Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Myoung Eun Jung"'
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Novel allosteric glutaminase 1 inhibitors with macrocyclic structure activity relationship analysis
Autor: Eun Ji Lee, Krishna Babu Duggirala, Yujin Lee, Mi Ran Yun, Jiyoon Jang, Rajath Cyriac, Myoung Eun Jung, Gildon Choi, Chong Hak Chae, Byoung Chul Cho, Kwangho Lee
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 75:128956
Glutamine-addicted cancer metabolism is recently recognized as novel cancer target especially for KRAS and KEAP1 co-occurring mutations. Selective glutaminase1 (GLS1) inhibition was reported using BPTES which has novel mode of allosteric inhibition.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0768b09733e649c7383bb537201d0f
https://doi.org/10.1016/j.bmcl.2022.128956
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7
A Study on Preclinical Efficacy, Underlying Mechanisms, and Sensitivity Markers of a Novel Hypomethylating Agent Ntx-301 in Acute Myeloid Leukemia
Autor: Myoung Eun Jung, Gildon Choi, Dabin Yoo, Younghwa Chun, Byungho Lim, Jin Soo Lee, Areum Go, Doo Young Jung, Kyung-jin Cho, Daeun Choi, Ha Young Lee
Publikováno v: Blood. 138:2348-2348
Introduction: While intensive induction chemotherapy has been standard-or-care for patients with acute myeloid leukemia (AML), intensive regimens have often been limited in elderly patients with comorbidities. As an alternative option, less intensive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a0ac5dfa757fcbcac36e3efa0572089
https://doi.org/10.1182/blood-2021-152304
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8
Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma
Autor: Yong Jae Lee, Myoung Eun Jung, Nam-Soon Kim, Jeong-Ju Lee, Areum Go, Su-Jin Jeon, Gildon Choi, Soo Young Jun, Yun-Jeong Heo, Sujin Gu, Ju-Sik Min, Ji-Yong Yoon, Hyun-Soo Cho, Jung Hwa Lim, Kwangho Lee, Min-Hyuk Choi, Moon-Kook Jeon, Cho-Rok Jung, Jun-Ho Ahn
Publikováno v: Oncotarget
// Ji-Yong Yoon 1, * , Jeong-Ju Lee 1, * , Sujin Gu 2 , Myoung Eun Jung 2 , Hyun-Soo Cho 1, 4 , Jung Hwa Lim 3, 4 , Soo Young Jun 1, 4 , Jun-Ho Ahn 1 , Ju-Sik Min 1 , Min-Hyuk Choi 1, 4 , Su-Jin Jeon 1, 4 , Yong-Jae Lee 1 , Areum Go 2, 5 , Yun-Jeong
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15e99dbec114d29ac096a36591469c2
https://doi.org/10.18632/oncotarget.22614
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10
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening
Autor: Myoung Eun Jung, Seong-Jin Kim, You Hwa Son, Yong-Chul Kim, Hye-Mi Kim, Kyung-Min Yang, Sang Un Choi, Gildon Choi, Lee Na Ri, Byung Jin Byun, Joo Yun Lee, Kwangho Lee, Jin-Hee Park
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 26:2719-2723
DRAK2 is a serine/threonine kinase belonging to the death-associated protein kinase (DAPK) family and has emerged as a promising drug target for the treatment of autoimmune diseases and cancers. To identify small molecule inhibitors for DRAK2, we per
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63801700dd77658ad9df00182a03e584
https://doi.org/10.1016/j.bmcl.2016.03.111
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