Výsledky vyhledávání - "Myong Gyong Lee"

Long-Term Ozone Exposure Attenuates 1-Nitronaphthalene–Induced Cytotoxicity in Nasal Mucosa

Autor: Charles G. Plopper, Myong Gyong Lee, Bridget C. Boland, Åsa M. Wheelock

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 38:300-309

1-Nitronaphthalene (1-NN) and ozone are cytotoxic air pollutants commonly found as components of photochemical smog. The mechanism of toxicity for 1-NN involves bioactivation by cytochrome P450s and subsequent adduction to proteins. Previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bd5a769088ad285aa52974e94b1c93
https://doi.org/10.1165/rcmb.2005-0416oc

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Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family

Autor: Jin Kuk Yang, Se Won Suh, Jae Young Lee, Hyun Kyu Song, Myong Gyong Lee, Seung Je Cho

Publikováno v: Proceedings of the National Academy of Sciences. 97:8932-8937

Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c898eafdc4172bcc897ec956a2902db4
https://doi.org/10.1073/pnas.160270897

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Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae

Autor: Kyeongsik Min, Jinho Moon, Hyun Kyu Song, Se Won Suh, Myong Gyong Lee, Jin Kuk Yang, Jae Young Lee

Publikováno v: Journal of Molecular Biology. 293:753-761

“Two-component” phosphorelay signal transduction systems constitute a potential target for antibacterial and antifungal agents, since they are found exclusively in prokaryotes and lower eukaryotes (yeast, fungi, slime mold, and plants) but not in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adf66a879226bfa3266e5f351675e9f
https://doi.org/10.1006/jmbi.1999.3215

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Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction

Autor: Myong Gyong Lee, Hyun Kyu Song, Se Won Suh, Jae Young Lee

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 55:1219-1221

Ypd1p, a 167-residue protein from Saccharomyces cerevisiae, plays a key role in osmosensing phosphorelay signal transduction. It forms part of a multistep phosphorelay system which also includes Sln1p hybrid histidine kinase and two response regulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f47c47ed7c8257e960ec4db5a3dc8a
https://doi.org/10.1107/s0907444999004059

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In situ naphthalene bioactivation and nasal airflow cause region-specific injury patterns in the nasal mucosa of rats exposed to naphthalene by inhalation

Autor: Andrew J. Phimister, Myong Gyong Lee, Alan R. Buckpitt, Dexter Morin, Charles G. Plopper

Publikováno v: The Journal of pharmacology and experimental therapeutics. 314(1)

Despite the fact that naphthalene (NA), a volatile, ubiquitous air pollutant, was recently identified as a probable human carcinogen, little is known about nasal cytotoxicity from inhaled NA. To define and compare acute nasal injury from inhalation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bd5ca2191ac396a99dd7818d5d96bb
https://pubmed.ncbi.nlm.nih.gov/15833892

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Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice

Autor: Myong Gyong Lee, Charles G. Plopper, Andrew J. Phimister, Alan R. Buckpitt, Dexter Morin

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 82(1)

Naphthalene (NA) is metabolized to highly reactive intermediates that are primarily detoxified by conjugation to glutathione (GSH). Intraperitoneal administration of naphthalene causes substantial loss of both hepatic and respiratory GSH, yet only re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56de922686b480be8587563642ee30b
https://pubmed.ncbi.nlm.nih.gov/15319489

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Crystallization and preliminary X-ray crystallographic analysis ofEscherichia coliCyaY, a structural homologue of human frataxin

Autor: Jin Kuk Yang, Seung Je Cho, Hyun Kyu Song, Se Won Suh, Myong Gyong Lee

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 56:920-921

CyaY is a 106-residue protein from Escherichia coli. It shows amino-acid sequence similarity to human frataxin and a frataxin homologue in Saccharomyces cerevisiae, Yfh1p. The former is associated with the disease Friedreich ataxia and the latter pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4aed0a5ffd4b0d52476eaf86db437
https://doi.org/10.1107/s0907444900005916

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Akademický článek

Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the...

Autor: Seung-Je Cho, Myong Gyong Lee

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 08/01/2000, Vol. 97 Issue 16, p8932, 6p, 4 Diagrams, 1 Chart

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Akademický článek

Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CyaY, a structural homologue of human frataxin.

Autor: Myong Gyong Lee, Seung-Je Cho, Jin Kuk Yang, Hyun Kyu Song, Se Won Suh

Publikováno v: Acta Crystallographica: Section D (Wiley-Blackwell); Jul2000, Vol. 56 Issue 7, p920-921, 2p

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