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Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery ofSleeping BeautyTransposons Using Balloon Catheters

Autor: Kendra A. Hyland, R. Scott McIvor, Jason B. Bell, David W. Hunter, Erik R. Olson, Roland Gunther, Perry B. Hackett, Elena L. Aronovich, Myra Rusten

Publikováno v: Human Gene Therapy. 28:541-550

The Sleeping Beauty transposon system has been extensively tested for integration of reporter and therapeutic genes in vitro and in vivo in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b17f61ca01269aded0fc54f5a4897d65
https://doi.org/10.1089/hum.2017.003

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Prolonged Expression of Secreted Enzymes in Dogs After Liver-Directed Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Systemic Disease

Autor: Elena L. Aronovich, Myra Rusten, Jason B. Bell, Bryan C. Hall, David W. Hunter, N. Matthew Ellinwood, R. Scott McIvor, Erik R. Olson, Perry B. Hackett, Kendra A. Hyland

Publikováno v: Human gene therapy. 28(7)

The non-viral, integrating Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic disease in mice, including hemophilia A and B caused by deficiency of blood clotting factors and mucopolysaccharidosis types I and VII cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f921ce5b196844fd855506cec4e681
https://pubmed.ncbi.nlm.nih.gov/28719250

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Calibrated bioresorbable microspheres: a preliminary study on the level of occlusion and arterial distribution in a rabbit kidney model

Autor: Myra Rusten, Lihui Weng, Mehrdad Hairani, Jafar Golzarian, Reza Talaie, Nikolaus K. Rosener

Publikováno v: Journal of vascular and interventional radiology : JVIR. 24(10)

Purpose To assess the level of occlusion and arterial distribution of calibrated bioresorbable microspheres (BRMS-I and BRMS-II) compared with tris-acryl gelatin microspheres (TGMS) after renal embolization. Materials and Methods Six rabbits underwen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430c0abf159f27a540f85d92e0a1d441
https://pubmed.ncbi.nlm.nih.gov/23928298

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439. Prolonged Expression of Secreted Enzymes in Dogs After Liver Delivery of Sleeping Beauty Transposons: Implications for Non-Viral Gene Therapy of Mucopolysaccharidoses Types I and VII

Autor: R. Scott McIvor, Elena L. Aronovich, Myra Rusten, Chester B. Whitley, Kendra A. Hyland, David W. Hunter, Perry B. Hackett, Erik R. Olson, Jason B. Bell, N. Matthew Ellinwood, Bryan C. Hall

Publikováno v: Molecular Therapy. 24:S174

The non-viral integrating vector the Sleeping Beauty (SB) transposon system is efficient in treating systemic monogenic diseases in mice including mucopolysaccharidosis (MPS) types I and VII caused by α-iduronidase (IDUA) and β-glucuronidase (GUSB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b617866458e6ba1a6bbe28f875424c6
https://doi.org/10.1016/s1525-0016(16)33248-8

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