The antibiotic doxycycline impairs cardiac mitochondrial and contractile function

Autor: Diederik W. D. Kuster, Michel van Weeghel, Vida Alizadeh Tazehkandi, Luciënne Baks-Te Bulte, Gustav J. Strijkers, Bram F. Coolen, Ntsiki M. Held, Bianca J. J. M. Brundel, Riekelt H. Houtkooper, Mariah R R Daal, Marit Wiersma, Rob C. I. Wüst

Publikováno v: Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100 . https://doi.org/10.3390/ijms22084100
International journal of molecular sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(8):4100, 1-19. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 22
Issue 8
Wüst, R C I, Coolen, B F, Held, N M, Daal, M R R, Tazehkandi, V A, Baks-Te Bulte, L, Wiersma, M, Kuster, D W D, Brundel, B J J M, van Weeghel, M, Strijkers, G J & Houtkooper, R H 2021, ' The antibiotic doxycycline impairs cardiac mitochondrial and contractile function ', International Journal of Molecular Sciences, vol. 22, no. 8, 4100, pp. 1-19 . https://doi.org/10.3390/ijms22084100
International Journal of Molecular Sciences, 22(8):4100. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 22, Iss 4100, p 4100 (2021)

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba143ec8e34cf744f53dea11e2bd5101
https://doi.org/10.3390/ijms22084100

Levosimendan in Acute and Advanced Heart Failure : An Appraisal of the Clinical Database and Evaluation of Its Therapeutic Applications

Autor: Gabriella Malfatto, Matti Kivikko, Veli-Pekka Harjola, Johann Altenberger, Finn Gustafsson, Piero Pollesello, Kristjan Karason, Zoltán Papp, Detlef Kindgen-Milles, Carsten Tschöpe, John Parissis, Gerhard Pölzl

Publikováno v: Journal of Cardiovascular Pharmacology
Altenberger, J, Gustafsson, F, Harjola, V-P, Karason, K, Kindgen-Milles, D, Kivikko, M, Malfatto, G, Papp, Z, Parissis, J, Pollesello, P, Pölzl, G & Tschöpe, C 2018, ' Levosimendan in Acute and Advanced Heart Failure : An Appraisal of the Clinical Database and Evaluation of Its Therapeutic Applications ', Journal of Cardiovascular Pharmacology, vol. 71, no. 3, pp. 129-136 . https://doi.org/10.1097/FJC.0000000000000533

The use of inotropes for correcting hemodynamic dysfunction in patients with congestive heart failure has been described over many decades. However, negative or insufficient data have been collected regarding the effects of cardiac glycosides, catech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc67f375e178ff6586db68b5bb287804
http://hdl.handle.net/10138/234833

The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation

Autor: Klaus Steger, Marisa Jaconi, Esther Bettiol, Yves Charnay, Lena Serrander, Botond Banfi, Jian Li, Michael Stouffs, Karl-Heinz Krause

Publikováno v: Molecular Biology of the Cell, Vol. 17, No 9 (2006) pp. 3978-3988

Reactive oxygen species (ROS) generated by the NOX family of NADPH oxidases have been described to act as second messengers regulating cell growth and differentiation. However, such a function has hitherto not been convincingly demonstrated. We inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9498a5f929c5321dc16f3a69c09c524
https://doi.org/10.1091/mbc.e05-06-0532

Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study

Autor: Denis R. Morel, Pierre Croisille, Jean-Noël Hyacinthe, Sophie Richter, Diomidis Botsikas, Karin Montet-Abou, Jean-Pascal Jacob, Matthieu Lepetit-Coiffé, Jean-Luc Daire, Jean-Paul Vallée

Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 10, Iss 1, p 48 (2008)
Journal of Cardiovascular Magnetic Resonance, Vol. 10, No 1 (2008) P. 48
Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, BioMed Central, 2008, 10 (1), pp.48

Background The purpose of this study was to measure regional contractile function in the normal rat using cardiac cine and tagged cardiovascular magnetic resonance (CMR) during incremental low doses of dobutamine and at rest. Methods Five rats were i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0290bdcad928c3b50617a5cc87513b
http://www.jcmr-online.com/content/10/1/48

How prostacyclin improves cardiac output in right heart failure in conjunction with pulmonary hypertension

Autor: Benoît Rondelet, Ives Hubloue, Céline Dewachter, Serge Brimioulle, Francçois Kerbaul, Robert Naeije

RATIONALE: Prostacyclin therapy improves patients with pulmonary arterial hypertension, but whether this is attributable to an improved inotropic state of the right ventricle in addition to a decreased pulmonary arterial pulmonary vascular resistance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2302c4c845739d3e7c868d020a1f4bab
https://doi.org/10.1164/rccm.200611-1615oc