Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Myrthala Moreno-Smith"'
Autor:
Ling Tao, Mahmoud A. Mohammad, Giorgio Milazzo, Myrthala Moreno-Smith, Tajhal D. Patel, Barry Zorman, Andrew Badachhape, Blanca E. Hernandez, Amber B. Wolf, Zihua Zeng, Jennifer H. Foster, Sara Aloisi, Pavel Sumazin, Youli Zu, John Hicks, Ketan B. Ghaghada, Nagireddy Putluri, Giovanni Perini, Cristian Coarfa, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical mo
Externí odkaz:
https://doaj.org/article/f46634316a174b53a1daa084ab8c5d23
Autor:
Joanna S. Yi, Oscar Sias-Garcia, Nicole Nasholm, Xiaoyu Hu, Amanda Balboni Iniguez, Matthew D. Hall, Mindy Davis, Rajarshi Guha, Myrthala Moreno-Smith, Eveline Barbieri, Kevin Duong, Jessica Koach, Jun Qi, James E. Bradner, Kimberly Stegmaier, William A. Weiss, W. Clay Gustafson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 6, Pp 624-633 (2021)
Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription. Here we sought to identify
Externí odkaz:
https://doaj.org/article/e7ee05c4dfde46b7a9eedd9150ea3b8c
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Ling Tao, Myrthala Moreno‐Smith, Rodrigo Ibarra‐García‐Padilla, Giorgio Milazzo, Nathan A. Drolet, Blanca E. Hernandez, Young S. Oh, Ivanshi Patel, Jean J. Kim, Barry Zorman, Tajhal Patel, Abu Hena Mostafa Kamal, Yanling Zhao, John Hicks, Sanjeev A. Vasudevan, Nagireddy Putluri, Cristian Coarfa, Pavel Sumazin, Giovanni Perini, Ronald J. Parchem, Rosa A. Uribe, Eveline Barbieri
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients respond, and most NBs event
Externí odkaz:
https://doaj.org/article/0d8406c5d32841488bb0468840a3531b
Autor:
Jennifer H. Foster, Eveline Barbieri, Linna Zhang, Kathleen A. Scorsone, Myrthala Moreno-Smith, Peter Zage, Terzah M. Horton
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6565 (2021)
Pevonedistat is a neddylation inhibitor that blocks proteasomal degradation of cullin–RING ligase (CRL) proteins involved in the degradation of short-lived regulatory proteins, including those involved with cell-cycle regulation. We determined the
Externí odkaz:
https://doaj.org/article/674cae13e9fc4d49be3e1534645fd75f
Autor:
Myrthala Moreno-Smith, Sun Joo Lee, Chunhua Lu, Archana S Nagaraja, Guangan He, Rajesha Rupaimoole, Hee Dong Han, Nicholas B Jennings, Ju-Won Roh, Masato Nishimura, Yu Kang, Julie K Allen, Guillermo N Armaiz, Koji Matsuo, Mian M K Shahzad, Justin Bottsford-Miller, Robert R Langley, Steve W Cole, Susan K Lutgendorf, Zahid H Siddik, Anil K Sood
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 502-510 (2013)
Chronic sympathetic nervous system activation results in increased angiogenesis and tumor growth in orthotopic mouse models of ovarian carcinoma. However, the mechanistic effects of such activation on the tumor vasculature are not well understood. Do
Externí odkaz:
https://doaj.org/article/c038a14994e24300a16ad6c36cef2b13
Autor:
Anil K. Sood, Mariella De Biasi, Susan K. Lutgendorf, Steve W. Cole, Gabriel Lopez-Berestein, Frank C. Marini, Stephen T.C. Wong, Prahlad T. Ram, Erika L. Spaeth, Vasudha Sehgal, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Yu Kang, Myrthala Moreno-Smith, Justin Bottsford-Miller, Wei Hu, Morgan Taylor, Heather J. Dalton, Behrouz Zand, Hee Dong Han, Xiaoyun Xu, Sunila Pradeep, Sherry Y. Wu, Rebecca A. Previs, Rajesha Rupaimoole, Kshipra M. Gharpure, Monika Haemmerle, Danielle M. Herder, Merve Ozcan, Robert Dood, Tatiana Ortiz, Nouara C. Sadaoui, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Julie K. Allen
Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed3bdd54947735db8752aa11a065611
https://doi.org/10.1158/0008-5472.c.6509690.v1
https://doi.org/10.1158/0008-5472.c.6509690.v1
Autor:
Eveline Barbieri, Jason M. Shohet, Silke Paust, Eugene S. Kim, Vivien Sheehan, Sanjeev A. Vasudevan, Jan J. Molenaar, Rikhia Chakraborty, Yankai Zhang, Rana Nikzad, Kevin Aviles-Padilla, Linda Schild, Kathleen A. Scorsone, Ling Tao, Zaowen Chen, Anna Lakoma, Myrthala Moreno-Smith
Survivin protein determination in multiple neuroblastoma lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324b38f5884525187183b05cbff54dee
https://doi.org/10.1158/1078-0432.22468167
https://doi.org/10.1158/1078-0432.22468167
Autor:
Anil K. Sood, Parkash S. Gill, Gabriel Lopez-Berestein, Valery Krasnoperov, Yue Zhou, Pablo E. Vivas-Mejia, Robert L. Coleman, William M. Merritt, Yvonne G. Lin, Nicholas B. Jennings, Ren Liu, Alpa M. Nick, Myrthala Moreno-Smith, Sun-Joo Lee, Mian M.K. Shahzad, Masato Nishimura, Amy R. Carroll, Rebecca L. Stone, Lingegowda S. Mangala, Whitney A. Spannuth
EphB4 is a transmembrane receptor tyrosine kinase that plays an important role in neural plasticity and angiogenesis. EphB4 is overexpressed in ovarian cancer and is predictive of poor clinical outcome. However, the biological significance of EphB4 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8501cbac8362877b0e4244ba73e2362c
https://doi.org/10.1158/1535-7163.c.6531744
https://doi.org/10.1158/1535-7163.c.6531744
Autor:
Eveline Barbieri, Jason M. Shohet, Silke Paust, Eugene S. Kim, Vivien Sheehan, Sanjeev A. Vasudevan, Jan J. Molenaar, Rikhia Chakraborty, Yankai Zhang, Rana Nikzad, Kevin Aviles-Padilla, Linda Schild, Kathleen A. Scorsone, Ling Tao, Zaowen Chen, Anna Lakoma, Myrthala Moreno-Smith
Purpose: mTORC1 inhibitors are promising agents for neuroblastoma therapy; however, they have shown limited clinical activity as monotherapy, thus rational drug combinations need to be explored to improve efficacy. Importantly, neuroblastoma maintain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e1854cdfe0feda0db08be80b004f1e
https://doi.org/10.1158/1078-0432.c.6526860
https://doi.org/10.1158/1078-0432.c.6526860