Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Myriam Lemmens"'
Autor:
Myriam Lemmens, Benoit Fischer, Michael Zogg, Lindsey Rodrigues, Grainne Kerr, Alberto del Rio-Espinola, Fanny Schaeffer, Danilo Maddalo, Valerie Dubost, Alessandro Piaia, Arne Mueller, Ulla Plappert-Helbig, Ulrike Naumann, Jasmin Haegele, Alex Odermatt, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 241-253 (2021)
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity assessment of gene therapy products ind
Externí odkaz:
https://doaj.org/article/290bd942646a411a99a58b2d82349198
Autor:
Myriam Lemmens, Juliane Perner, Leon Potgeter, Michael Zogg, Sineha Thiruchelvam, Matthias Müller, Thierry Doll, Annick Werner, Yoann Gilbart, Philippe Couttet, Hans-Jörg Martus, Silvana Libertini
Publikováno v:
Cytotherapy. 25:59-67
Engineered tissues and cell therapies based on human induced pluripotent stem cells (iPSCs) represent a promising approach for novel medicines. However, iPSC-derived cells and tissues may contain residual undifferentiated iPSCs that could lead to ter
Autor:
Lindsey Rodrigues, Arne Mueller, Jasmin Haegele, Alberto Del Rio-Espinola, Silvana Libertini, Danilo Maddalo, Alex Odermatt, Benoit Fischer, Valerie Dubost, Alessandro Piaia, Myriam Lemmens, Ulla Plappert-Helbig, Grainne Kerr, Fanny Schaeffer, Ulrike Naumann, Hans-Jörg Martus, Michael Zogg
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 241-253 (2021)
Off-target editing is one of the main safety concerns for the use of CRISPR-Cas9 genome editing in gene therapy. These unwanted modifications could lead to malignant transformation, which renders tumorigenicity assessment of gene therapy products ind