Výsledky vyhledávání - "Myocytes, Cardiac/ cytology/ metabolism"

Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation

Autor: Arnaud Ogier, Yangsoo Jang, Jin Hee Ahn, Megumi Eguchi, Bo Yang, Chi Young Shim, Aimin Xu, So Young Chang, Gary Sweeney, Youngsam Park, Guoxiong Xu, Sung-Jun Han, Yu Wang

Our objective was to determine whether lipocalin-2 (Lcn2) regulates cardiomyocyte apoptosis, the mechanisms involved, and the functional significance. Emerging evidence suggests that Lcn2 is a proinflammatory adipokine associated with insulin resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b51871786096b170463908bdfa64c5
http://hdl.handle.net/10722/159703

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Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes

Autor: Roger J. Hajjar, Lin Geng, Deborah K. Lieu, Stephanie N. Rushing, Kenneth R. Boheler, Kitchener D. Wilson, Joseph C. Wu, Chi-Wing Kong, Nipavan Chiamvimonvat, Camie W. Chan, Ronald A. Li, Gordon Keller, Ji-Dong Fu

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27417 (2011)
PloS one, vol 6, iss 11
PLoS ONE

BACKGROUND: MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f79af5c38fc84397dafa2d6542cb8a
http://europepmc.org/articles/PMC3217986?pdf=render

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Absence of Transverse Tubules Contributes to Non-Uniform Ca2+ Wavefront in Mouse and Human Embryonic Stem Cell-Derived Cardiomyocytes

Autor: Jing Liu, Amir Abu-Khalil, Thomas R Huser, Chung-Wah Siu, Deborah K. Lieu, Gregory P. McNerney, Hung-Fat Tse, Ronald A. Li

Mouse (m) and human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are known to exhibit immature Ca2+ dynamics such as small whole-cell peak amplitude and slower kinetics relative to those of adult. In this study, we examined the maturity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa6b242ec1ea85ed119cb19e0912fdc
https://pub.uni-bielefeld.de/record/2352502

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Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state

Autor: Ha Tran, Yau-Chi Chan, Dawei Lin, Ronald A. Li, Jennifer C. Moore, Ji-Dong Fu, Hung-Fat Tse

Although both the H1 and HES2 human embryonic stem cell lines (NIH codes: WA01 and ES02, respectively) are capable of forming all three germ layers and their derivatives, various lines of evidence including the need to use different protocols to indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e3b59c589a311d66ca7582f33a7d53
http://hdl.handle.net/10722/77627

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Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach

Autor: Marisa Jaconi, Elisabetta Cerbai, Laura Sartiani, Francesca Stillitano, Alessandro Mugelli, Esther Bettiol

Publikováno v: Stem Cells, Vol. 25, No 5 (2007) pp. 1136-1144

Cardiomyocytes derived from human embryonic stem cells constitute a promising cell source for the regeneration of damaged hearts. The assessment of their in vitro functional properties is mandatory to envisage appropriate cardiac cell-based therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90129402354f8d1251e7ed649b8928a2
https://pubmed.ncbi.nlm.nih.gov/17255522

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