Immortalised murine R349P desmin knock-in myotubes exhibit a reduced proton leak and decreased ADP/ATP translocase levels in purified mitochondria

Autor: Carolin Berwanger, Dominic Terres, Dominik Pesta, Britta Eggers, Katrin Marcus, Ilka Wittig, Rudolf J. Wiesner, Rolf Schröder, Christoph S. Clemen

Publikováno v: European Journal of Cell Biology, Vol 103, Iss 2, Pp 151399- (2024)

Desmin gene mutations cause myopathies and cardiomyopathies. Our previously characterised R349P desminopathy mice, which carry the ortholog of the common human desmin mutation R350P, showed marked alterations in mitochondrial morphology and function

Externí odkaz: https://doaj.org/article/322edd1d0b5e42938e98a96645053b1d

Matrix Architecture and Mechanics Regulate Myofibril Organization, Costamere Assembly, and Contractility in Engineered Myocardial Microtissues.

Autor: DePalma, Samuel J.¹ (AUTHOR), Jilberto, Javiera¹ (AUTHOR), Stis, Austin E.¹ (AUTHOR), Huang, Darcy D.¹ (AUTHOR), Lo, Jason¹ (AUTHOR), Davidson, Christopher D.¹ (AUTHOR), Chowdhury, Aamilah¹ (AUTHOR), Kent, Robert N.¹ (AUTHOR), Jewett, Maggie E.¹ (AUTHOR), Kobeissi, Hiba² (AUTHOR), Chen, Christopher S.^3,4 (AUTHOR), Lejeune, Emma² (AUTHOR), Helms, Adam S.⁵ (AUTHOR), Nordsletten, David A.^1,6,7 (AUTHOR), Baker, Brendon M.^1,8 (AUTHOR) bambren@umich.edu

Publikováno v: Advanced Science. 12/18/2024, Vol. 11 Issue 47, p1-21. 21p.

New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy.

Autor: Yang, Jingmin, Chen, Yanying, Li, Xiao, Xu, Danyan

Publikováno v: Heart Failure Reviews; Jul2022, Vol. 27 Issue 4, p1431-1441, 11p

Endocrine Influence on Cardiac Metabolism in Development and Regeneration.

Autor: Graham, Niall, Huang, Guo N

Publikováno v: Endocrinology; Sep2021, Vol. 162 Issue 9, p1-12, 12p

The giant titin: how to evaluate its role in cardiomyopathies.

Autor: Azad, Amar, Poloni, Giulia, Sontayananon, Naeramit, Jiang, He, Gehmlich, Katja

Publikováno v: Journal of Muscle Research & Cell Motility; Jun2019, Vol. 40 Issue 2, p159-167, 9p