Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Myriam Lereau-Bernier"'
1
A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocyte-like cells
Autor: Yannick Tauran, Myriam Lereau‐Bernier, Bertrand David Segard, Mathieu Danoy, Keiichi Kimura, Marie Shinohara, Arnaud Brioude, Yasuyuki Sakai, Hugo de Jonge, Oleg Melnyk, Jérôme Vicogne, Eric Leclerc
Publikováno v: Development, growthdifferentiationREFERENCES. 64(9)
Hepatocyte growth factor (HGF) is the natural ligand of the MET receptor tyrosine kinase. This ligand-receptor couple is essential for the maturation process of hepatocytes. Previously, the rational design of a synthetic protein based on the assembly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d77fcc42c0053f98cbeabce2dbc69b4
https://pubmed.ncbi.nlm.nih.gov/36251346
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2
Characterization of liver zonation‐like transcriptomic patterns in HLCs derived from hiPSCs in a microfluidic biochip environment
Autor: Taketomo Kido, Eric Leclerc, Atsushi Miyajima, Benedikt Scheidecker, Stéphane Poulain, Sachi Kato, Charles Plessy, Mathieu Danoy, Myriam Lereau-Bernier, Yasuyuki Sakai
Publikováno v: Biotechnology Progress
Biotechnology Progress, 2020, ⟨10.1002/btpr.3013⟩
Biotechnology Progress, Wiley, 2020, ⟨10.1002/btpr.3013⟩
The liver zonation is an important phenomenon characterized by a gradient of several functions along the liver acinus. However, this gradient remains difficult to reproduce in in-vitro conditions, making the obtention of an in-vitro method to recapit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd18aba4b3bd9bc7dc306a932ad16619
https://hal.science/hal-02884029
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4
Metabolomic profiling during the differentiation of human induced pluripotent stem cells into hepatocyte-like cells
Autor: Yasuyuki Sakai, Taketomo Kido, Françoise Gilard, Atsushi Miyajima, Myriam Lereau Bernier, Mathieu Danoy, Rachid Jellali, Eric Leclerc, Yannick Tauran
Publikováno v: Differentiation
Differentiation, Elsevier, 2020, 112, pp.17-26. ⟨10.1016/j.diff.2019.10.006⟩
Differentiation, 2020, 112, pp.17-26. ⟨10.1016/j.diff.2019.10.006⟩
Human induced pluripotent stem cells (hiPSCs) are potentially an invaluable source of cells for regenerative medicine, disease modeling and drug discovery. However, the differentiation of hiPSCs into fully functional hepatocytes remains a major chall
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fdb71b726c91fef846cc691f60cf9ef
https://hal.archives-ouvertes.fr/hal-02453731
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5
Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells
Autor: Bertrand-David Segard, Sachi Kato, Atsushi Miyajima, Marie Shinohara, Charles Plessy, Taketomo Kido, Mathieu Danoy, Stéphane Poulain, Myriam Lereau-Bernier, Eric Leclerc, Yannick Tauran, Yasuyuki Sakai
Publikováno v: Molecular Omics
Molecular Omics, Royal Society of Chemistry 2019, ⟨10.1039/C9MO00122K⟩
International audience; We investigated the human induced pluripotent stem cells (hiPSCs) during a sequential in vitro step-by-step differentiation into hepatocyte-like cells (HLCs) using nanoCAGE, a method for promoters, transcription factors, and t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13fffd0fd787987fb7241ecf2eac71b
https://pubmed.ncbi.nlm.nih.gov/31612883
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6
Integration of metabolomic and transcriptomic profiling to compare two protocols of differentiation of human induced pluripotent stem cells into hepatocytes
Autor: Stéphane Poulain, Yasuyuki Sakai, Charles Plessy, Eric Leclerc, Françoise Gilard, Sachi Kato, Myriam Lereau Bernier, Taketomo Kido, Yannick Tauran, Mathieu Danoy, Bertrand-David Segard, Atsushi Miyajima, Rachid Jellali
Publikováno v: Process Biochemistry
Process Biochemistry, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩
Process Biochemistry, Elsevier, 2019, 88, pp.139-147. ⟨10.1016/j.procbio.2019.09.034⟩
International audience; Human hepatocyte-like cells derived from human induced pluripotent stem cells (hiPSC) may provide an unlimited supply of cells for in vitro liver models. However, hiPSC differentiation remains a major challenge due to immaturi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22df9446d53ca7a08daaaa795cb692ef
https://hal.science/hal-02357452
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7
Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment
Autor: Stéphane Poulain, Myriam Lereau Bernier, Hiroyuki Kusuhara, Taketomo Kido, Eric Leclerc, Sachi Kato, Mathieu Danoy, Charles Plessy, Daiki Mori, Atsushi Miyajima, Yasuyuki Sakai, Keiichi Kimura
Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, Wiley, 2019, 116 (7), pp.1762-1776. ⟨10.1002/bit.26970⟩
In the present study, we evaluated the performance of different protocols for the hepatic differentiation of human-induced pluripotent stem cells (hiPSCs) in microfluidic biochips. Strategies for complete and partial on-chip differentiation were test
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c2afe2b56e545fcfe0f6134d6297ae
https://hal.archives-ouvertes.fr/hal-02357453
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8
Profiling of derived-hepatocyte progenitors from induced pluripotent stem cells using nanoCAGE promoter analysis
Autor: Myriam Lereau Bernier, Eric Leclerc, Sachi Kato, Stéphane Poulain, Keiichi Kimura, Yasuyuki Sakai, Charles Plessy, Atsushi Miyajima, Marie Shinohara, Taketomo Kido, Mathieu Danoy, Yannick Tauran, Bertrand-David Segard
Publikováno v: Biochemical Engineering Journal
Biochemical Engineering Journal, Elsevier, 2019, 142, pp.7-17. ⟨10.1016/j.bej.2018.11.001⟩
International audience; Human induced pluripotent stem (hiPS) cells represent a potential source of human cells for regenerative and personalized medicine applications. It is envisioned that hiPS cells could be an efficient tool for disease modelling
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b97f8479c0dc47197c974bb4a779c0e
https://hal.archives-ouvertes.fr/hal-02357456
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