Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Myron L. Seligman"'
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Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury
Autor: Myron L. Seligman, Harry B. Demopoulos, Dennis D. Pietronigro, V. DeCrescito, J. J. Tomasula, Eugene S. Flamm
Publikováno v: Canadian Journal of Physiology and Pharmacology. 60:1415-1424
The hypothesis that pathologic free-radical reactions are initiated and catalyzed in the major central nervous system (CNS) disorders has been further supported by the current acute spinal cord injury work that has demonstrated the appearance of spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ace4d8f1ce256909d0175fbda8b8d5
https://doi.org/10.1139/y82-210
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3
Loss of Essential Membrane Lipids and Ascorbic Acid from Rat Brain following Cryogenic Injury and Protection by Methylprednisolone
Autor: Myron L. Seligman, John A. Mitamura, Joseph Ransohoff, Harry B. Demopoulos, Eugene S. Flamm, Jerome J. Solomon
Publikováno v: Neurological Research. 3:329-344
Previous work has shown that unsaturated fatty acid components of model membrane phospholipids in vitro, damaged via a free radical mechanism, are protected by the presence of cholesterol in these membranes. The participation of these membrane lipids
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d0ca8a31ecfae778840c86f8680df
https://doi.org/10.1080/01616412.1981.11739608
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4
Interactions of immunoglobulins with liposomes: An ESR and diffusion study demonstrating protection by hydrocortisone
Autor: Gerald Weissmann, Myron L. Seligman, Hugh Schieren, Peter S. Coleman
Publikováno v: Biochemical and Biophysical Research Communications. 82:1160-1167
Heat-aggregated IgG, used as a surrogate for immunoglobulin configuration in immune complexes, mobilized a hydrophobic spin probe within bilayers of anionic liposomes, whereas native IgG was ineffective. Hydrocortisone, preincorporated into liposomal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d38a96f2ab5ca957edd2abcbcb632e
https://doi.org/10.1016/0006-291x(78)90308-x
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5
Spectrofluorescent detection of malonaldehyde as a measure of lipid free radical damage in response to ethanol potentiation of spinal cord trauma
Autor: Myron L. Seligman, Richard G. Poser, Joseph Ransohoff, Bernard D. Goldstein, Eugene S. Flamm, Harry B. Demopoulos
Publikováno v: Lipids. 12:945-950
Studies of the role of free radical damage to the spinal cord following a 400 g-cm impact have suggested an increase in at least one free radical product, malonaldehyde, 24–36 hr post injury. To investigate further the role of free radical lipid pe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cc60b10390b5747f17de8c2c8dc6e0
https://doi.org/10.1007/bf02533316
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6
Ethanol potentiation of central nervous system trauma
Autor: Myron L. Seligman, Harry B. Demopoulos, Eugene S. Flamm, Joseph Ransohoff, John J. Tomasula, V. De Crescito
Publikováno v: Journal of Neurosurgery. 46:328-335
✓ Two models have been used to study the effects of ethanol on injuries of the central nervous system. The spinal cords of cats were injured by delivering a 200 gm-cm impact to the exposed dura mater. A second group of animals received a similar in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a684353d8e440e7c2062de512405ad
https://doi.org/10.3171/jns.1977.46.3.0328
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7
Lipid antioxidant properties of naloxone in vitro
Autor: Myron L. Seligman, Eugene S. Flamm, Harry B. Demopoulos, Kinga Koréh
Publikováno v: Biochemical and Biophysical Research Communications. 102:1317-1322
Summary The results of this study indicate that naloxone diminishes ironinitiated and catalyzed peroxidation in liposomes in a concentration-dependent manner. This supports the hypothesis that the action of naloxone in vivo during amelioration of spi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dfb155a2b168c02795c04b0ca2a542
https://doi.org/10.1016/s0006-291x(81)80155-6
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8
CORTICOSTEROID (METHYLPREDNISOLONE) MODULATION OF PHOTOPEROXIDATION BY ULTRAVIOLET LIGHT IN LIPOSOMES
Autor: Myron L. Seligman, N. Shera, J. Mitamura, Harry B. Demopoulos
Publikováno v: Photochemistry and Photobiology. 29:549-558
— UV irradiation of ovolecithin liposomes produced a dose dependent wave of peroxidation which reached a peak and then fell again coincident with substrate exhaustion. This correlated well with subsequent increases in membrane permeability. There w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3164a894ac7912c83099474560e350dc
https://doi.org/10.1111/j.1751-1097.1979.tb07089.x
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10
Free radicals in cerebral ischemia
Autor: Myron L. Seligman, Harry B. Demopoulos, Joseph Ransohoff, Eugene S. Flamm, Richard G. Poser
Publikováno v: Stroke. 9:445-447
The possibility that cerebral ischemia may initiate a series of pathological free radical reactions within the membrane components of the CNS was investigated in the cat. The normally occurring electron transport radicals require adequate molecular o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252dac6a1052005a1966df56acfa043e
https://doi.org/10.1161/01.str.9.5.445
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