Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Myriam A Badr"'
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164222 (2016)
Cardiac troponin C (cTnC) is a key effector in cardiac muscle excitation-contraction coupling as the Ca2+ sensing subunit responsible for controlling contraction. In this study, we generated several FRET sensors for divalent cations based on cTnC fla
Externí odkaz:
https://doaj.org/article/038d79cc8b144263a843d331a3061fee
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Striated muscle contraction is regulated by dynamic and cooperative interactions among Ca2+, troponin and tropomyosin on the thin filament. While Ca2+ regulation has been extensively studied, little is known about the dynamics of individual regulator
Externí odkaz:
https://doaj.org/article/c3e62e391ca04394930a971a33defd49
Autor:
Jean Chamoun, Myriam A. Badr, Phani R. Potluri, Roni F. Rayes, Louise J. Brown, Joanna A. Guse, James A. Cooke, Piotr G. Fajer, Dane R. McCamey, Nicole M. Cordina
Publikováno v:
Journal of Structural Biology. 200:376-387
The absence of a crystal structure of the calcium free state of the cardiac isoform of the troponin complex has hindered our understanding of how the simple binding of Ca2+ triggers conformational changes in troponin which are then propagated to enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c96a41bb8bbf969fe49a21517e8c2a
https://doi.org/10.1016/j.jsb.2017.08.007
https://doi.org/10.1016/j.jsb.2017.08.007
Autor:
Myriam A. Badr, Jayalakshmi Ramachandran, J. Patrick Gonzalez, Nadezhda Fefelova, Julie Nouet, Diego Fraidenraich, Lai-Hua Xie, Natalia Shirokova, Jorge E. Contreras, Chifei Kang, Eric Himelman
Publikováno v:
Neuromuscular disorders : NMD. 28(4)
Duchenne muscular dystrophy (DMD) associated cardiomyopathy remains incurable. Connexin 43 (Cx43) is upregulated and remodeled in the hearts of mdx mice, a mouse model of DMD. Hearts from Wild Type, mdx, and mdx:Cx43(+/-) mice were studied before (4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e5d8412a98741087162aa68ce5d8e1
https://pubmed.ncbi.nlm.nih.gov/29477453
https://pubmed.ncbi.nlm.nih.gov/29477453
Deficit in PINK1/PARKIN-mediated mitochondrial autophagy at late stages of dystrophic cardiomyopathy
Publikováno v:
Cardiovascular research. 114(1)
Aims Duchenne muscular dystrophy (DMD) is an inherited devastating muscle disease with severe and often lethal cardiac complications. Emerging evidence suggests that the evolution of the pathology in DMD is accompanied by the accumulation of mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4d34ce58d170eb89af98a6dc57ec04
https://pubmed.ncbi.nlm.nih.gov/29036556
https://pubmed.ncbi.nlm.nih.gov/29036556
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164222 (2016)
PLoS ONE, Vol 11, Iss 10, p e0164222 (2016)
Cardiac troponin C (cTnC) is a key effector in cardiac muscle excitation-contraction coupling as the Ca2+ sensing subunit responsible for controlling contraction. In this study, we generated several FRET sensors for divalent cations based on cTnC fla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5799a74b60570e547811c97affc9fca0
http://europepmc.org/articles/PMC5063504
http://europepmc.org/articles/PMC5063504
Autor:
Natalia Shirokova, Yoshiyuki Ikeda, Sergii Kyrychenko, Junichi Sadoshima, Viktoriia Kyrychenko, Myriam A. Badr
Publikováno v:
Cardiovascular research. 108(3)
Aims Nicotinamide adenine dinucleotide oxidases (NOXs) are important contributors to cellular oxidative stress in the cardiovascular system. The NOX2 isoform is upregulated in numerous disorders, including dystrophic cardiomyopathy, where it drives t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec4adb55b666730623d98899492133b
https://pubmed.ncbi.nlm.nih.gov/26503985
https://pubmed.ncbi.nlm.nih.gov/26503985
Actomyosin kinetics in both skinned skeletal muscle fibers at maximum Ca2+-activation and unregulated in vitro motility assays are modulated by solvent microviscosity in a manner consistent with a diffusion limited process. Viscosity might also influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4450ed3c4cb76d7af305ce61aea622fd
https://europepmc.org/articles/PMC3698987/
https://europepmc.org/articles/PMC3698987/
Publikováno v:
Biophysical Journal. 104(2)
Troponin C (TnC), the Ca2+ binding subunit in striated muscle, is central to regulation of contraction. Crystal structures of skeletal TnC show a rigid, elongated central helix, whereas solution NMR shows it is flexible and unstructured in the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb4a5ed36d8267be0f08571c3816b59
Publikováno v:
Biophysical Journal. 96(3):375a-376a
We have previously shown with skinned skeletal muscle fibers at maximum Ca2+ activation and unregulated in vitro motility assays that solvent viscosity modulates actomyosin function in a manner consistent with diffusional limitation of a kinetic proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc52ed5ed4a04705afca4306e11e5c3