Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells

Autor: Martin Schepelmann, Marianna Ranieri, Irene Lopez-Fernandez, Thomas S. Webberley, Sarah C. Brennan, Polina L. Yarova, Joao Graca, Umar-Khetaab Hanif, Christian Müller, Teresa Manhardt, Martina Salzmann, Helen Quasnichka, Sally A. Price, Donald T. Ward, Thierry Gilbert, Vladimir V. Matchkov, Robert A. Fenton, Amanda Herberger, Jenna Hwong, Christian Santa Maria, Chia-Ling Tu, Enikö Kallay, Giovanna Valenti, Wenhan Chang, Daniela Riccardi

Publikováno v: J Am Soc Nephrol
Schepelmann, M, Ranieri, M, Lopez-Fernandez, I, Webberley, T S, Brennan, S C, Yarova, P L, Graca, J, Hanif, U-K, Müller, C, Manhardt, T, Salzmann, M, Quasnichka, H, Price, S A, Ward, D T, Gilbert, T, Matchkov, V V, Fenton, R A, Herberger, A, Hwong, J, Santa Maria, C, Tu, C-L, Kallay, E, Valenti, G, Chang, W & Riccardi, D 2022, ' Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 7, pp. 1323-1340 . https://doi.org/10.1681/ASN.2021040585
Schepelmann, M, Ranieri, M, Lopez-Fernandez, I, Webberley, T S, Brennan, S C, Yarova, P L, Graca, J, Hanif, U-K, Müller, C, Manhardt, T, Salzmann, M, Quasnichka, H, Price, S A, Ward, D T, Gilbert, T, Matchkov, V V, Fenton, R A, Herberger, A, Hwong, J, Santa Maria, C, Tu, C-L, Kallay, E, Valenti, G, Chang, W & Riccardi, D 2022, ' Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells ', Journal of the American Society of Nephrology : JASN . https://doi.org/10.1681/ASN.2021040585

BACKGROUND: Impaired mineral ion metabolism is a hallmark of CKD-metabolic bone disorder. It can lead to pathologic vascular calcification and is associated with an increased risk of cardiovascular mortality. Loss of calcium-sensing receptor (CaSR) e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a80a8762e559e8d9063bbc47564db68
https://europepmc.org/articles/PMC9257819/

Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles

Autor: Sadia Ahmad, Catherine M. Shanahan, Meredith Whitehead, Rick H. van Gorp, Alexander N. Kapustin, Jayanta Bordoloi, Leon J. Schurgers, Malgorzata Furmanik

Publikováno v: Arteriosclerosis Thrombosis and Vascular Biology, 41(2), 898-914. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, Thrombosis, and Vascular Biology

Supplemental Digital Content is available in the text.
Objective: Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9d18ff4c1e39d6c3f45b31fc08f507
https://cris.maastrichtuniversity.nl/en/publications/9a49fde3-fac5-4516-af6f-f89b05678874

Connexin37‐Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II‐Mediated Hypertension

Autor: Armin Kurtz, Loïc Le Gal, Charlotte Wagner, Jacques-Antoine Haefliger, Maxime Pellegrin, Lucia Mazzolai, Paolo Meda, Tania Santoro

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, vol. 8, no. 8, pp. e010823

Background Gap junction channels made of Connexin37 (Cx37) are expressed by aortic endothelial and smooth muscle cells of hypertensive mice, as well as by the renin‐secreting cells of kidneys. Methods and Results To decipher whether Cx37 has any ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62af2eab2bfa78523c1ba0f790f9de46
http://europepmc.org/articles/PMC6507190

Versican is differentially regulated in the adventitial and medial layers of human vein grafts

Autor: Steve P. Evanko, Michael Sobel, Mark W. Majesky, Thomas N. Wight, Jacques-Antoine Haefliger, Tannin A. Schmidt, Marco Piola, Richard D. Kenagy, Alban Longchamp, Shinsuke Kikuchi, Matthijs S. Ruiter, Monica Soncini, Sébastien Déglise, Maurizio Pesce, Gianfranco Beniamino Fiore

Publikováno v: PloS one, vol. 13, no. 9, pp. e0204045
PLoS ONE
PLoS ONE, Vol 13, Iss 9, p e0204045 (2018)

Changes in extracellular matrix proteins may contribute significantly to the adaptation of vein grafts to the arterial circulation. We examined the production and distribution of versican and hyaluronan in intact human vein rings cultured ex vivo, ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18369a3ee473cdb94e985ba5862266a3
http://hdl.handle.net/11311/1079599

Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study

Autor: Jean-Jacques Meister, Damien Nguyen, N. Piacentini, J. C. Quijano, F. Raynaud

Publikováno v: Scientific Reports
Scientific reports, vol. 6, pp. 31271

Vascular smooth muscle cells exhibit intercellular Ca2+ waves in response to local mechanical or KCl stimulation. Recently, a new type of intercellular Ca2+ wave was observed in vitro in a linear arrangement of smooth muscle cells. The intercellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa931cb249bfbfea757a29b2cfec27bf