Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Myrna E. Trumbauer"'
Autor:
Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski
Publikováno v:
Molecular Endocrinology. 17:93-106
Somatostatin (SRIF) regulates pancreatic insulin and glucagon secretion. In the present study we describe the generation of SRIF receptor subtype 5 knockout (sst(5) KO) mice to examine the role of SRIF receptor subtypes (sst) in regulating insulin se
Autor:
Xiao-Ming Guan, Douglas J. MacNeil, Myrna E. Trumbauer, Dawn E. Novi, Howard Y. Chen, Drew T. Weingarth, Yue Feng, Hong Yu, Airu Chen, Easter G. Frazier, Donald J. Marsh, Ramon E. Camacho, Shobhna Gopal-Truter, Lauren P. Shearman, Lex H.T. Van der Ploeg, Su Qian, Zhu Shen
Publikováno v:
Molecular and Cellular Biology. 22:5027-5035
Agouti-related protein (AgRP), a neuropeptide abundantly expressed in the arcuate nucleus of the hypothalamus, potently stimulates feeding and body weight gain in rodents. AgRP is believed to exert its effects through the blockade of signaling by alp
Autor:
Xiao-Ming Guan, Charles Rosenblum, Hong Yu, Yue Feng, D. Euan MacIntyre, Alison M. Strack, Lex H.T. Van der Ploeg, Christian N. Nunes, Airu S. Chen, Joseph M. Metzger, Linhai Cao, Easter G. Frazier, Jill K. Fisher, Ramon E. Camacho, William Min, Shobhna Gopal-Truter, Aurawan Vongs, Howard Y. Chen, Theodore N. Mellin, Donald J. Marsh, Myrna E. Trumbauer
Publikováno v:
Nature Genetics. 26:97-102
Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocortin receptor expressed at high levels in the hypothalamus, has rema
Autor:
Donald J. Marsh, D. E. Macintyre, Xiao-Ming Guan, Michael J. Forrest, Easter G. Frazier, Airu S. Chen, Theodore N. Mellin, Ramon E. Camacho, Hong Yu, Jill K. Fisher, Van der Ploeg Lh, Joe Metzger, Alison M. Strack, Myrna E. Trumbauer, Howard Y. Chen, Shobhna Gopal-Truter
Publikováno v:
Transgenic Research. 9:145-154
We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic ra
Autor:
Lin–Lin Shiao, Myrna E. Trumbauer, Howard Y. Chen, Margaret A. Cascieri, Kathleen A. Sullivan
Publikováno v:
Transgenic Research. 8:295-302
The process of evaluating the in vivo efficacy of non–peptidyl receptor antagonists in animal models is frequently complicated by failure of compounds displaying high affinity against the human receptors to show measurable affinity at the correspon
Autor:
Kristy L. Kort, Myrna E. Trumbauer, Judith E. Miller, Howard Y. Chen, Deborah R. Marino, Shobhna Gopal, Thomas R. Skopek
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 400:77-88
Transgenic mutation assays utilizing bacterial target genes display a high frequency of spontaneous mutation at CpG sequences. This is believed to result from the fact that: (1) the prokaryotic genes currently being used as transgenic mutation target
Autor:
Irwin I. Singer, John G. Flanagan, Nicole A. Chartrain, A. J. Forsyth, Howard Y. Chen, C. F. Shen, Ellen K. Bayne, Denise M. Visco, John S. Mudgett, Karla Stevens, Myrna E. Trumbauer, Douglas W. Kawka, Nancy I. Hutchinson, Joseph McDonnell
Publikováno v:
Arthritis & Rheumatism. 41:110-121
Objective It has long been proposed that stromelysin is one of the major degradative matrix metalloproteinases responsible for the loss of cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA). This hypothesis was tested by examining the art
Autor:
Philip C. Wong, Myrna E. Trumbauer, Dalip J. S. Sirinathsinghji, Donald L. Price, Lex H.T. Van der Ploeg, Hua Chen, Mark W. Becher, Howard Y. Chen, Sangram S. Sisodia, Hui Zheng
Publikováno v:
Nature. 387:288-292
Approximately 10% of cases of Alzheimer's disease are familial and associated with autosomal dominant inheritance of mutations in genes encoding the amyloid precursor protein1, presenilin 1 (PS1)2 and presenilin 2 (PS2)3,4. Mutations in PS1 are linke
Autor:
R. Hopkins, Howard Y. Chen, Minghao Jiang, Dalip J. S. Sirinathsinghji, Myrna E. Trumbauer, Hui Zheng, Karla Stevens, L. H. T. Ploeg, Sangram S. Sisodia, Hilda H. Slunt, M. W. Conner
Publikováno v:
Annals of the New York Academy of Sciences. 777:421-426
To understand the in vivo function of the amyloid precursor protein (APP) we generated an APP null mutation in mice by homologous recombination in embryonic stem (ES) cells. We show here that homozygous APP deficient mice were produced at expected fr
Autor:
Myrna E. Trumbauer, Daniel S. Fletcher, Karen Sokol, Qiao-wen Xie, Gary J Hom, Carl Nathan, Karla Stevens, John D. MacMicking, Nicole A. Chartrain, John S. Mudget, Nancy I. Hutchinson, Howard Y. Chen
Publikováno v:
Cell. 81(4):641-650
Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that !NOS defends the host against infectious agents and tumor cells at the risk of contributing to tissue damage and shock. iNOS -I- mice failed to restrain the