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Efficiency of BRCAPRO and Myriad II mutation probability thresholds versus cancer history criteria alone for BRCA1/2 mutation detection

Autor: Rita D. Brandão, J. J. T. van Harssel, Aimee D C Paulussen, Marinus J. Blok, E. B. Gomez Garcia, Y. Detisch, Maurice P. Zeegers, C. E. P. van Roozendaal

Publikováno v: Familial Cancer, 9(2), 193-201. Springer, Cham
Familial Cancer

Considerable differences exist amongst countries in the mutation probability methods and thresholds used to select patients for BRCA1/2 genetic screening. In order to assess the added value of mutation probability methods, we have retrospectively cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a71f7eff5ecc1a7241f3016c38455c
https://cris.maastrichtuniversity.nl/en/publications/318c2084-ecc3-4ed1-bef5-c9ba38ec3e52

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Abstract P2-12-04: Evaluation of BRCA 1/2 mutation-carrier probability models, BRCAPRO and myriad II, in the Japanese population

Autor: M Ito, A. Furuta, Y. Yasuda, Noriaki Ohuchi

Publikováno v: Cancer Research. 73:P2-12

Background: It is important to select high-risk group with a BRCA1/2 mutation and recommend them to provide genetic counseling and genetic testing. BRCAPRO and Myriad II are widely used for predicting BRCA mutation-carrier probability and useful for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7aa05ccf3607fcbb698eacdaf80eefbb
https://doi.org/10.1158/0008-5472.sabcs13-p2-12-04

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Predicting BRCA1 and BRCA2 gene mutation carriers: comparison of LAMBDA, BRCAPRO, Myriad II, and modified Couch models

Autor: John L. Hopper, Betty A. Mincey, Noralane M. Lindor, Amanda K. Ashley, Katherine S. Hunt, Marcia Wilson, M. Cathie Smith, Rachel A. Lindor, James G. Dowty, Carmel Apicella

Publikováno v: Familial Cancer. 6:473-482

Models have been developed to predict the probability that a person carries a detectable germline mutation in the BRCA1 or BRCA2 genes. Their relative performance in a clinical setting is unclear.To compare the performance characteristics of four BRC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fedc62488eea2c5e30670d97f337e60
https://doi.org/10.1007/s10689-007-9150-z

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