Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Myrthel E. Hargrove"'
Publikováno v:
International Journal of Cancer. 53:973-977
The effects of PMA and staurosporine (PKC depletor/antagonist) and IL-2/IL4 were used to determine the role of PKC and cytokine on alpha CD3-induced activated killer cells (CD3-AK). The present study examines their effects on the production of BLT-es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8caf57cbbf0b15b53576d7573d628281
https://doi.org/10.1002/ijc.2910530619
https://doi.org/10.1002/ijc.2910530619
Publikováno v:
Cellular Immunology. 160:286-296
This study examined the role of protein tyrosine kinase (PTK) and protein kinase C (PKC) in the signal transduction pathways for lymphocyte activation through IL-2R to generate LAK cells and through TCR—CD3 to generate CD3-AK cells. Two PTK inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e56631f6874568797cd25bb75a692c
https://doi.org/10.1016/0008-8749(95)80040-p
https://doi.org/10.1016/0008-8749(95)80040-p
Publikováno v:
Cellular Immunology. 149:433-443
Glutathione (GSH) was shown to regulate the generation of IL-2-dependent activated killer cells. Generation of alpha CD3-activated killer cells CD3-AK was regulated by both IL-2 and IL-4. In the present study the role of GSH in the regulation of IL-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37221a1e5b6ddb480bea905e759863a1
https://doi.org/10.1006/cimm.1993.1168
https://doi.org/10.1006/cimm.1993.1168
Publikováno v:
Cellular Immunology. 142:40-53
The present study has examined the effect of GSH on two lines of IL-2-dependent activated killer cells, LAK cells and alpha CD3-activated killer (CD3-AK) cells. We found that GSH added during first 24 hr decreased the generation of LAK and CD3-AK cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6c12d9c3758e161480df6726642351
https://doi.org/10.1016/0008-8749(92)90267-s
https://doi.org/10.1016/0008-8749(92)90267-s
Autor:
Myrthel E. Hargrove, Chou-Chik Ting
Publikováno v:
Cellular Immunology. 140:130-144
αCD3 induced the generation of activated killer cells from resting T cells. Pretreatment of the splenic responders with PMA, a phorbol ester, depleted protein kinase C and induced unrespon-siveness to the generation of αCD3-induced activated killer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8840c6279cfd00069f62ea609b14c60
https://doi.org/10.1016/0008-8749(92)90182-o
https://doi.org/10.1016/0008-8749(92)90182-o
Publikováno v:
Immunological Investigations. 19:347-361
The present study has characterized two sets of alpha CD3-induced activated killer cells (CD3-AK). A 2 to 4-h 51Cr release assay or triton-treated 125IUdR release assay demonstrated that CD3-AK cultured in the continuous presence of alpha CD3 (CD3-AK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2dd213ab476cd84aaa8a4dfbb76a9a
https://doi.org/10.3109/08820139009050775
https://doi.org/10.3109/08820139009050775
Publikováno v:
Cellular immunology. 174(2)
The present study has examined the role of IL-2 and IL-4 in the regulation of different kinase pathways for the generation of αCD3-induced activated killer cells, CD3-AK. It has previously been shown that the IL-2 promoted CD3-AK cell response is me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024131f57aac9a3733991803ecb30d22
https://pubmed.ncbi.nlm.nih.gov/8954613
https://pubmed.ncbi.nlm.nih.gov/8954613
Publikováno v:
Immunopharmacology. 30(2)
The present study explores a model for tumor cell-induced immunosuppression and reversal of suppression by cytokines and other pharmacological agents. To simulate tumor-cell-induced suppression, a panel of suppressor agents which included CsA (cyclos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9679712033126ca7b4673aff8a529470
https://pubmed.ncbi.nlm.nih.gov/8530253
https://pubmed.ncbi.nlm.nih.gov/8530253
Autor:
Chou-Chik Ting, Myrthel E. Hargrove
Publikováno v:
Cellular Immunology. 112:123-134
The expression and function of asialo-GM1 (AsGM1) in alloreactive cytotoxic T lymphocytes (CTL) was studied. We have shown previously that the cytotoxic reactions mediated by AsGM1 + -cloned CTL were blocked by anti-AsGM1 or by purified AsGM1. To fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a18754ba68655373a61d0c720b694a
https://doi.org/10.1016/0008-8749(88)90281-x
https://doi.org/10.1016/0008-8749(88)90281-x
Publikováno v:
Cellular Immunology. 73:275-289
The present study reports the establishment of an NK (natural killer) cell line, designated as IL2-CE1. This cell line was maintained in active growth in culture with the supplementation of interleukin 2 (IL2). The cells gave cytotoxicity against a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f4642d1e36095b038eb7ef4f9ca410b
https://doi.org/10.1016/0008-8749(82)90455-5
https://doi.org/10.1016/0008-8749(82)90455-5