Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Myriam Didelot"'
Autor:
Camila de-Almeida, Keith R. Mulholland, Kang Zhao, Barlaam Bernard Christophe, Gilles Ouvry, Gareth Hughes, Martin Pass, Elaine Cadogan, Zhenhua Wang, Andrew D. Campbell, Nidal Al-Huniti, Natalie Stratton, Sébastien L. Degorce, Joanne Wilson, Myriam Didelot, Philip A. MacFaul, Stephen T. Durant, Richard Ducray, Baochang Zhai, Kurt Gordon Pike, Lorraine A. Hassall, Jane L. Holmes, Thomas M. McGuire, Nichola L. Davies, Allan Dishington, Yingxue Chen, Nicola Colclough, Graeme R. Robb
Publikováno v:
Journal of Medicinal Chemistry. 61:3823-3841
ATM inhibitors, such as 7, have demonstrated the antitumor potential of ATM inhibition when combined with DNA double-strand break-inducing agents in mouse xenograft models. However, the properties of 7 result in a relatively high predicted clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b8b713635f9878cda9f9cef37bdce
https://doi.org/10.1021/acs.jmedchem.7b01896
https://doi.org/10.1021/acs.jmedchem.7b01896
Autor:
Honorine Lebraud, Christine Lambert-van der Brempt, Paul R. J. Davey, Craig S. Harris, Sébastien L. Degorce, Myriam Didelot, Benedicte Delouvrie, Hervé Germain, Gilles Ouvry
Publikováno v:
Tetrahedron Letters. 53:6078-6082
Access to the 1,5-disubstituted-1 H -1,2,4-triazole-3-carboxamide motif is quite laborious and requires forcing conditions to effect the cyclocondensation step. Herein, we report an efficient and mild one-pot protocol to access this substructure in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07a38dbdd0894dbc8e27b3d34e478c5
https://doi.org/10.1016/j.tetlet.2012.08.130
https://doi.org/10.1016/j.tetlet.2012.08.130
Autor:
Simon T. Barry, A. Hughes, Craig S. Harris, Martin Pass, Benedicte Delouvrie, Jane Kendrew, Michel Vautier, David A. Jude, Hervé Germain, Myriam Didelot, Jean-Jacques Marcel Lohmann, Jean-Claude Arnould, Andrew A. Mortlock, Nicolas Warin, Jennifer L. Vincent, Katherine Al-Kadhimi, Paul R. Gavine, Morgan Ménard, Christine Lambert-van der Brempt, Darren Cross, Claire Rooney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4117-4121
Potent antagonists of the integrin ?(5)?(1), which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930317b9e878eee93e46746ef6da9c53
https://doi.org/10.1016/j.bmcl.2012.04.061
https://doi.org/10.1016/j.bmcl.2012.04.061
Autor:
Bénédicte, Delouvrié, Katherine, Al-Kadhimi, Jean-Claude, Arnould, Simon T, Barry, Darren A E, Cross, Myriam, Didelot, Paul R, Gavine, Hervé, Germain, Craig S, Harris, Adina M, Hughes, David A, Jude, Jane, Kendrew, Christine, Lambert-van der Brempt, Jean-Jacques, Lohmann, Morgan, Ménard, Andrew A, Mortlock, Martin, Pass, Claire, Rooney, Michel, Vautier, Jennifer L, Vincent, Nicolas, Warin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4111-4116
Potent antagonists of the integrin α(5)β(1), which are RGD mimetics built from tyrosine are described. This letter describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the basic group and the linker bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0461240ea9358c4597b4752286cf8269
https://doi.org/10.1016/j.bmcl.2012.04.063
https://doi.org/10.1016/j.bmcl.2012.04.063
Autor:
Antoine Legriffon, Maryannick Lamorlette, Iain Simpson, Richard Ducray, Morgan Ménard, Fabrice Renaud, Hervé Germain, Franck Lach, Georges Rene Pasquet, Myriam Didelot, Pascal Boutron, Mickaël Maudet, Gail L. Young
Publikováno v:
Tetrahedron Letters. 51:4755-4758
A two-step synthesis of 3-(2-chloropyrimidin-4-yl)imidazo[1,2-a]pyridines is presented. The late stage elaboration of the imidazopyridine through a cyclocondensation allows a rapid access to a variety of substitution patterns. The intermediate enol e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0066974efc7809419aca829ff9f3698a
https://doi.org/10.1016/j.tetlet.2010.07.024
https://doi.org/10.1016/j.tetlet.2010.07.024
Autor:
Paul R. J. Davey, Benedicte Delouvrie, Myriam Didelot, Gilles Ouvry, Sébastien L. Degorce, Honorine Lebraud, Hervé Germain, Christine Lambert-van der Brempt, Craig S. Harris
Publikováno v:
ChemInform. 44
Title compounds can be synthesized by stepwise one-pot reaction of aryl carboxylic acids with hydrazines followed by ring closure in the presence of thioxoacetate (IV).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6912fe27f9463f4aaccc3c6d67a1e9
https://doi.org/10.1002/chin.201307115
https://doi.org/10.1002/chin.201307115
Publikováno v:
ChemInform. 27
Aromatic thiols were synthesised from phenols in good yield and under mild conditions by reaction of the corresponding triflates with sodium triisopropylsilanethiolate (NaSTIPS) and subsequent deprotection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff64b626c878b30dae6d47774e12dea1
https://doi.org/10.1002/chin.199640094
https://doi.org/10.1002/chin.199640094
Publikováno v:
Tetrahedron Letters. 37:4523-4524
Aromatic thiols were synthesised from phenols in good yield and under mild conditions by reaction of the corresponding triflates with sodium triisopropylsilanethiolate (NaSTIPS) and subsequent deprotection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd28c463218ddc298ff82ff194a7e74f
https://doi.org/10.1016/0040-4039(96)00873-8
https://doi.org/10.1016/0040-4039(96)00873-8