Mauch, Steven M. Moss, Yan Ting Shue, Danielle L. Swaney, Nancie Mooney, Vicky Le, Sandra Cristea, Jessica N. Spradlin, Daniel K. Nomura, Goutham Narla, Andy He, Alexandros P. Drainas
Publikováno v:
Cancer cell, vol 38, iss 1
Cancer Cell
Cancer Cell
Summary Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, suppresses SCLC ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dee69fb505c4d4c08908c08dfb21b63
https://escholarship.org/uc/item/5rk5q37z
https://escholarship.org/uc/item/5rk5q37z
Autor:
Si-Han Chen, Danielle L. Swaney, Christopher W. Murray, Billy W. Newton, Jeffrey R. Johnson, Jose A. Seoane, Preethi Srinivasan, Susan Q. Hipkins, Julien Sage, Chuan Li, Andrea C. Chaikovsky, Peter K. Jackson, Samuel Loebell, Christina Curtis, Myung Chang Lee, Dmitri A. Petrov, Carson D. Poltorack, Janos Demeter, Akihiro Yoshida, J. Alan Diehl, Edwin E. Jeng, Michael C. Bassik, Monte M. Winslow, Yan Ting Shue, Christina S. Kong, Alexandros P. Drainas, Edel McCrea, Nevan J. Krogan, Andy He, Ran Cheng
Publikováno v:
Nature
The initiation of cell division integrates a large number of intra- and extracellular inputs. D-type cyclins (hereafter, cyclin D) couple these inputs to the initiation of DNA replication1. Increased levels of cyclin D promote cell division by activa
Autor:
Leah M. Backhus, Harrison Konsker, Huibin Tang, Thomas A. Burdon, Winston Trope, Emmanuel Fatodu, Myung Chang Lee, Joseph B. Shrager, Jeffrey A. Norton, Yoyo Wang, Shannon Nesbit, Mark S. Berry, George Poulstides, Roger Cooke
Publikováno v:
Respir Med
Introduction Ventilator-induced diaphragm dysfunction (VIDD) is an important phenomenon that has been repeatedly demonstrated in experimental and clinical models of mechanical ventilation. Even a few hours of MV initiates signaling cascades that resu