Fine-mapping of retinal vascular complexity loci identifies Notch regulation as a shared mechanism with myocardial infarction outcomes

Autor: Ana Villaplana-Velasco, Marie Pigeyre, Justin Engelmann, Konrad Rawlik, Oriol Canela-Xandri, Claire Tochel, Frida Lona-Durazo, Muthu Rama Krishnan Mookiah, Alex Doney, Esteban J. Parra, Emanuele Trucco, Tom MacGillivray, Kristiina Rannikmae, Albert Tenesa, Erola Pairo-Castineira, Miguel O. Bernabeu

Publikováno v: Villaplana-Velasco, A, Pigeyre, M, Engelmann, J, Rawlik, K, Canela-Xandri, O, Tochel, C, Lona-Durazo, F, Mookiah, M R K, Doney, A, Parra, E J, Trucco, E, MacGillivray, T, Rannikmae, K, Tenesa, A, Pairo-Castineira, E & Bernabeu, M O 2023, ' Fine-mapping of retinal vascular complexity loci identifies Notch regulation as a shared mechanism with myocardial infarction outcomes ', Communications biology, vol. 6, no. 1, 523, pp. 1-13 . https://doi.org/10.1038/s42003-023-04836-9

There is increasing evidence that the complexity of the retinal vasculature measured as fractal dimension, Df, might offer earlier insights into the progression of coronary artery disease (CAD) before traditional biomarkers can be detected. This asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaa0cf63306bb8a888d499f25ad59a3
https://doi.org/10.1038/s42003-023-04836-9

Monocyte subpopulation profiling indicates CDK6-derived cell differentiation and identifies subpopulation-specific miRNA expression sets in acute and stable coronary artery disease

Autor: Witten, Anika, Martens, Leonie, Schäfer, Ann-Christin, Troidl, Christian, Pankuweit, Sabine, Vlacil, Ann-Kathrin, Oberoi, Raghav, Schieffer, Bernhard, Grote, Karsten, Stoll, Monika, Markus, Birgit

Publikováno v: Scientific Reports, 12(1):5589. Nature Publishing Group

Coronary artery disease (CAD) is a long-lasting inflammatory disease characterized by monocyte migration into the vessel wall leading to clinical events like myocardial infarction (MI). However, the role of monocyte subsets, especially their miRNA-dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7eb7eff442d3ec6fa22a63645b60f465
https://cris.maastrichtuniversity.nl/en/publications/3982a2b9-3697-4629-9d1a-9562fac5d8d4

Eur Heart J

Autor: Yoichiro Kamatani, Markus Scholz, Pin Huang, Marcus E. Kleber, Chang Liu, Aldons J. Lusis, Zhiheng Cai, Janet Gukasyan, Yi Han, Georgios J. Vlachojannis, W.H. Wilson Tang, Satoshi Koyama, Johan L.M. Björkegren, Margarete Mehrabian, David-Alexandre Trégouët, Hooman Allayee, Folkert W. Asselbergs, Peter Bazeley, Elizabeth R. Hauser, Casey E. Romanoski, Mohammad Daud Khan, Leo-Pekka Lyytikäinen, Riyaz S. Patel, Issei Komuro, Tuomo Nieminen, Stanley L. Hazen, Qiong Jia, Muredach P. Reilly, Redouane Aherrahrou, Xuling Chang, Jari Laurikka, James R. Hilser, Marion van Vugt, William E. Kraus, Clint L. Miller, Kaoru Ito, Jaana Hartiala, Marcus M. Seldin, Calvin Pan, Winfried März, Joachim Thiery, Jane F. Ferguson, Yan V. Sun, Chew-Kiat Heng, Pekka Kuukasjärvi, Mika Kähönen, Mete Civelek, Lindsey K. Stolze, S. Ram Kumar, Graciela E. Delgado, Nicholas L. Smith, Subarna Biswas, William S Schwartzman, Laurence J. Howe, Lijiang Ma, Rong Jiang, Adam W. Turner, Arshed A. Quyyumi, Terho Lehtimäki

Publikováno v: European heart journal, 42(9), 919-933. Oxford University Press
European Heart Journal
European Heart Journal, Oxford University Press (OUP): Policy B, 2021, 42 (9), pp.919-933. ⟨10.1093/eurheartj/ehaa1040⟩
Eur Heart J

Aims While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5bb52be241735a34ae518e70c9887d
https://pure.amc.nl/en/publications/genomewide-analysis-identifies-novel-susceptibility-loci-for-myocardial-infarction(e7f8ae9d-382a-4c71-b802-becde244c648).html

Exosomal Expression of CXCR4 Targets Cardioprotective Vesicles to Myocardial Infarction and Improves Outcome after Systemic Administration

Autor: Giuseppe Vassalli, Giovanni G. Camici, Sara Bolis, Elisabetta Cervio, Giuseppina Milano, Vanessa Biemmi, A. Ciullo, Tiziano Moccetti, Emanuel T. Fertig, Lucio Barile, Mihaela Gherghiceanu

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 3, p 468 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 3
International journal of molecular sciences, vol. 20, no. 3

Cell therapy has been evaluated to enhance heart function after injury. Delivered cells mostly act via paracrine mechanisms, including secreted growth factors, cytokines, and vesicles, such as exosomes (Exo). Intramyocardial injection of cardiac-resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd80ce773ca01cb03b66b6207e52de7
https://www.mdpi.com/1422-0067/20/3/468

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Autor: Anne-Claire Vergnaud, Nauder Faraday, Tim Kacprowski, Lisa R. Yanek, Oscar H. Franco, Yongmei Liu, Andreas Greinacher, Gina M. Peloso, Cristen J. Willer, Leslie A. Lange, Eric S. Torstenson, Reedik Mägi, Jeanette Erdmann, Ethan M. Lange, Deborah A. Nickerson, Henry Völzke, David R. Crosslin, Gunnar Engström, Albert V. Smith, André G. Uitterlinden, Salman M. Tajuddin, W. David Hill, Diane M. Becker, Paul Elliot, Caterina Vacchi-Suzzi, Linda M. Polfus, Traci M. Bartz, Nathalie Chami, Abbas Dehghan, Mike A. Nalls, John D. Eicher, Leo-Pekka Lyytikäinen, Evelin Mihailov, Uwe Völker, Caroline Hayward, Ioanna Tzoulaki, Myriam Fornage, Marju Orho-Melander, Mary Cushman, Lars Wallentin, Terho Lehtimäki, Ayush Giri, Laura M. Raffield, Lewis C. Becker, Yingchang Lu, Emma Raitoharju, Sekar Kathiresan, Simon de Denus, Ruth J. F. Loos, James S. Floyd, Dawn M. Waterworth, James G. Wilson, Nathan Pankratz, Lenore J. Launer, Andrew D. Johnson, Andrew J. Slater, Jean-Claude Tardif, Raha Pazoki, Evangelos Evangelou, Kenneth Rice, Harvey D. White, Marie-Pierre Dubé, Frank J. A. van Rooij, Akihiro Nomura, Tamara B. Harris, Vilmundur Gudnason, Gonçalo R. Abecasis, Alan B. Zonderman, Guillaume Lettre, Todd L. Edwards, Amber A. Burt, Ani Manichaikul, Heribert Schunkert, Ming-Huei Chen, Ian J. Deary, Michelle L. O'Donoghue, Jennifer A. Brody, Russell P. Tracy, Tõnu Esko, Mika Kähönen, Panos Deloukas, Eric Boerwinkle, Rasika A. Mathias, Dajiang J. Liu, Jin Li, Santhi K. Ganesh, David C. Liewald, Paul L. Auer, Digna R. Velez Edwards, Erwin P. Bottinger, Nina Mononen, Claudia Schurmann, Michele K. Evans, John M. Starr, Thomas Thiele, Jussi Hernesniemi, Jerome I. Rotter, Rakale C. Quarells, He Gao, Kjell Nikus, Stephen S. Rich, Heather M. Highland, Bruce M. Psaty, Ursula M. Schick, Andres Metspalu, Melissa A. Richard, Neil A. Zakai, Olle Melander, John D. Rioux, Olli T. Raitakari, Alexander P. Reiner, Joel N. Hirschhorn, Nilesh J. Samani

Publikováno v: American Journal of Human Genetics, 99(1), 40-55. Cell Press
Eicher, J D, Chami, N, Kacprowski, T, Nomura, A, Chen, M-H, Yanek, L R, Tajuddin, S M, Schick, U M, Slater, A J, Pankratz, N, Polfus, L, Schurmann, C, Giri, A, Brody, J A, Lange, L A, Manichaikul, A, Hill, W D, Pazoki, R, Elliot, P, Evangelou, E, Tzoulaki, I, Gao, H, Vergnaud, A-C, Mathias, R A, Becker, D M, Becker, L C, Burt, A, Crosslin, D R, Lyytikäinen, L-P, Nikus, K, Hernesniemi, J, Kähönen, M, Raitoharju, E, Mononen, N, Raitakari, O T, Lehtimäki, T, Cushman, M, Zakai, N A, Nickerson, D A, Raffield, L M, Quarells, R, Willer, C J, Peloso, G M, Abecasis, G R, Liu, D J, Deloukas, P, Starr, J M, Liewald, D C M & Hayward, C & Deary, I J 2016, ' Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals ', American Journal of Human Genetics, vol. 99, no. 1, pp. 40-55 . https://doi.org/10.1016/j.ajhg.2016.05.005
The American Journal of Human Genetics

Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d29acca27b4a34b35a3f588b7f78da1
https://pure.eur.nl/en/publications/1465b06f-411f-49c0-a589-3e97bc2a5f08